Q4QLU8 (NAGZ_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-hexosaminidase
EC=3.2.1.52

Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	NTHI1132

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity. HAMAP MF_00364
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_00364
Subcellular location	Cytoplasm By similarity HAMAP MF_00364.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Beta-hexosaminidase HAMAP MF_00364		PRO_0000234913
Sites
	Active site	248	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QLU8 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 5562982C0542E672	FASTA	351	39,723
	10 20 30 40 50 60 MSTLLIDLKG KELEQEEVEL LSHPLVAGLI LFTRNFEDRE QIQELIRSVR QRVKKPLLIT 70 80 90 100 110 120 VDQEGGRVQR FRDGFTMLPS MQAFQETLSA TEQVSFAKEA GWQMAAEMIA LDIDLSFAPV 130 140 150 160 170 180 LDLGHECRAI GDRSFSSDVK SAVNLAINFI DGMHQAGMAS TGKHFPGHGH VLADSHLETP 190 200 210 220 230 240 YDDRAKDEIF GYDLQPFQQL ISQNKLDAIM PAHVIYGQCD SQPASGSEYW LKEILRKKLN 250 260 270 280 290 300 FQGTIFSDDL GMKGAGVMGN FVERSKKALN AGCDLLLLCN EREGVIQVLD NLKLTENEPH 310 320 330 340 350 FMARQARLKN LFKRSVIEWN DLVLDQRWKL NHRNLADIQS RWLDIQAAKN D

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 86-028NP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000057 Genomic DNA. Translation: AAX87999.1.
RefSeq	YP_248659.1. NC_007146.2.
3D structure databases
ProteinModelPortal	Q4QLU8.
SMR	Q4QLU8. Positions 1-298.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4QLU8.
Protein family/group databases
CAZy	GH3. Glycoside Hydrolase Family 3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3430424.
GenomeReviews	Gene locus NTHI1132 in contig CP000057_GR.
KEGG	hit:NTHI1132.
PATRIC	20182421. VBIHaeInf100748_1054.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1472.
HOGENOM	HBG617255.
OMA	EHPLVGG.
PhylomeDB	Q4QLU8.
ProtClustDB	PRK05337.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI1132-MONOMER.
Family and domain databases
HAMAP	MF_00364. NagZ. [Tree]
InterPro	IPR022956. Beta_hexosaminidase. IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.300. Glyco_hydro_3_N. 1 hit.
KO	K01207.
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_HAEI8

Accession

Primary (citable) accession number: Q4QLU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program