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Reviewed, UniProtKB/Swiss-Prot Q4QLI2 (XYLA_HAEI8)

Last modified June 16, 2009. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Xylose isomerase
    EC=5.3.1.5
Gene names
Name: xylA
Ordered Locus Names: NTHI1276
OrganismHaemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]
Taxonomic identifier281310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the xylose isomerase family.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processD-xylose metabolic process

Inferred from electronic annotation. Source: HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmagnesium ion binding

Inferred from electronic annotation. Source: HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Xylose isomerase HAMAP MF_00455
PRO_0000236963

Sites

Active site1011 By similarity
Active site1041 By similarity
Metal binding2321Magnesium 1 By similarity
Metal binding2681Magnesium 1 By similarity
Metal binding2681Magnesium 2 By similarity
Metal binding2711Magnesium 2 By similarity
Metal binding2961Magnesium 1 By similarity
Metal binding3071Magnesium 2 By similarity
Metal binding3091Magnesium 2 By similarity
Metal binding3391Magnesium 1 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q4QLI2-1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 2E50D8A124E9A005

FASTA43949,833
        10         20         30         40         50         60 
MTTYFDKIEK ISFEGEKSTN PFAFKHYDAN QVILGKTMAE HLRLAVCYWH TFCWNGNDMF 

        70         80         90        100        110        120 
GLGSLERSWQ KNPNVLAGAE QKADIAFEFL NKLGVPYYCF HDVDIAPEGN SVREYVQNFH 

       130        140        150        160        170        180 
HIVDILERKQ VETGVKLLWG TANCFTNPRY MSGAATNPNP EVFAWAATQV FNAMNATQRL 

       190        200        210        220        230        240 
GGENYVLWGG REGYETLLNT DLKREREQIG RFMQMVVEHK HKIGFKGTLL IEPKPQEPTK 

       250        260        270        280        290        300 
HQYDYDVATV YGFLKQFGLE KEIKVNIEAN HATLAGHTFQ HEIATACALD IFGSIDANRG 

       310        320        330        340        350        360 
DPQLGWDTDQ FPNSVEENTL VMYEILKHGG FTTGGFNFDA KIRRQSIDPY DLFYAHIGAI 

       370        380        390        400        410        420 
DVLALSLKRA AKMLQEKTLQ KIVNARYAGW NSELGQHILQ GKTSLETLAQ LVQQKDLAPK 

       430 
PVSGQQEYLE NLVNQVIYS

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References

[1]"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000057 Genomic DNA. Translation: AAX88115.1.
RefSeqYP_248775.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3430543.
GenomeReviewsGene locus NTHI1276 in contig CP000057_GR.
KEGGhit:NTHI1276.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ4QLI2.
OMAQ4QLI2. QFLIEPK.

Enzyme and pathway databases

BioCycHINF281310:NTHI1276-MON.

Family and domain databases

HAMAPMF_00455.
[Tree]
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR012307. Xyl_isomerase-typ_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
IPR018115. Xylose_isomerase_AS.
[Graphical view]
Gene3DG3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameXYLA_HAEI8
AccessionPrimary (citable) accession number: Q4QLI2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 19, 2005
Last modified: June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents