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Q4QL07 (G6PI_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:NTHI1475
OrganismHaemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]
Taxonomic identifier281310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence AAX88290.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180651

Sites

Active site3551Proton donor By similarity
Active site3871 By similarity
Active site5151 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4QL07 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: B57659BE25B9706F

FASTA54961,561
        10         20         30         40         50         60 
MKNINPTHTQ AWKSLEAHKA ELSNTTIQDL FKQEKNRFDD YSLTFNNQIL VDFSKNNINQ 

        70         80         90        100        110        120 
TTLSHLRQLA QECALDSAKE AMFTGEKINR TENRAVLHTA LRNRTNTPVL VDGKDVMPEV 

       130        140        150        160        170        180 
NAVLAKMKDF CQRIISGEWK GYTGKAITDV VNIGIGGSDL GPYMVTEALR PYKNHLNMHF 

       190        200        210        220        230        240 
VSNVDGTHIA ETLKKVNPET TLFLVASKTF TTQETMTNAQ SARDWLLKAA KDESAVAKHF 

       250        260        270        280        290        300 
AALSTNAKDV EKFGIDTNNM FEFWDWVGGR YSLWSAIGLS IALSIGFENF EALLNGAHEM 

       310        320        330        340        350        360 
DKHFRTTPIE KNIPTTLALV GLWNTNFLGA QTEAILPYDQ YLHRFAAYFQ QGNMESNGKY 

       370        380        390        400        410        420 
VDRDGNVINN YQTGPIIWGE PGTNGQHAFY QLIHQGTTLI PCDFIAPAQS HNPLADHHNK 

       430        440        450        460        470        480 
LLSNFFAQTE ALAFGKTKEE VEAEFVKAGK SLDDVKNIVP FKVFTGNKPT NSILVQKITP 

       490        500        510        520        530        540 
FTLGALIAMY EHKIFVQGVI FNIFSFDQWG VELGKQLANR ILPELTDSEK VASHDSSTNG 


LINQFKAWR 

« Hide

References

[1]"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
J. Bacteriol. 187:4627-4636(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 86-028NP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000057 Genomic DNA. Translation: AAX88290.1. Different initiation.
RefSeqYP_248950.2. NC_007146.2.

3D structure databases

ProteinModelPortalQ4QL07.
SMRQ4QL07. Positions 10-549.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281310.NTHI1475.

Proteomic databases

PRIDEQ4QL07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX88290; AAX88290; NTHI1475.
GeneID3430724.
KEGGhit:NTHI1475.
PATRIC20183047. VBIHaeInf100748_1363.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycHINF281310:GJ89-1376-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_HAEI8
AccessionPrimary (citable) accession number: Q4QL07
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 11, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways