ID   CDD_HAEI8               Reviewed;         292 AA.
AC   Q4QK60;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Cytidine deaminase;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
DE            Short=CDA;
GN   Name=cdd; OrderedLocusNames=NTHI1816;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: This enzyme scavenge exogenous and endogenous cytidine
CC       and 2'-deoxycytidine for UMP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; CP000057; AAX88587.1; -; Genomic_DNA.
DR   RefSeq; YP_249247.1; -.
DR   GeneID; 3431029; -.
DR   GenomeReviews; CP000057_GR; NTHI1816.
DR   KEGG; hit:NTHI1816; -.
DR   HOGENOM; Q4QK60; -.
DR   OMA; Q4QK60; FSPCGHC.
DR   BioCyc; HINF281310:NTHI1816-MON; -.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046087; P:cytidine metabolic process; IEA:InterPro.
DR   HAMAP; MF_01558; -; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_Zn_bd.
DR   InterPro; IPR006263; Cyt_deam_dimer.
DR   InterPro; IPR013171; dC_C_deam_Zn_bd.
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR   Pfam; PF08211; dCMP_cyt_deam_2; 1.
DR   TIGRFAMs; TIGR01355; cyt_deam_dimer; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Zinc.
FT   CHAIN         1    292       Cytidine deaminase.
FT                                /FTId=PRO_0000171654.
FT   REGION       88     90       Substrate binding (By similarity).
FT   ACT_SITE    103    103       Proton donor (By similarity).
FT   METAL       101    101       Zinc; catalytic (By similarity).
FT   METAL       128    128       Zinc; catalytic (By similarity).
FT   METAL       131    131       Zinc; catalytic (By similarity).
SQ   SEQUENCE   292 AA;  32565 MW;  6EFFE05200832C74 CRC64;
     MQELIKRTLP QDDALNQAIV NELRSQNWAG FLNYSQVQQL CHNFELTPLK LAMHLLPLAA
     SYSHTAISHF NVGAIAIGEQ GDFYFGANQE FANSAIQQTI HAEQSAISHA WLRNERRISD
     MVVNYTPCGH CRQFMNELHG AEKISIHLPH SQNNPLHSYL PDAFGPKDLD IAAHLLAEEN
     HDLVADHQDD LVNQAILAAN QSHCPYSNSP HGIAILFKNG DVVTGRYAEN AAFNPSLPAL
     QTALNFAYLN DKKLSDIERI VMAEKALKLS HKTMAETLLS TLTSVELEYY SL
//