Reviewed, UniProtKB/Swiss-Prot Q4QP08 (NAGK_HAEI8)

Names and origin

Protein names

Recommended name:
    N-acetyl-D-glucosamine kinase
    EC=2.7.1.59
Alternative name(s):
    GlcNAc kinase

Gene names

Name:	nagK
Ordered Locus Names:	NTHI0273

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity.
Catalytic activity	ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. HAMAP MF_01271
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_01271
Sequence similarities	Belongs to the ROK (nagC/xylR) family. NagK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylglucosamine metabolic process Inferred from electronic annotation. Source: HAMAP peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP N-acetylglucosamine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	N-acetyl-D-glucosamine kinase HAMAP MF_01271		PRO_0000270106
Regions
	Nucleotide binding	4 – 11	8	ATP Potential
	Nucleotide binding	133 – 140	8	ATP Potential
Sites
	Metal binding	157	1	Zinc By similarity
	Metal binding	178	1	Zinc By similarity
	Metal binding	180	1	Zinc By similarity
	Metal binding	185	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QP08-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: D77ABD8CEF6BF5F9	FASTA	304	33,172
	10 20 30 40 50 60 MYYGLDIGGT KIELAVFNEE LEKLYSERVP TPKTDYEEWL NTIVDLVNRA DEKFGEVGTV 70 80 90 100 110 120 GLGVPGFVNQ QTGLAEITNI RVADNKPILR DLSVRLGREV RAENDANCFA LSEAWDTENQ 130 140 150 160 170 180 QYPTVLGLIL GTGFGGGFVL NGKVHSGQVG MAGELGHLQL NYHALKLLGW DNAPIYQCGC 190 200 210 220 230 240 GNKACLDNYL SGRGFEMLYR DLKGETLSAR EIIDLFYQGN ESAVDFVNLF VELAAISIGN 250 260 270 280 290 300 IITAFDPHMI VLGGGLSNFD YLYEALPKAL PPHLMRTAKV PPIKKAKHGD SGGVRGAAAL FLTK

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000057 Genomic DNA. Translation: AAX87239.1.
RefSeq	YP_247899.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3429606.
GenomeReviews	Gene locus NTHI0273 in contig CP000057_GR.
KEGG	hit:NTHI0273.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4QP08.
OMA	Q4QP08. HVERFME.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0273-MON.
Family and domain databases
HAMAP	MF_01271. [Tree]
InterPro	IPR000600. ROK. [Graphical view]
Pfam	PF00480. ROK. 1 hit. [Graphical view]
PROSITE	PS01125. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGK_HAEI8

Accession

Primary (citable) accession number: Q4QP08

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)