ID   HLDD_HAEI8              Reviewed;         308 AA.
AC   Q4QLI0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
DE            EC=5.1.3.20;
DE   AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
DE            Short=ADP-glyceromanno-heptose 6-epimerase;
DE            Short=ADP-hep 6-epimerase;
DE            Short=AGME;
GN   Name=hldD; OrderedLocusNames=NTHI1278;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Catalyzes the interconversion between ADP-D-glycero-
CC       beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an
CC       epimerization at carbon 6 of the heptose (By similarity).
CC   -!- CATALYTIC ACTIVITY: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-
CC       D-manno-heptose.
CC   -!- COFACTOR: Binds 1 NADP(+) per subunit (By similarity).
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-
CC       manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose
CC       from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
CC   -!- SUBUNIT: Homopentamer (By similarity).
CC   -!- DOMAIN: Contains a large N-terminal NADP-binding domain, and a
CC       smaller C-terminal substrate-binding domain (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family. HldD subfamily.
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DR   EMBL; CP000057; AAX88117.1; -; Genomic_DNA.
DR   RefSeq; YP_248777.1; -.
DR   SMR; Q4QLI0; 1-306.
DR   GeneID; 3430545; -.
DR   GenomeReviews; CP000057_GR; NTHI1278.
DR   KEGG; hit:NTHI1278; -.
DR   HOGENOM; Q4QLI0; -.
DR   OMA; Q4QLI0; FGPNEYH.
DR   BioCyc; HINF281310:NTHI1278-MON; -.
DR   GO; GO:0008712; F:ADP-glyceromanno-heptose 6-epimerase activity; IEA:HAMAP.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:HAMAP.
DR   GO; GO:0044237; P:cellular metabolic process; IEA:InterPro.
DR   HAMAP; MF_01601; -; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR011912; Heptose_epim.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR10366:SF29; Heptose_epim; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   TIGRFAMs; TIGR02197; heptose_epim; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Isomerase; NADP.
FT   CHAIN         1    308       ADP-L-glycero-D-manno-heptose-6-
FT                                epimerase.
FT                                /FTId=PRO_0000255731.
FT   NP_BIND      10     11       NADP (By similarity).
FT   NP_BIND      31     32       NADP (By similarity).
FT   NP_BIND      75     79       NADP (By similarity).
FT   REGION      200    203       Substrate binding (By similarity).
FT   ACT_SITE    139    139       Proton acceptor (By similarity).
FT   ACT_SITE    177    177       Proton acceptor (By similarity).
FT   BINDING      38     38       NADP (By similarity).
FT   BINDING      53     53       NADP (By similarity).
FT   BINDING      92     92       NADP (By similarity).
FT   BINDING     143    143       NADP (By similarity).
FT   BINDING     168    168       Substrate (By similarity).
FT   BINDING     169    169       NADP; via amide nitrogen (By similarity).
FT   BINDING     177    177       NADP (By similarity).
FT   BINDING     179    179       Substrate; via carbonyl oxygen (By
FT                                similarity).
FT   BINDING     186    186       Substrate (By similarity).
FT   BINDING     208    208       Substrate (By similarity).
FT   BINDING     271    271       Substrate (By similarity).
SQ   SEQUENCE   308 AA;  34701 MW;  47905759037F6C55 CRC64;
     MIIVTGGAGF IGSNIVKALN DLGRKDILVV DNLKDGTKFA NLVDLDIADY CDKEDFIASI
     IAGDEFGDID AVFHEGACSA TTEWDGKYIM HNNYEYSKEL LHYCLDREIP FFYASSAATY
     GDTKVFREER EFEGPLNVYG YSKFLFDQYV RNILPEAKSP VCGFRYFNVY GPRENHKGSM
     ASVAFHLNNQ ILKGENPKLF AGSEGFRRDF VYVGDVAAVN IWCWQNGISG IYNLGTGNAE
     SFRAVADAVV KFHGKGEIET IPFPEHLKSR YQEYTQADLT KLRSTGYDKP FKTVAEGVTE
     YMAWLNRK
//