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Q4QP08

- NAGK_HAEI8

UniProt

Q4QP08 - NAGK_HAEI8

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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Haemophilus influenzae (strain 86-028NP)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi178 – 1781ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1408ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHINF281310:GJ89-258-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:NTHI0273
OrganismiHaemophilus influenzae (strain 86-028NP)
Taxonomic identifieri281310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000002525: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304N-acetyl-D-glucosamine kinasePRO_0000270106Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281310.NTHI0273.

Structurei

3D structure databases

ProteinModelPortaliQ4QP08.
SMRiQ4QP08. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiRTAKVPP.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QP08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYYGLDIGGT KIELAVFNEE LEKLYSERVP TPKTDYEEWL NTIVDLVNRA
60 70 80 90 100
DEKFGEVGTV GLGVPGFVNQ QTGLAEITNI RVADNKPILR DLSVRLGREV
110 120 130 140 150
RAENDANCFA LSEAWDTENQ QYPTVLGLIL GTGFGGGFVL NGKVHSGQVG
160 170 180 190 200
MAGELGHLQL NYHALKLLGW DNAPIYQCGC GNKACLDNYL SGRGFEMLYR
210 220 230 240 250
DLKGETLSAR EIIDLFYQGN ESAVDFVNLF VELAAISIGN IITAFDPHMI
260 270 280 290 300
VLGGGLSNFD YLYEALPKAL PPHLMRTAKV PPIKKAKHGD SGGVRGAAAL

FLTK
Length:304
Mass (Da):33,172
Last modified:July 19, 2005 - v1
Checksum:iD77ABD8CEF6BF5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000057 Genomic DNA. Translation: AAX87239.1.
RefSeqiYP_247899.1. NC_007146.2.

Genome annotation databases

EnsemblBacteriaiAAX87239; AAX87239; NTHI0273.
GeneIDi3429606.
KEGGihit:NTHI0273.
PATRICi20180723. VBIHaeInf100748_0249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000057 Genomic DNA. Translation: AAX87239.1 .
RefSeqi YP_247899.1. NC_007146.2.

3D structure databases

ProteinModelPortali Q4QP08.
SMRi Q4QP08. Positions 1-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281310.NTHI0273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX87239 ; AAX87239 ; NTHI0273 .
GeneIDi 3429606.
KEGGi hit:NTHI0273.
PATRICi 20180723. VBIHaeInf100748_0249.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
KOi K00884.
OMAi RTAKVPP.
OrthoDBi EOG61P6P0.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci HINF281310:GJ89-258-MONOMER.

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
    Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
    J. Bacteriol. 187:4627-4636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 86-028NP.

Entry informationi

Entry nameiNAGK_HAEI8
AccessioniPrimary (citable) accession number: Q4QP08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 19, 2005
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3