Reviewed, UniProtKB/Swiss-Prot Q4QJM6 (GLND_HAEI8)

Names and origin

Protein names

Recommended name:
    [Protein-PII] uridylyltransferase
      Short name=PII uridylyl-transferase
    EC=2.7.7.59
Alternative name(s):
    Uridylyl-removing enzyme
    UTase

Gene names

Name:	glnD
Ordered Locus Names:	NTHI2026

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	863 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein By similarity. HAMAP MF_00277
Catalytic activity	UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII]. HAMAP MF_00277
Sequence similarities	Belongs to the glnD family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	[protein-PII] uridylyltransferase activity Inferred from electronic annotation. Source: HAMAP amino acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 863	863	[Protein-PII] uridylyltransferase HAMAP MF_00277		PRO_0000192737

Sequences

	Sequence		Length	Mass (Da)
	Q4QJM6-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: A3281DCB51B17273	FASTA	863	100,122
	10 20 30 40 50 60 MLFSPTLSSP LTPSAVKIER ENLKQFELEN FSRYSIFELI ENRCDFYDAL LIQLWQEIEL 70 80 90 100 110 120 SEQLGIALIA VGGYGRREMF PLSDLDFLIL VEQTPSPEIE EKITQFIQFL WDCGFEVGNS 130 140 150 160 170 180 VRTLEQCESE GKQDITIATN LLEARFLAGN RPHFDALNEL VKRADFWSKE DFFNAKVQEQ 190 200 210 220 230 240 IERYQRYHNT AYNLEPDIKY SPGGLRDLHL LYWVALRHSG ALTLEAILQS GFIYPQEYQQ 250 260 270 280 290 300 LQESRAFLFK VRFALHLILK RYDNRLLFDR QIKVSELLGF RGEGNPAVEK MMKCFFQALH 310 320 330 340 350 360 RISLISNLLI QHYRENVLPS NQDTVIDQLD DDFQLINQCL CLRNSFVFQE KPARILDLFF 370 380 390 400 410 420 YLTQYEHANI HSDTLRQLQI SLDQLSQKLC EIPAAREKFL RLFNQPNAIK RAFMPMHQYG 430 440 450 460 470 480 VLTAYLPQWQ AIEGLMQFDL FHIYTVDEHT LRVMLKLESF LSQESAQEHP IAHRIFSQLS 490 500 510 520 530 540 DRTLLYIAAL FHDIAKGRGG DHAELGAVDI ADFAQLHGLD RREIDTLAWL VKSHLLMSIT 550 560 570 580 590 600 AQRRDIHDPE VVMNFAEAVQ NQVRLDYLTC LTVADICATN GNLWNSWKRS LFASLYEFTG 610 620 630 640 650 660 RQFSQGMKEL LDYSEKSAEN RKLAQQILMR DYSDITPISI EQLWARCPED YFVRNTPKQI 670 680 690 700 710 720 AWHTSLLVDF VEALLVKISN RFSLGGTEVF IYCQDQPHLF NKVVSTIGAK KFSIHDAQII 730 740 750 760 770 780 TTQDGYVFDS FIITELNGEL VEFDRRRELE QALTLALQSE KLPALSIVPN RQLQHFTVQT 790 800 810 820 830 840 DVRFLQENKK EHTQMELVAL DKAGLLAQVS QIFTELNLNL LNAKITTVGE KAEDFFILTN 850 860 QFGQALDSQQ REILRNVLYR NIG

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000057 Genomic DNA. Translation: AAX88771.1.
RefSeq	YP_249431.1.
3D structure databases
SMR	Q4QJM6. Positions 35-307, 345-504, 481-589, 689-838.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4QJM6.
Genome annotation databases
GeneID	3431275.
GenomeReviews	Gene locus NTHI2026 in contig CP000057_GR.
KEGG	hit:NTHI2026.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2844.
HOGENOM	HBG687872.
OMA	MQHDLFH.
PhylomeDB	Q4QJM6.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI2026-MONOMER.
Family and domain databases
HAMAP	MF_00277. PII_uridylyl-transf. [Tree]
InterPro	IPR002912. ACT_bd. IPR010043. GlnD_Uridyltrans. IPR003607. Metal-dep_PHydrolase_HD_dom. IPR006674. Metal-dep_PHydrolase_HD_sub. IPR002934. Nucleotidyltransferase. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view]
PANTHER	PTHR13734:SF1. GlnD_Uridyltrans. 1 hit.
Pfam	PF01842. ACT. 2 hits. PF08335. GlnD_UR_UTase. 1 hit. PF01966. HD. 1 hit. PF01909. NTP_transf_2. 1 hit. [Graphical view]
PIRSF	PIRSF006288. PII_uridyltransf. 1 hit.
SMART	SM00471. HDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR01693. UTase_glnD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLND_HAEI8

Accession

Primary (citable) accession number: Q4QJM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	July 19, 2005
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)