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Q4QLL8 (NRFA_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c-552
EC=1.7.2.2
Alternative name(s):
Ammonia-forming cytochrome c nitrite reductase
Short name=Cytochrome c nitrite reductase
Gene names
Name:nrfA
Ordered Locus Names:NTHI1230
OrganismHaemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]
Taxonomic identifier281310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in nitrite reduction By similarity. HAMAP MF_01182

Catalytic activity

NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+. HAMAP MF_01182

Cofactor

Binds 1 calcium ion per monomer By similarity. HAMAP MF_01182

Binds 5 heme groups covalently per monomer By similarity.

Pathway

Nitrogen metabolism; nitrate reduction (assimilation). HAMAP MF_01182

Subcellular location

Periplasm By similarity HAMAP MF_01182.

Sequence similarities

Belongs to the cytochrome c-552 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5555 Potential
Chain56 – 538483Cytochrome c-552 HAMAP MF_01182
PRO_0000268967

Sites

Metal binding1331Iron (heme 3 axial ligand) By similarity
Metal binding1651Iron (heme 1 axial ligand) By similarity
Metal binding2031Iron (heme 2 axial ligand) By similarity
Metal binding2681Iron (heme 3 axial ligand) By similarity
Metal binding2701Calcium By similarity
Metal binding2711Calcium; via carbonyl oxygen By similarity
Metal binding3161Calcium; via carbonyl oxygen By similarity
Metal binding3181Calcium By similarity
Metal binding3301Iron (heme 5 axial ligand) By similarity
Metal binding3411Iron (heme 4 axial ligand) By similarity
Metal binding3561Iron (heme 2 axial ligand) By similarity
Metal binding3731Iron (heme 5 axial ligand) By similarity
Metal binding4481Iron (heme 4 axial ligand) By similarity
Binding site1611Heme 1 (covalent) By similarity
Binding site1641Heme 1 (covalent) By similarity
Binding site1991Heme 2 (covalent) By similarity
Binding site2021Heme 2 (covalent) By similarity
Binding site2641Heme 3 (covalent) By similarity
Binding site2671Heme 3 (covalent) By similarity
Binding site2711Substrate By similarity
Binding site3191Substrate By similarity
Binding site3371Heme 4 (covalent) By similarity
Binding site3401Heme 4 (covalent) By similarity
Binding site3691Heme 5 (covalent) By similarity
Binding site3721Heme 5 (covalent) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4QLL8 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 6BB030F62F289E76

FASTA53860,367
        10         20         30         40         50         60 
MKIYLRFVWI LIIILNFLLN LFITTNGVII VNAFKKSLIV AASFASLSLF NSATAELVYK 

        70         80         90        100        110        120 
PLEQPVEPAK PDLKIESVNE KFAEKYPNQY NSWRSTANGD GENIIYADEE NPRLIVLWGG 

       130        140        150        160        170        180 
YAFAKEYNAP RGHFYAVTDV RNILRTGAPK TANDGPQAMA CWTCKGPDVP RLIAEWGEKD 

       190        200        210        220        230        240 
YFNAKWAKGG PEIVNSIGCA DCHDTTSKDF AEGKPALRIA RPHVLRALDA LEKATAEKDK 

       250        260        270        280        290        300 
AEGRPHNNLS FNTAARTEKR AEICANCHVE YYFAGDIKQV TFPWDNGQTA DDIEKYYDDI 

       310        320        330        340        350        360 
GFTDWTHSLS KAPMLKAQHP DFEIWSLGMH GKNGVTCVDC HMPKVQGADG KVYTDHQIQN 

       370        380        390        400        410        420 
PFDAFDHTCA NCHDQSKEKL RDIVTSRKKE VKDVMGRLED QVVKSHFEAK AAWDAGATKE 

       430        440        450        460        470        480 
EMEAALMDIR HAQWRWDYTA ASHGGHMHAP EVVLRVLASG LDKVADARTK LAVILTKHGV 

       490        500        510        520        530 
KTPVQIPDIS TADKAWKVMG IDIEKERKAK EEFLKTVVPQ WEQQAREKGL LVDPPAQK

« Hide

References

[1]"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 86-028NP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000057 Genomic DNA. Translation: AAX88079.1.
RefSeqYP_248739.1. NC_007146.2.

3D structure databases

HSSPHSSP built from PDB template 1FS7 based on UniProtKB Q9S1E5.
ProteinModelPortalQ4QLL8.
SMRQ4QLL8. Positions 75-532.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4QLL8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3430505.
GenomeReviewsGene locus NTHI1230 in contig CP000057_GR.
KEGGhit:NTHI1230.
PATRIC20182589. VBIHaeInf100748_1138.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3303.
HOGENOMHBG488281.
OMAPFAKASK.
PhylomeDBQ4QLL8.
ProtClustDBPRK11125.

Enzyme and pathway databases

BioCycHINF281310:NTHI1230-MONOMER.

Family and domain databases

HAMAPMF_01182. Cytochrom_C552.
[Tree]
InterProIPR003321. Cyt_c552.
IPR017570. Cyt_c_NO2Rdtase_formate-dep.
IPR011031. Multihaem_cyt.
[Graphical view]
KOK03385.
PfamPF02335. Cytochrom_C552. 1 hit.
[Graphical view]
PIRSFPIRSF000243. Cyt_c552. 1 hit.
TIGRFAMsTIGR03152. Cyto_c552_HCOOH. 1 hit.
PROSITEPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNRFA_HAEI8
AccessionPrimary (citable) accession number: Q4QLL8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 19, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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