Reviewed, UniProtKB/Swiss-Prot Q4QN73 (HIS81_HAEI8)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	NTHI0601

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153370
Amino acid modifications
	Modified residue	211	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QN73-1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: FFACC8DB2C4A15C9	FASTA	352	38,891
	10 20 30 40 50 60 MTITTLSRQN IQALTPYQSA RKLGGNGTIW LNANEYPTSP EFQLSGKDLN RYPEPQPQRV 70 80 90 100 110 120 VQAYANYAGV STENVLVTRG GDEGIELIIH TFCEPKQDAI LFCPPTYGMY AVSAETAGVL 130 140 150 160 170 180 SKSVPLTDDF QLNLPEIKNH LNDVKVVFVC SPNNPTGNLL KQSDILDLLQ ITAGKAIVVV 190 200 210 220 230 240 DEAYIEFCPE ASVINLLKNY PHLAIIRTLS KAFALAGLRC GFVLANPELI DILSKVIAPY 250 260 270 280 290 300 PIPVPSADLA EQALRPANIA TVQALTQELL SNRQWLAKAL LVLHQVEKVY ESEANYLLIK 310 320 330 340 350 CQNGQAVFKA LWEQGIILRD QNKTLHLQNC IRITVGTRNE CEKVVEAIKE VK

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000057 Genomic DNA. Translation: AAX87524.1. Different initiation.
RefSeq	YP_248184.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3429911.
GenomeReviews	Gene locus NTHI0601 in contig CP000057_GR.
KEGG	hit:NTHI0601.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4QN73.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0601-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_HAEI8

Accession

Primary (citable) accession number: Q4QN73

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	May 26, 2009
This is version 24 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)