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Q4QML4 (TNAA_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophanase
EC=4.1.99.1
Alternative name(s):
L-tryptophan indole-lyase
Short name=TNase
Gene names
Name:tnaA
Ordered Locus Names:NTHI0831
OrganismHaemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]
Taxonomic identifier281310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus ›

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-tryptophan + H2O = indole + pyruvate + NH3. HAMAP-Rule MF_00544

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00544

Pathway

Amino-acid degradation; L-tryptophan degradation via pyruvate pathway; indole and pyruvate from L-tryptophan: step 1/1. HAMAP-Rule MF_00544

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00544

Sequence similarities

Belongs to the beta-eliminating lyase family.

Ontologies

Keywords
   Biological processTryptophan catabolism
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

tryptophanase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Tryptophanase HAMAP-Rule MF_00544
PRO_1000017731

Amino acid modifications

Modified residue2701N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4QML4 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 93F922230E86BAEB

FASTA47253,105
        10         20         30         40         50         60 
MENFKHLPEP FRIRVIEPVK RTTREYREQA MLKSGMNPFL LDSEDIFIDL LTDSGTGAVT 

        70         80         90        100        110        120 
QDMQAAMLRG DEAYSGSRSY YALAKAVKDI FGYEYTIPTH QGRGAEQIYI PVLIAKRERE 

       130        140        150        160        170        180 
KGLDRSKMVV FSNYFFDTTQ GHSQINGATV RNVYIKEAFD TTAKHPFKGN FDLEKLEKGI 

       190        200        210        220        230        240 
QEAGAHNVPY IVCTITCNSA GGQPVSIANL KGMYEIARKY DIPVIMDSAR FAENAYFVQQ 

       250        260        270        280        290        300 
REEAYKDWTI EQITYESYRY ADGLAMSAKK DAMVPMGGIL AFKDKSMEEV YHECRTLCVV 

       310        320        330        340        350        360 
QEGFPTYGGL EGGAMERLAV GLHDGMRQEW LAYRIAQIEY LVAGLEKIGV PCQQPGGHAA 

       370        380        390        400        410        420 
FVDAGKLLPH IPADQFPAQA LSCELYKVAG IRAVEIGSFL LGRDPKTGKQ LPCPAELLRL 

       430        440        450        460        470 
TIPRATYTQT HMDFIIEAFQ KVKENAENIK GLTFTYEPKV LRHFTARLKE VE

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References

[1]"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
J. Bacteriol. 187:4627-4636(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 86-028NP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000057 Genomic DNA. Translation: AAX87733.1.
RefSeqYP_248393.1. NC_007146.2.

3D structure databases

ProteinModelPortalQ4QML4.
SMRQ4QML4. Positions 4-471.
ModBaseSearch...

Protein-protein interaction databases

STRING281310.NTHI0831.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX87733; AAX87733; NTHI0831.
GeneID3430136.
KEGGhit:NTHI0831.
PATRIC20181827. VBIHaeInf100748_0775.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3033.
HOGENOMHOG000057883.
KOK01667.
OMAGRGAENV.
ProtClustDBPRK13238.

Enzyme and pathway databases

BioCycHINF281310:GJ89-788-MONOMER.
UniPathwayUPA00332; UER00452.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_00544. Tryptophanase.
InterProIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR011166. Beta-eliminating_lyase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR013440. TNase.
IPR018176. Tryptophanase_CS.
[Graphical view]
PfamPF01212. Beta_elim_lyase. 1 hit.
[Graphical view]
PIRSFPIRSF001386. Trpase. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR02617. tnaA_trp_ase. 1 hit.
PROSITEPS00853. BETA_ELIM_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTNAA_HAEI8
AccessionPrimary (citable) accession number: Q4QML4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 30, 2005
Last modified: May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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