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Protein

Major vault protein

Gene

LMJF_05_0060

Organism
Leishmania major
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity).By similarity

Keywords - Molecular functioni

Ribonucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Major vault protein
Gene namesi
ORF Names:LMJF_05_0060
OrganismiLeishmania major
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 5

Subcellular locationi

  • Cytoplasm PROSITE-ProRule annotationBy similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Major vault proteinPRO_0000414610Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).By similarity

Protein-protein interaction databases

STRINGi5664.LmjF.05.0060.

Structurei

3D structure databases

ProteinModelPortaliQ4QJJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 11865MVP 1Sequence analysisAdd
BLAST
Repeati119 – 17052MVP 2Sequence analysisAdd
BLAST
Repeati171 – 22353MVP 3Sequence analysisAdd
BLAST
Repeati224 – 27855MVP 4Sequence analysisAdd
BLAST
Repeati280 – 32849MVP 5Sequence analysisAdd
BLAST
Repeati329 – 38052MVP 6Sequence analysisAdd
BLAST
Repeati381 – 43353MVP 7Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 7 MVP (vault) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF6T. Eukaryota.
ENOG410ZCU8. LUCA.
HOGENOMiHOG000255109.
InParanoidiQ4QJJ7.
KOiK17266.
OMAiNKGQDPL.

Family and domain databases

InterProiIPR021870. MVP_shoulder.
IPR002499. Vault_N.
[Graphical view]
PfamiPF11978. MVP_shoulder. 1 hit.
PF01505. Vault. 4 hits.
[Graphical view]
PROSITEiPS51224. MVP. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QJJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSVIRIKR YHYIHILDNN TNVTRTISGP VVYTRKEHET CLFDPCPCVS
60 70 80 90 100
VPPRHYCVVK NPCVRDEAGE VVLESSGQVK LRLGDAEIRF EGEPFPLYPG
110 120 130 140 150
EELDCRDGKG VQKLQLIPPN TGLHVRCVRD FKDADRLVGA GTEWMVAGPQ
160 170 180 190 200
TYIPRVEVVV VEEVKATVIY PNTALMVQAN VNFTDRGGVP RVAGEKWLVR
210 220 230 240 250
ALGAYLQSVE ETVLGLIQGT MLSDLKALRL SAVRSFTDVY GKGRRAGEQW
260 270 280 290 300
QVTLKDAPVH IIDAYEMKVA DVAAVSLSAK EYVIIHHPVD DTGHNRFGET
310 320 330 340 350
LVRRGECTFF LQPGETMPRG VEQVLVVGKE EALLLEAVCE YRDRGEKRQP
360 370 380 390 400
GSRWMVRGPL EYIPANEVKL LEHRRMMALD KNEGIYVMNT TTGEVRAVIG
410 420 430 440 450
KPYMLDVNEV LWEKHLPLAV EELLESPNGS IQTSERNPGF VSHREKYRIV
460 470 480 490 500
RFNVQHNAAV QIYDYRKKQP RIVLGPNLVM LAPHEEFTVL SLSGGTPKVP
510 520 530 540 550
NSLQSLQLFL GPRFSSDTIV VETSDHARLR LRLSYNWYFD IDRVNPSQRT
560 570 580 590 600
FSVPDFIGDC CKTIASRVRG AVASEDFDSF HRNSAKIIRT AVFGVDETGE
610 620 630 640 650
TKKNLRFTAN DFVVTNIDVQ SSEPTDEKTR DSLQKSVQLA IEITTKSQEA
660 670 680 690 700
AARHGNELKD QEAKGQLERQ KLLDKIEVEN ARTKWLELQA KSEAVQASGQ
710 720 730 740 750
SVAEAKARAE ALLIEVRSEM QQAEMRARAY RISAEAELQK LQQRQALELE
760 770 780 790 800
YTQRQNEIDV SKARAAAEAE AEKVKRMVDC IGRDTLVAIA RAGPETQVKL
810 820 830
LSSLGLKGYL ITDGNSPVNL FGTAQGMIGE PKK
Length:833
Mass (Da):93,301
Last modified:July 19, 2005 - v1
Checksum:i05EC673FEB919D39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796401 Genomic DNA. Translation: CAJ01922.1.
RefSeqiXP_001687482.1. XM_001687430.1.

Genome annotation databases

EnsemblProtistsiLmjF.05.0060:mRNA; LmjF.05.0060:pep; LmjF.05.0060.
GeneIDi5648865.
KEGGilma:LMJF_05_0060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796401 Genomic DNA. Translation: CAJ01922.1.
RefSeqiXP_001687482.1. XM_001687430.1.

3D structure databases

ProteinModelPortaliQ4QJJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.05.0060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.05.0060:mRNA; LmjF.05.0060:pep; LmjF.05.0060.
GeneIDi5648865.
KEGGilma:LMJF_05_0060.

Phylogenomic databases

eggNOGiENOG410IF6T. Eukaryota.
ENOG410ZCU8. LUCA.
HOGENOMiHOG000255109.
InParanoidiQ4QJJ7.
KOiK17266.
OMAiNKGQDPL.

Family and domain databases

InterProiIPR021870. MVP_shoulder.
IPR002499. Vault_N.
[Graphical view]
PfamiPF11978. MVP_shoulder. 1 hit.
PF01505. Vault. 4 hits.
[Graphical view]
PROSITEiPS51224. MVP. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.

Entry informationi

Entry nameiMVP_LEIMA
AccessioniPrimary (citable) accession number: Q4QJJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: July 19, 2005
Last modified: February 17, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.