UniProtKB - Q4QL07 (G6PI_HAEI8)
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Protein
Glucose-6-phosphate isomerase
Gene
pgi
Organism
Haemophilus influenzae (strain 86-028NP)
Status
Functioni
Catalytic activityi
D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation
: glycolysis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Glucose-6-phosphate isomerase (pgi)
- ATP-dependent 6-phosphofructokinase (pfkA)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 355 | Proton donorUniRule annotation | 1 | |
Active sitei | 387 | UniRule annotation | 1 | |
Active sitei | 515 | UniRule annotation | 1 |
GO - Molecular functioni
- glucose-6-phosphate isomerase activity Source: UniProtKB-EC
GO - Biological processi
- gluconeogenesis Source: UniProtKB-KW
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Biological process | Gluconeogenesis, Glycolysis |
Enzyme and pathway databases
UniPathwayi | UPA00109; UER00181 |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation |
Gene namesi | Name:pgiUniRule annotation Ordered Locus Names:NTHI1475 |
Organismi | Haemophilus influenzae (strain 86-028NP) |
Taxonomic identifieri | 281310 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180651 | 1 – 549 | Glucose-6-phosphate isomeraseAdd BLAST | 549 |
Proteomic databases
PRIDEi | Q4QL07 |
Structurei
3D structure databases
ProteinModelPortali | Q4QL07 |
SMRi | Q4QL07 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the GPI family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000261370 |
KOi | K01810 |
OrthoDBi | POG091H04C3 |
Family and domain databases
CDDi | cd05015 SIS_PGI_1, 1 hit cd05016 SIS_PGI_2, 1 hit |
Gene3Di | 1.10.1390.101 hit |
HAMAPi | MF_00473 G6P_isomerase, 1 hit |
InterProi | View protein in InterPro IPR001672 G6P_Isomerase IPR023096 G6P_Isomerase_C IPR018189 Phosphoglucose_isomerase_CS IPR035476 SIS_PGI_1 IPR035482 SIS_PGI_2 |
PANTHERi | PTHR11469 PTHR11469, 1 hit |
Pfami | View protein in Pfam PF00342 PGI, 1 hit |
PRINTSi | PR00662 G6PISOMERASE |
PROSITEi | View protein in PROSITE PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4QL07-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNINPTHTQ AWKSLEAHKA ELSNTTIQDL FKQEKNRFDD YSLTFNNQIL
60 70 80 90 100
VDFSKNNINQ TTLSHLRQLA QECALDSAKE AMFTGEKINR TENRAVLHTA
110 120 130 140 150
LRNRTNTPVL VDGKDVMPEV NAVLAKMKDF CQRIISGEWK GYTGKAITDV
160 170 180 190 200
VNIGIGGSDL GPYMVTEALR PYKNHLNMHF VSNVDGTHIA ETLKKVNPET
210 220 230 240 250
TLFLVASKTF TTQETMTNAQ SARDWLLKAA KDESAVAKHF AALSTNAKDV
260 270 280 290 300
EKFGIDTNNM FEFWDWVGGR YSLWSAIGLS IALSIGFENF EALLNGAHEM
310 320 330 340 350
DKHFRTTPIE KNIPTTLALV GLWNTNFLGA QTEAILPYDQ YLHRFAAYFQ
360 370 380 390 400
QGNMESNGKY VDRDGNVINN YQTGPIIWGE PGTNGQHAFY QLIHQGTTLI
410 420 430 440 450
PCDFIAPAQS HNPLADHHNK LLSNFFAQTE ALAFGKTKEE VEAEFVKAGK
460 470 480 490 500
SLDDVKNIVP FKVFTGNKPT NSILVQKITP FTLGALIAMY EHKIFVQGVI
510 520 530 540
FNIFSFDQWG VELGKQLANR ILPELTDSEK VASHDSSTNG LINQFKAWR
Sequence cautioni
The sequence AAX88290 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000057 Genomic DNA Translation: AAX88290.1 Different initiation. |
RefSeqi | WP_011272485.1, NC_007146.2 |
Genome annotation databases
EnsemblBacteriai | AAX88290; AAX88290; NTHI1475 |
KEGGi | hit:NTHI1475 |
Similar proteinsi
Entry informationi
Entry namei | G6PI_HAEI8 | |
Accessioni | Q4QL07Primary (citable) accession number: Q4QL07 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | February 28, 2018 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |