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Q4QN74

- HISX_HAEI8

UniProt

Q4QN74 - HISX_HAEI8

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Protein
Histidinol dehydrogenase
Gene
hisD, NTHI0600
Organism
Haemophilus influenzae (strain 86-028NP)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei185 – 1851NAD By similarity
Binding sitei208 – 2081NAD By similarity
Binding sitei232 – 2321Substrate By similarity
Metal bindingi254 – 2541Zinc By similarity
Binding sitei254 – 2541Substrate By similarity
Metal bindingi257 – 2571Zinc By similarity
Binding sitei257 – 2571Substrate By similarity
Active sitei321 – 3211Proton acceptor By similarity
Active sitei322 – 3221Proton acceptor By similarity
Binding sitei322 – 3221Substrate By similarity
Metal bindingi355 – 3551Zinc By similarity
Binding sitei355 – 3551Substrate By similarity
Binding sitei409 – 4091Substrate By similarity
Metal bindingi414 – 4141Zinc By similarity
Binding sitei414 – 4141Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciHINF281310:GJ89-562-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:NTHI0600
OrganismiHaemophilus influenzae (strain 86-028NP)
Taxonomic identifieri281310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000002525: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Histidinol dehydrogenaseUniRule annotation
PRO_0000135778Add
BLAST

Proteomic databases

PRIDEiQ4QN74.

Interactioni

Protein-protein interaction databases

STRINGi281310.NTHI0600.

Structurei

3D structure databases

ProteinModelPortaliQ4QN74.
SMRiQ4QN74. Positions 4-425.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QN74-1 [UniParc]FASTAAdd to Basket

« Hide

MQTIIWNHLS ETEKRKVIMR PVQQNGENIQ QAVNAIRENV AYNGDRALFE    50
LCEKFDGVKL DKLIVSADEI QAASSRISVK LRNAIEQAKT NIEAFHKAQQ 100
NQEIDLEIQE GVRCQVVTRP ISCVGLYIPG GSAPLFSTVL MLAIPAKIAG 150
CKKIVLCSPP PISDEILYTA HLCGVETIYA IGGAQAVFAM AQGTESVAKV 200
DKIFGPGNAF VTEAKRQVAQ NSTAIDMPAG PSEVLVIADE SADPEFVASD 250
LLSQAEHGAD SQVILVATCE TLAKETALAI ERQLALLPRA ETARKALNHS 300
RIFIAESLEQ AVEISNEYAP EHLIVQTKNA RKLLPYLDNA GSIFLGAYSP 350
ESMGDYASGT NHVLPTYGYT KTYSSLGLAD FSKRMTVQEL TPKGFKNLAE 400
TVEVMAEAEQ LAAHKMAVSV RLAKLNI 427
Length:427
Mass (Da):46,312
Last modified:July 19, 2005 - v1
Checksum:iB30E2B902B4C659B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000057 Genomic DNA. Translation: AAX87523.1.
RefSeqiWP_011272076.1. NC_007146.2.
YP_248183.1. NC_007146.2.

Genome annotation databases

EnsemblBacteriaiAAX87523; AAX87523; NTHI0600.
GeneIDi3429910.
KEGGihit:NTHI0600.
PATRICi20181357. VBIHaeInf100748_0552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000057 Genomic DNA. Translation: AAX87523.1 .
RefSeqi WP_011272076.1. NC_007146.2.
YP_248183.1. NC_007146.2.

3D structure databases

ProteinModelPortali Q4QN74.
SMRi Q4QN74. Positions 4-425.
ModBasei Search...

Protein-protein interaction databases

STRINGi 281310.NTHI0600.

Proteomic databases

PRIDEi Q4QN74.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX87523 ; AAX87523 ; NTHI0600 .
GeneIDi 3429910.
KEGGi hit:NTHI0600.
PATRICi 20181357. VBIHaeInf100748_0552.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci HINF281310:GJ89-562-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
    Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
    J. Bacteriol. 187:4627-4636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 86-028NP.

Entry informationi

Entry nameiHISX_HAEI8
AccessioniPrimary (citable) accession number: Q4QN74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 19, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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