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Q4QK64

- SYQ_HAEI8

UniProt

Q4QK64 - SYQ_HAEI8

Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Haemophilus influenzae (strain 86-028NP)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei280 – 2801ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutaminyl-tRNA aminoacylation Source: InterPro
    2. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHINF281310:GJ89-1677-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--tRNA ligaseUniRule annotation (EC:6.1.1.18UniRule annotation)
    Alternative name(s):
    Glutaminyl-tRNA synthetaseUniRule annotation
    Short name:
    GlnRSUniRule annotation
    Gene namesi
    Name:glnSUniRule annotation
    Ordered Locus Names:NTHI1812
    OrganismiHaemophilus influenzae (strain 86-028NP)
    Taxonomic identifieri281310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000002525: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Glutamine--tRNA ligasePRO_0000242870Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi281310.NTHI1812.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4QK64.
    SMRiQ4QK64. Positions 18-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi277 – 2815"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000259233.
    KOiK01886.
    OMAiSREIYID.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    HAMAPiMF_00126. Gln_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR022861. Gln_tRNA_ligase_bac.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00440. glnS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4QK64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSHTETSLG AENTRTHNFI TQIIDEDLAS GKHKSVHTRF PPEPNGYLHI    50
    GHAKSICLNF GLAKEYQGLC NLRFDDTNPV KEDVEYVDSI KADVEWLGFK 100
    WEGEPRYASD YFDALYGYAA ELIKKGLAYV DELSPDEMRE YRGTLTEPGK 150
    NSPYRDRTIE ENLALFEKMK NGEFAEGKAS LRAKIDMASP FMVMRDPVIY 200
    RIKFASHHQT GDKWCIYPMY DFTHCISDAI ERITHSICTL EFQDNRRLYD 250
    WVLENISIER PLPHQYEFSR LNLEGTLTSK RKLLKLVNDE IVDGWNDPRM 300
    PTISGLRRRG YTPASLREFC RRIGVTKQDN VVEYSALEAC IREDLNENAP 350
    RAMAVIDPVR VVIENFESEA VLTAPNHPNR PELGERQLPF TKELYIDRAD 400
    FREEANKQYK RLVLGKEVRL RNAYVIKAER VEKDANGEIT TIFCTYDPET 450
    LGKNPADGRK VKGVIHWVSA VNNHPAEFRL YDRLFTVPNP GAEDDIESVL 500
    NPNSLVIKQG FVEQSLANAE AEKGYQFERE GYFCADSKDS RPEHLVFNLT 550
    VSLKEGF 557
    Length:557
    Mass (Da):64,020
    Last modified:July 19, 2005 - v1
    Checksum:i6C5C1522E9A6D351
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000057 Genomic DNA. Translation: AAX88583.1.
    RefSeqiYP_249243.1. NC_007146.2.

    Genome annotation databases

    EnsemblBacteriaiAAX88583; AAX88583; NTHI1812.
    GeneIDi3431025.
    KEGGihit:NTHI1812.
    PATRICi20183676. VBIHaeInf100748_1675.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000057 Genomic DNA. Translation: AAX88583.1 .
    RefSeqi YP_249243.1. NC_007146.2.

    3D structure databases

    ProteinModelPortali Q4QK64.
    SMRi Q4QK64. Positions 18-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 281310.NTHI1812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX88583 ; AAX88583 ; NTHI1812 .
    GeneIDi 3431025.
    KEGGi hit:NTHI1812.
    PATRICi 20183676. VBIHaeInf100748_1675.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000259233.
    KOi K01886.
    OMAi SREIYID.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci HINF281310:GJ89-1677-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    HAMAPi MF_00126. Gln_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR022861. Gln_tRNA_ligase_bac.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00440. glnS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
      Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
      J. Bacteriol. 187:4627-4636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 86-028NP.

    Entry informationi

    Entry nameiSYQ_HAEI8
    AccessioniPrimary (citable) accession number: Q4QK64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3