Reviewed, UniProtKB/Swiss-Prot Q4QMY0 (GPH_HAEI8)

Names and origin

Protein names

Recommended name:
    Phosphoglycolate phosphatase
      Short name=PGPase
      Short name=PGP
    EC=3.1.3.18

Gene names

Ordered Locus Names:

NTHI0697

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress By similarity.
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_00495
Pathway	Organic acid metabolism; glycolic acid biosynthesis; glycolic acid from 2-phosphoglycolic acid: step 1/1. HAMAP MF_00495
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. CbbY/cbbZ/gph/yieH family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Phosphoglycolate phosphatase HAMAP MF_00495		PRO_0000238159
Sites
	Active site	11	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QMY0-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: A5DA61CAAA66FFC9	FASTA	224	24,734
	10 20 30 40 50 60 MNTQFKLIGF DLDGTLVNSL PDLALSVNSA LAEFNLPKAP EELVLTWIGN GAPVLIARAL 70 80 90 100 110 120 DWAKKQTGKV LTETEVKQVT ERFNFYYGEN LCNVSRLYPN VKETLETLKE KGYVLAVVTN 130 140 150 160 170 180 KPTRHVQPVL AAFGIDHLFS EMLGGQSLPA IKPHPAPLYY LCGKFGFEPR QVLFVGDSKN 190 200 210 220 DIIAAHAAGC AVVGLTYGYN YNIPITESNP DWVFDDFAQL LTIL

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000057 Genomic DNA. Translation: AAX87617.1.
RefSeq	YP_248277.1.
3D structure databases
SMR	Q4QMY0. Positions 3-223.
ModBase	Search...
Genome annotation databases
GeneID	3430005.
GenomeReviews	Gene locus NTHI0697 in contig CP000057_GR.
KEGG	hit:NTHI0697.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4QMY0.
OMA	Q4QMY0. AVCEQFS.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0697-MON.
Family and domain databases
HAMAP	MF_00495. [Tree]
InterPro	IPR005834. Dehalogen-like_hydro. IPR006439. HAD-SF_hydro_IA_v1. IPR006402. HAD-SF_hydro_IA_v3. IPR005833. Haloacid_DH/epoxide_hydro. IPR006346. PGP_bact. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00413. HADHALOGNASE.
TIGRFAMs	TIGR01549. HAD-SF-IA-v1. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit. TIGR01449. PGP_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPH_HAEI8

Accession

Primary (citable) accession number: Q4QMY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)