Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q4QJZ3 (GLO2_HAEI8)

Last modified February 9, 2010. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Hydroxyacylglutathione hydrolase
    EC=3.1.2.6
Alternative name(s):
    Glyoxalase II
      Short name=Glx II
Gene names
Name: gloB
Ordered Locus Names: NTHI1896
OrganismHaemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]
Taxonomic identifier281310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Hide | Top

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374

Catalytic activity

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374

Subunit structure

Monomer By similarity. HAMAP MF_01374

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Hide | Top

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionhydroxyacylglutathione hydrolase activity

Inferred from electronic annotation. Source: HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233Hydroxyacylglutathione hydrolase HAMAP MF_01374
PRO_0000309648

Sites

Metal binding521Zinc 1 By similarity
Metal binding541Zinc 1 By similarity
Metal binding561Zinc 2 By similarity
Metal binding571Zinc 2 By similarity
Metal binding1081Zinc 1 By similarity
Metal binding1251Zinc 1 By similarity
Metal binding1251Zinc 2 By similarity
Metal binding1631Zinc 2 By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q4QJZ3-1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 0E66E8BF10F6819A

FASTA23326,359
        10         20         30         40         50         60 
MLFALPALND NYIWLYQREN LPLIIVDLPE TDKLFAWLDK QNATIEAVLL THEHEDHTQG 

        70         80         90        100        110        120 
VSAFKKRYPT VPIYGPQECE KKGATQVVNE GKILTAHYQI DVIPTGGHTK QHVSFLVDNH 

       130        140        150        160        170        180 
LFCGDALFSA GCGRVFTGNY AQMFDGLQRL NTLPDETIVC PAHEYTLGNL AFAETVLVEK 

       190        200        210        220        230 
SAVEKQRIFV ETQRAENKPS LPTTLKLERE INPFLQAKTL EEFTALRKAK DIF

« Hide

Hide | Top

References

[1]"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20."
Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr.
J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000057 Genomic DNA. Translation: AAX88654.1.
RefSeqYP_249314.1.

3D structure databases

SMRQ4QJZ3. Positions 3-233.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4QJZ3.

Genome annotation databases

GeneID3431153.
GenomeReviewsGene locus NTHI1896 in contig CP000057_GR.
KEGGhit:NTHI1896.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0491.
HOGENOMHBG753931.
OMAWCAHEYT.
PhylomeDBQ4QJZ3.

Enzyme and pathway databases

BioCycHINF281310:NTHI1896-MONOMER.

Family and domain databases

HAMAPMF_01374. Glyoxalase_2.
[Tree]
InterProIPR001279. Blactmase-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
TIGRFAMsTIGR03413. GSH_gloB. 1 hit.
ProtoNetSearch...

Hide | Top

Entry information

Entry nameGLO2_HAEI8
AccessionPrimary (citable) accession number: Q4QJZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 19, 2005
Last modified: February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents