ID   APAH_HAEI8              Reviewed;         275 AA.
AC   Q4QMZ7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical;
DE            EC=3.6.1.41;
DE   AltName: Full=Diadenosine tetraphosphatase;
DE   AltName: Full=Ap4A hydrolase;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase;
GN   Name=apaH; OrderedLocusNames=NTHI0679;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
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DR   EMBL; CP000057; AAX87600.1; -; Genomic_DNA.
DR   RefSeq; YP_248260.1; -.
DR   GeneID; 3429988; -.
DR   GenomeReviews; CP000057_GR; NTHI0679.
DR   KEGG; hit:NTHI0679; -.
DR   HOGENOM; Q4QMZ7; -.
DR   OMA; Q4QMZ7; LVFGHWA.
DR   BioCyc; HINF281310:NTHI0679-MON; -.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetr...; IEA:HAMAP.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    275       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_1000012061.
SQ   SEQUENCE   275 AA;  31792 MW;  6DF8192F040A60E6 CRC64;
     MATYFVGDLQ GCYDELQLLL ERVNFNPTQD KLYLVGDLVA RGDKSLECLR FVKSLGDSAQ
     TVLGNHDLHL IATALGIKKV KPRDRVDAIF NAPDFDELIH WLRHQPLLVH NKKLNFLMVH
     AGISPDWNLE TAKSCAAEVE QILQNGDFHY LIENMYSEQP DRWSPDLQGL ARHRYIINAF
     TRMRFCYLDH RLDFACKSPL KYAPTELTPW FNLGNPLYKQ IPIVFGHWAS LVDEPTPKGV
     YALDTGCVWN NRMTMLRWED KQIFTQSAVK NYSDF
//