Q4QL07 (G6PI_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	NTHI1475

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00473.
Sequence similarities	Belongs to the GPI family.
Sequence caution	The sequence AAX88290.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-HAMAP glycolysis Inferred from electronic annotation. Source: UniProtKB-HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Glucose-6-phosphate isomerase HAMAP-Rule MF_00473		PRO_0000180651
Sites
	Active site	355	1	Proton donor By similarity
	Active site	387	1	By similarity
	Active site	515	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QL07 [UniParc]. Last modified November 8, 2005. Version 2. Checksum: B57659BE25B9706F	FASTA	549	61,561
	10 20 30 40 50 60 MKNINPTHTQ AWKSLEAHKA ELSNTTIQDL FKQEKNRFDD YSLTFNNQIL VDFSKNNINQ 70 80 90 100 110 120 TTLSHLRQLA QECALDSAKE AMFTGEKINR TENRAVLHTA LRNRTNTPVL VDGKDVMPEV 130 140 150 160 170 180 NAVLAKMKDF CQRIISGEWK GYTGKAITDV VNIGIGGSDL GPYMVTEALR PYKNHLNMHF 190 200 210 220 230 240 VSNVDGTHIA ETLKKVNPET TLFLVASKTF TTQETMTNAQ SARDWLLKAA KDESAVAKHF 250 260 270 280 290 300 AALSTNAKDV EKFGIDTNNM FEFWDWVGGR YSLWSAIGLS IALSIGFENF EALLNGAHEM 310 320 330 340 350 360 DKHFRTTPIE KNIPTTLALV GLWNTNFLGA QTEAILPYDQ YLHRFAAYFQ QGNMESNGKY 370 380 390 400 410 420 VDRDGNVINN YQTGPIIWGE PGTNGQHAFY QLIHQGTTLI PCDFIAPAQS HNPLADHHNK 430 440 450 460 470 480 LLSNFFAQTE ALAFGKTKEE VEAEFVKAGK SLDDVKNIVP FKVFTGNKPT NSILVQKITP 490 500 510 520 530 540 FTLGALIAMY EHKIFVQGVI FNIFSFDQWG VELGKQLANR ILPELTDSEK VASHDSSTNG LINQFKAWR

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 86-028NP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000057 Genomic DNA. Translation: AAX88290.1. Different initiation.
RefSeq	YP_248950.2. NC_007146.2.
3D structure databases
ProteinModelPortal	Q4QL07.
SMR	Q4QL07. Positions 10-549.
ModBase	Search...
Protein-protein interaction databases
STRING	281310.NTHI1475.
Proteomic databases
PRIDE	Q4QL07.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX88290; AAX88290; NTHI1475.
GeneID	3430724.
KEGG	hit:NTHI1475.
PATRIC	20183047. VBIHaeInf100748_1363.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HOG000261370.
KO	K01810.
OrthoDB	EOG64R61J.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	HINF281310:GJ89-1376-MONOMER.
UniPathway	UPA00109; UER00181.
Family and domain databases
Gene3D	1.10.1390.10. 1 hit.
HAMAP	MF_00473. G6P_isomerase.
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. PTHR11469. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_HAEI8

Accession

Primary (citable) accession number: Q4QL07

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	November 13, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program