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Q4QLU8

- NAGZ_HAEI8

UniProt

Q4QLU8 - NAGZ_HAEI8

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Protein
Beta-hexosaminidase
Gene
nagZ, NTHI1132
Organism
Haemophilus influenzae (strain 86-028NP)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Substrate By similarity
Binding sitei70 – 701Substrate By similarity
Binding sitei133 – 1331Substrate By similarity
Sitei174 – 1741Important for catalytic activity By similarity
Active sitei176 – 1761Proton donor/acceptor By similarity
Active sitei248 – 2481Nucleophile By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-KW
  5. peptidoglycan turnover Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciHINF281310:GJ89-1076-MONOMER.
UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nagZ
Ordered Locus Names:NTHI1132
OrganismiHaemophilus influenzae (strain 86-028NP)
Taxonomic identifieri281310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000002525: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Beta-hexosaminidaseUniRule annotation
PRO_0000234913Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281310.NTHI1132.

Structurei

3D structure databases

ProteinModelPortaliQ4QLU8.
SMRiQ4QLU8. Positions 1-298.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1642Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
KOiK01207.
OMAiYTEADPR.
OrthoDBiEOG6BCT06.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QLU8-1 [UniParc]FASTAAdd to Basket

« Hide

MSTLLIDLKG KELEQEEVEL LSHPLVAGLI LFTRNFEDRE QIQELIRSVR    50
QRVKKPLLIT VDQEGGRVQR FRDGFTMLPS MQAFQETLSA TEQVSFAKEA 100
GWQMAAEMIA LDIDLSFAPV LDLGHECRAI GDRSFSSDVK SAVNLAINFI 150
DGMHQAGMAS TGKHFPGHGH VLADSHLETP YDDRAKDEIF GYDLQPFQQL 200
ISQNKLDAIM PAHVIYGQCD SQPASGSEYW LKEILRKKLN FQGTIFSDDL 250
GMKGAGVMGN FVERSKKALN AGCDLLLLCN EREGVIQVLD NLKLTENEPH 300
FMARQARLKN LFKRSVIEWN DLVLDQRWKL NHRNLADIQS RWLDIQAAKN 350
D 351
Length:351
Mass (Da):39,723
Last modified:July 19, 2005 - v1
Checksum:i5562982C0542E672
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000057 Genomic DNA. Translation: AAX87999.1.
RefSeqiWP_011272310.1. NC_007146.2.
YP_248659.1. NC_007146.2.

Genome annotation databases

EnsemblBacteriaiAAX87999; AAX87999; NTHI1132.
GeneIDi3430424.
KEGGihit:NTHI1132.
PATRICi20182421. VBIHaeInf100748_1054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000057 Genomic DNA. Translation: AAX87999.1 .
RefSeqi WP_011272310.1. NC_007146.2.
YP_248659.1. NC_007146.2.

3D structure databases

ProteinModelPortali Q4QLU8.
SMRi Q4QLU8. Positions 1-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281310.NTHI1132.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX87999 ; AAX87999 ; NTHI1132 .
GeneIDi 3430424.
KEGGi hit:NTHI1132.
PATRICi 20182421. VBIHaeInf100748_1054.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000248526.
KOi K01207.
OMAi YTEADPR.
OrthoDBi EOG6BCT06.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci HINF281310:GJ89-1076-MONOMER.

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
    Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
    J. Bacteriol. 187:4627-4636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 86-028NP.

Entry informationi

Entry nameiNAGZ_HAEI8
AccessioniPrimary (citable) accession number: Q4QLU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 19, 2005
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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