ID   XYLA_HAEI8              Reviewed;         439 AA.
AC   Q4QLI2;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Xylose isomerase;
DE            EC=5.3.1.5;
GN   Name=xylA; OrderedLocusNames=NTHI1276;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- CATALYTIC ACTIVITY: D-xylose = D-xylulose.
CC   -!- COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the xylose isomerase family.
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DR   EMBL; CP000057; AAX88115.1; -; Genomic_DNA.
DR   RefSeq; YP_248775.1; -.
DR   GeneID; 3430543; -.
DR   GenomeReviews; CP000057_GR; NTHI1276.
DR   KEGG; hit:NTHI1276; -.
DR   HOGENOM; Q4QLI2; -.
DR   OMA; Q4QLI2; QFLIEPK.
DR   BioCyc; HINF281310:NTHI1276-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009045; F:xylose isomerase activity; IEA:HAMAP.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:HAMAP.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR   HAMAP; MF_00455; -; 1.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   InterPro; IPR012307; Xyl_isomerase-typ_TIM-brl.
DR   InterPro; IPR013452; Xylose_isom_bac.
DR   InterPro; IPR001998; Xylose_isomerase.
DR   InterPro; IPR018115; Xylose_isomerase_AS.
DR   Gene3D; G3DSA:3.20.20.150; Xyl_isomerase-like_TIM-brl; 1.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PRINTS; PR00688; XYLOSISMRASE.
DR   TIGRFAMs; TIGR02630; xylose_isom_A; 1.
DR   PROSITE; PS51415; XYLOSE_ISOMERASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Cytoplasm; Isomerase;
KW   Magnesium; Metal-binding; Pentose shunt; Xylose metabolism.
FT   CHAIN         1    439       Xylose isomerase.
FT                                /FTId=PRO_0000236963.
FT   ACT_SITE    101    101       By similarity.
FT   ACT_SITE    104    104       By similarity.
FT   METAL       232    232       Magnesium 1 (By similarity).
FT   METAL       268    268       Magnesium 1 (By similarity).
FT   METAL       268    268       Magnesium 2 (By similarity).
FT   METAL       271    271       Magnesium 2 (By similarity).
FT   METAL       296    296       Magnesium 1 (By similarity).
FT   METAL       307    307       Magnesium 2 (By similarity).
FT   METAL       309    309       Magnesium 2 (By similarity).
FT   METAL       339    339       Magnesium 1 (By similarity).
SQ   SEQUENCE   439 AA;  49833 MW;  2E50D8A124E9A005 CRC64;
     MTTYFDKIEK ISFEGEKSTN PFAFKHYDAN QVILGKTMAE HLRLAVCYWH TFCWNGNDMF
     GLGSLERSWQ KNPNVLAGAE QKADIAFEFL NKLGVPYYCF HDVDIAPEGN SVREYVQNFH
     HIVDILERKQ VETGVKLLWG TANCFTNPRY MSGAATNPNP EVFAWAATQV FNAMNATQRL
     GGENYVLWGG REGYETLLNT DLKREREQIG RFMQMVVEHK HKIGFKGTLL IEPKPQEPTK
     HQYDYDVATV YGFLKQFGLE KEIKVNIEAN HATLAGHTFQ HEIATACALD IFGSIDANRG
     DPQLGWDTDQ FPNSVEENTL VMYEILKHGG FTTGGFNFDA KIRRQSIDPY DLFYAHIGAI
     DVLALSLKRA AKMLQEKTLQ KIVNARYAGW NSELGQHILQ GKTSLETLAQ LVQQKDLAPK
     PVSGQQEYLE NLVNQVIYS
//