Reviewed, UniProtKB/Swiss-Prot Q4QNZ0 (SELD_HAEI8)

Names and origin

Protein names

Recommended name:
    Selenide, water dikinase
    EC=2.7.9.3
Alternative name(s):
    Selenophosphate synthetase
    Selenium donor protein

Gene names

Name:	selD
Ordered Locus Names:	NTHI0297

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Synthesizes selenophosphate from selenide and ATP By similarity.
Catalytic activity	ATP + selenide + H2O = AMP + selenophosphate + phosphate. HAMAP MF_00625
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the selenophosphate synthetase 1 family. Class I subfamily.
Sequence caution	The sequence AAX87257.1 differs from that shown. Reason: Erroneous termination at position 17. Translated as Sec.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	ATP-binding Magnesium Nucleotide-binding Selenium
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP selenide, water dikinase activity Inferred from electronic annotation. Source: HAMAP selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Selenide, water dikinase HAMAP MF_00625		PRO_0000318673
Regions
	Nucleotide binding	230 – 236	7	ATP Potential
Sites
	Active site	17	1	Potential
	Site	20	1	Important for catalytic activity By similarity
Amino acid modifications
	Non-standard residue	17	1	Selenocysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4QNZ0-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: A9A8338049442457	FASTA	347	36,454
	10 20 30 40 50 60 MAEEPIRLTQ YSHGAGUGCK ISPKVLGTIL HSELEKFYDP NLLVGNETAD DAAVYDLGNG 70 80 90 100 110 120 TAIISTTDFF MPIVDDPFDF GRIAATNAIS DIFAMGGKPI MGIAILGFPT NVLPAEVAQK 130 140 150 160 170 180 IVDGGRFACH QAGIALAGGH SIDSPEPIFG LAVTGVIDTE KVKRNASAKS GCKLYMTKPL 190 200 210 220 230 240 GIGILTTAEK KGKLKPEHQG LATAAMCQMN SIGSQFSQVD GVTAMTDVTG FGLLGHLIEI 250 260 270 280 290 300 CEGSNLSAVV FSDKIKTLDG VKDYIAQGCV PGGTGRNFES YGHKVGALTE EQKAILCDPQ 310 320 330 340 TSGGLLVAVE PNSVQTIIEI AKDTGIDLYE VGKLKPKSES DIVVEVK

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000057 Genomic DNA. Translation: AAX87257.1. Sequence problems.
RefSeq	YP_247917.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4QNZ0.
Genome annotation databases
GeneID	3429625.
GenomeReviews	Gene locus NTHI0297 in contig CP000057_GR.
KEGG	hit:NTHI0297.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4QNZ0.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0297-MON.
Family and domain databases
HAMAP	MF_00625. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004536. SelD. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF036407. Selenphspht_syn. 1 hit.
TIGRFAMs	TIGR00476. selD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SELD_HAEI8

Accession

Primary (citable) accession number: Q4QNZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	September 1, 2009
This is version 22 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)