Reviewed, UniProtKB/Swiss-Prot Q4QK60 (CDD_HAEI8)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	NTHI1816

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Cytidine deaminase HAMAP MF_01558		PRO_0000171654
Regions
	Region	88 – 90	3	Substrate binding By similarity
Sites
	Active site	103	1	Proton donor By similarity
	Metal binding	101	1	Zinc; catalytic By similarity
	Metal binding	128	1	Zinc; catalytic By similarity
	Metal binding	131	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QK60-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 6EFFE05200832C74	FASTA	292	32,565
	10 20 30 40 50 60 MQELIKRTLP QDDALNQAIV NELRSQNWAG FLNYSQVQQL CHNFELTPLK LAMHLLPLAA 70 80 90 100 110 120 SYSHTAISHF NVGAIAIGEQ GDFYFGANQE FANSAIQQTI HAEQSAISHA WLRNERRISD 130 140 150 160 170 180 MVVNYTPCGH CRQFMNELHG AEKISIHLPH SQNNPLHSYL PDAFGPKDLD IAAHLLAEEN 190 200 210 220 230 240 HDLVADHQDD LVNQAILAAN QSHCPYSNSP HGIAILFKNG DVVTGRYAEN AAFNPSLPAL 250 260 270 280 290 QTALNFAYLN DKKLSDIERI VMAEKALKLS HKTMAETLLS TLTSVELEYY SL

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000057 Genomic DNA. Translation: AAX88587.1.
RefSeq	YP_249247.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3431029.
GenomeReviews	Gene locus NTHI1816 in contig CP000057_GR.
KEGG	hit:NTHI1816.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4QK60.
OMA	Q4QK60. FSPCGHC.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI1816-MON.
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR006263. Cyt_deam_dimer. IPR013171. dC_C_deam_Zn_bd. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01355. cyt_deam_dimer. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_HAEI8

Accession

Primary (citable) accession number: Q4QK60

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)