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Q4QK67

- GLGB_HAEI8

UniProt

Q4QK67 - GLGB_HAEI8

Protein

1,4-alpha-glucan branching enzyme GlgB

Gene

glgB

Organism
Haemophilus influenzae (strain 86-028NP)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.UniRule annotation

    Catalytic activityi

    Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei405 – 4051NucleophileUniRule annotation
    Active sitei458 – 4581Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-HAMAP
    2. cation binding Source: InterPro
    3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. glycogen biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism

    Enzyme and pathway databases

    BioCyciHINF281310:GJ89-1674-MONOMER.
    UniPathwayiUPA00164.

    Protein family/group databases

    CAZyiCBM48. Carbohydrate-Binding Module Family 48.
    GH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1,4-alpha-glucan branching enzyme GlgBUniRule annotation (EC:2.4.1.18UniRule annotation)
    Alternative name(s):
    1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferaseUniRule annotation
    Alpha-(1->4)-glucan branching enzymeUniRule annotation
    Glycogen branching enzymeUniRule annotation
    Short name:
    BEUniRule annotation
    Gene namesi
    Name:glgBUniRule annotation
    Ordered Locus Names:NTHI1809
    OrganismiHaemophilus influenzae (strain 86-028NP)
    Taxonomic identifieri281310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000002525: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7307301,4-alpha-glucan branching enzyme GlgBPRO_0000260660Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi281310.NTHI1809.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4QK67.
    SMRiQ4QK67. Positions 119-730.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0296.
    HOGENOMiHOG000283037.
    KOiK00700.
    OMAiAKLLFMG.
    OrthoDBiEOG6JX7GT.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPiMF_00685. GlgB.
    InterProiIPR006048. A-amylase_b_C.
    IPR006407. GlgB.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR004193. Glyco_hydro_13_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF02806. Alpha-amylase_C. 1 hit.
    PF02922. CBM_48. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000463. GlgB. 1 hit.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF81296. SSF81296. 2 hits.
    TIGRFAMsiTIGR01515. branching_enzym. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4QK67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTAVTQATI DGFFDASNGD PFATLGMHET EQGIEIRTLL PDANRMVVIE    50
    RESGKEITEL DCVDERGFFV GVIPNCRQFF AYQLQVFWGN EAQIIEDPYR 100
    FHPMIDDLEQ WLLSEGSMLR PYEVLGAHFM ECDGVSGVNF RLWAPNARRV 150
    SIVGDFNYWD GRRHPMRFHP KSGVWELFLP KASLGQLYKF ELIDCYGNLR 200
    LKADPYAFSS QLRPDTASQI SALPNVVEMT EQRRQANQAN QPISIYEVHL 250
    GSWRRNLENN FWLDYDQIAD ELIPYVKEMG FTHIEFLPLS EFPFDGSWGY 300
    QPLGLYSPTS RFGSPEAFRR LVKRAHEAGI NVILDWVPGH FPSDTHGLVA 350
    FDGTALYEHE DPREGYHQDW NTLIYNYGRN EVKNFLSSNA LYWLERFGVD 400
    GIRMDAVASM IYRDYSRAEG EWIPNQYGGR ENLEAIEFLK HTNWKIHSEM 450
    AGAISIAEES TSFAGVTHPS EDGGLGFNFK WNMGWMNDTL AYMKLDPIYR 500
    QYHHNKMTFG MVYQYSENFV LPLSHDEVVH GKYSLLGKMP GDTWQKFANL 550
    RAYYGYMWGY PGKKLLFMGN EFAQGREWNY EESLDWFLLD ENIGGGWHKG 600
    VLKLVKDLNQ IYQKNRPLFE LDNSPEGFDW LVVDDAANSV FAFERRSSNG 650
    ERIIVVSNFT PVPRHNYRIG VNVAGKYEEI LNTDSMYYEG SNVGNFGCVA 700
    SEKIESHGRE NSISVSIPPL ATVYLRLKAK 730
    Length:730
    Mass (Da):84,010
    Last modified:July 19, 2005 - v1
    Checksum:i4510D1E0CBAEFA83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000057 Genomic DNA. Translation: AAX88580.1.
    RefSeqiYP_249240.1. NC_007146.2.

    Genome annotation databases

    EnsemblBacteriaiAAX88580; AAX88580; NTHI1809.
    GeneIDi3431022.
    KEGGihit:NTHI1809.
    PATRICi20183670. VBIHaeInf100748_1672.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000057 Genomic DNA. Translation: AAX88580.1 .
    RefSeqi YP_249240.1. NC_007146.2.

    3D structure databases

    ProteinModelPortali Q4QK67.
    SMRi Q4QK67. Positions 119-730.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 281310.NTHI1809.

    Protein family/group databases

    CAZyi CBM48. Carbohydrate-Binding Module Family 48.
    GH13. Glycoside Hydrolase Family 13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX88580 ; AAX88580 ; NTHI1809 .
    GeneIDi 3431022.
    KEGGi hit:NTHI1809.
    PATRICi 20183670. VBIHaeInf100748_1672.

    Phylogenomic databases

    eggNOGi COG0296.
    HOGENOMi HOG000283037.
    KOi K00700.
    OMAi AKLLFMG.
    OrthoDBi EOG6JX7GT.

    Enzyme and pathway databases

    UniPathwayi UPA00164 .
    BioCyci HINF281310:GJ89-1674-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPi MF_00685. GlgB.
    InterProi IPR006048. A-amylase_b_C.
    IPR006407. GlgB.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR004193. Glyco_hydro_13_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    PF02806. Alpha-amylase_C. 1 hit.
    PF02922. CBM_48. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000463. GlgB. 1 hit.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF81296. SSF81296. 2 hits.
    TIGRFAMsi TIGR01515. branching_enzym. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
      Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
      J. Bacteriol. 187:4627-4636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 86-028NP.

    Entry informationi

    Entry nameiGLGB_HAEI8
    AccessioniPrimary (citable) accession number: Q4QK67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3