ID   NUDC_HAEI8              Reviewed;         264 AA.
AC   Q4QNB3;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=NADH pyrophosphatase;
DE            EC=3.6.1.22;
GN   Name=nudC; OrderedLocusNames=NTHI0557;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = AMP + NMN.
CC   -!- COFACTOR: Divalent ions. Manganese or magnesium (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. NudC subfamily.
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DR   EMBL; CP000057; AAX87484.1; -; Genomic_DNA.
DR   RefSeq; YP_248144.1; -.
DR   GeneID; 3429870; -.
DR   GenomeReviews; CP000057_GR; NTHI0557.
DR   KEGG; hit:NTHI0557; -.
DR   HOGENOM; Q4QNB3; -.
DR   OMA; Q4QNB3; SPCIIVA.
DR   BioCyc; HINF281310:NTHI0557-MON; -.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR   GO; GO:0000210; F:NAD+ diphosphatase activity; IEA:HAMAP.
DR   HAMAP; MF_00297; -; 1.
DR   InterPro; IPR015375; NADH_PPase-like_N.
DR   InterPro; IPR000086; NUDIX_hydrolase_core.
DR   InterPro; IPR015376; Znr_NADH_PPase.
DR   Gene3D; G3DSA:3.90.79.10; NUDIX_hydrolase; 1.
DR   Pfam; PF00293; NUDIX; 1.
DR   Pfam; PF09296; NUDIX-like; 1.
DR   Pfam; PF09297; zf-NADH-PPase; 1.
DR   ProDom; PD004109; IPP_isomerase; 1.
DR   PROSITE; PS00893; NUDIX; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Magnesium; Manganese; NAD.
FT   CHAIN         1    264       NADH pyrophosphatase.
FT                                /FTId=PRO_0000232116.
FT   MOTIF       163    184       Nudix box.
SQ   SEQUENCE   264 AA;  30206 MW;  F3807E750450B7CB CRC64;
     MKILQQDDFG YWLLTQGSNL YLVNNELPFG IAKDIDLEGL QAMQIGEWKN HPLWLVAEQE
     SDEREYVSLR NLLSLPEDEF HILSRGVEIN HFLKTHKFCG KCGHKTQQTQ DELAVQCIHC
     GYQTYPVICP SIIVAVRRGH EILLANHKRH YSPNGGIYTT LAGFVEVGET FEQAVQREVF
     EETGISIKNL RYFGSQPWAF PNSQMVGFLA DYESGEITLQ ESEIHDAQWF SYDQPLPELP
     PTGTIARKLI HVTLELCKAE HKCD
//