Q4QMZ7 (APAH_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	NTHI0679

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012061

Sequences

	Sequence		Length	Mass (Da)
	Q4QMZ7 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 6DF8192F040A60E6	FASTA	275	31,792
	10 20 30 40 50 60 MATYFVGDLQ GCYDELQLLL ERVNFNPTQD KLYLVGDLVA RGDKSLECLR FVKSLGDSAQ 70 80 90 100 110 120 TVLGNHDLHL IATALGIKKV KPRDRVDAIF NAPDFDELIH WLRHQPLLVH NKKLNFLMVH 130 140 150 160 170 180 AGISPDWNLE TAKSCAAEVE QILQNGDFHY LIENMYSEQP DRWSPDLQGL ARHRYIINAF 190 200 210 220 230 240 TRMRFCYLDH RLDFACKSPL KYAPTELTPW FNLGNPLYKQ IPIVFGHWAS LVDEPTPKGV 250 260 270 YALDTGCVWN NRMTMLRWED KQIFTQSAVK NYSDF

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 86-028NP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000057 Genomic DNA. Translation: AAX87600.1.
RefSeq	YP_248260.1. NC_007146.2.
3D structure databases
ProteinModelPortal	Q4QMZ7.
SMR	Q4QMZ7. Positions 2-268.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4QMZ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3429988.
GenomeReviews	Gene locus NTHI0679 in contig CP000057_GR.
KEGG	hit:NTHI0679.
PATRIC	20181517. VBIHaeInf100748_0632.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HBG724457.
OMA	LVFGHWA.
PhylomeDB	Q4QMZ7.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0679-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_HAEI8

Accession

Primary (citable) accession number: Q4QMZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program