Q4QNB3 (NUDC_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH pyrophosphatase
EC=3.6.1.22

Gene names

Name:	nudC
Ordered Locus Names:	NTHI0557

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	NAD+ + H2O = AMP + NMN. HAMAP MF_00297
Cofactor	Divalent metal cations. Magnesium or manganese By similarity. Binds 1 zinc ion per subunit By similarity. HAMAP MF_00297
Subunit structure	Homodimer By similarity. HAMAP MF_00297
Sequence similarities	Belongs to the Nudix hydrolase family. NudC subfamily. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding NAD Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	NAD+ diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	NADH pyrophosphatase HAMAP MF_00297		PRO_0000232116
Regions
	Domain	126 – 253	128	Nudix hydrolase
	Motif	163 – 184	22	Nudix box HAMAP MF_00297
Sites
	Metal binding	99	1	Zinc By similarity
	Metal binding	102	1	Zinc By similarity
	Metal binding	117	1	Zinc By similarity
	Metal binding	120	1	Zinc By similarity
	Metal binding	178	1	Divalent metal cation By similarity
	Metal binding	182	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QNB3 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: F3807E750450B7CB	FASTA	264	30,206
	10 20 30 40 50 60 MKILQQDDFG YWLLTQGSNL YLVNNELPFG IAKDIDLEGL QAMQIGEWKN HPLWLVAEQE 70 80 90 100 110 120 SDEREYVSLR NLLSLPEDEF HILSRGVEIN HFLKTHKFCG KCGHKTQQTQ DELAVQCIHC 130 140 150 160 170 180 GYQTYPVICP SIIVAVRRGH EILLANHKRH YSPNGGIYTT LAGFVEVGET FEQAVQREVF 190 200 210 220 230 240 EETGISIKNL RYFGSQPWAF PNSQMVGFLA DYESGEITLQ ESEIHDAQWF SYDQPLPELP 250 260 PTGTIARKLI HVTLELCKAE HKCD

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 86-028NP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000057 Genomic DNA. Translation: AAX87484.1.
RefSeq	YP_248144.1. NC_007146.2.
3D structure databases
ProteinModelPortal	Q4QNB3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4QNB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3429870.
GenomeReviews	Gene locus NTHI0557 in contig CP000057_GR.
KEGG	hit:NTHI0557.
PATRIC	20181275. VBIHaeInf100748_0512.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2816.
HOGENOM	HBG736436.
OMA	PHSLMMG.
PhylomeDB	Q4QNB3.
ProtClustDB	PRK00241.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0557-MONOMER.
Family and domain databases
HAMAP	MF_00297. Nudix_NudC. [Tree]
InterPro	IPR015375. NADH_PPase-like_N. IPR022925. NADH_pyroPase_NudC. IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. IPR015376. Znr_NADH_PPase. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
KO	K03426.
Pfam	PF00293. NUDIX. 1 hit. PF09296. NUDIX-like. 1 hit. PF09297. zf-NADH-PPase. 1 hit. [Graphical view]
SUPFAM	SSF55811. NUDIX_hydrolase. 2 hits.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUDC_HAEI8

Accession

Primary (citable) accession number: Q4QNB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program