ID   THIM_HAEI8              Reviewed;         265 AA.
AC   Q4QNC8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Hydroxyethylthiazole kinase;
DE            EC=2.7.1.50;
DE   AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase;
DE            Short=Thz kinase;
DE            Short=TH kinase;
GN   Name=thiM; OrderedLocusNames=NTHI0540;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + 4-methyl-5-(2-hydroxyethyl)thiazole =
CC       ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine pyrophosphate
CC       biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 4-methyl-
CC       5-(2-hydroxyethyl)-thiazole: step 1/1.
CC   -!- SIMILARITY: Belongs to the Thz kinase family.
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DR   EMBL; CP000057; AAX87469.1; -; Genomic_DNA.
DR   RefSeq; YP_248129.1; -.
DR   GeneID; 3429854; -.
DR   GenomeReviews; CP000057_GR; NTHI0540.
DR   KEGG; hit:NTHI0540; -.
DR   HOGENOM; Q4QNC8; -.
DR   OMA; Q4QNC8; ASPVMAH.
DR   BioCyc; HINF281310:NTHI0540-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004417; F:hydroxyethylthiazole kinase activity; IEA:HAMAP.
DR   GO; GO:0009228; P:thiamin biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00228; -; 1.
DR   InterPro; IPR000417; Hyethyz_kinase.
DR   InterPro; IPR011144; Hyethyz_kinsmonf.
DR   PANTHER; PTHR20857:SF14; Hyethyz_kinase; 1.
DR   Pfam; PF02110; HK; 1.
DR   PIRSF; PIRSF000513; Thz_kinase; 1.
DR   PRINTS; PR01099; HYETHTZKNASE.
DR   TIGRFAMs; TIGR00694; thiM; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Thiamine biosynthesis; Transferase.
FT   CHAIN         1    265       Hydroxyethylthiazole kinase.
FT                                /FTId=PRO_1000021513.
FT   BINDING      43     43       Substrate; via amide nitrogen (By
FT                                similarity).
FT   BINDING     119    119       ATP (By similarity).
FT   BINDING     165    165       ATP (By similarity).
FT   BINDING     192    192       Substrate; via amide nitrogen (By
FT                                similarity).
SQ   SEQUENCE   265 AA;  27774 MW;  4151D777FCBFCBD4 CRC64;
     MLMQSIYLSK IREQNPLIHN ITNIVAANFS ANGLLALGAS PLMSANIEEM QEVPKISQVL
     VINIGTLIGK DREAMLQAGK TANEVGIPVV LDPVGVGATS YRRETIRQLL AEVKFALIRG
     NAGELAAIAG ETWQAKGVDA GQGEVDLKAV AEKVAQRYGC TVLISGAVDI VSDGTQTATV
     HNGTSLFPKV TASGCLLSAV CAAFLAVSEG NYFSATLEAC VAYTIAGECA AQGLTTQVGQ
     FQIRLLDELA ALSPETIGQR GRINE
//