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Protein

Histone H4

Gene

LMJF_06_0010

Organism
Leishmania major
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4UniRule annotation
Gene namesi
ORF Names:LMJF_06_0010Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiTriTrypDB:LmjF.06.0010

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi5664.LmjF.06.0010

Structurei

3D structure databases

ProteinModelPortaliQ4QJ78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
HOGENOMiHOG000234654
InParanoidiQ4QJ78
KOiK11254
OMAiFTFINIT

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR001951 Histone_H4
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Q4QJ78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKGKRSADA KSSQKRQKKV LRDNIRGITR GCVRRMARRG GVKRISSEVY
60 70 80 90 100
GEVRRVLKAY LEDIVRCSTA YTEYARKKTV TACDVVNALR QKGHILYGYA
Length:100
Mass (Da):11,366
Last modified:July 19, 2005 - v1
Checksum:i3A4F54F61861715C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796402 Genomic DNA Translation: CAJ02044.1
RefSeqiXP_001680770.1, XM_001680718.1

Genome annotation databases

EnsemblProtistsiLmjF.06.0010:mRNA; LmjF.06.0010:pep; LmjF.06.0010
GeneDBiLmjF.06.0010:pep
GeneIDi5649156
KEGGilma:LMJF_06_0010

Similar proteinsi

Entry informationi

Entry nameiQ4QJ78_LEIMA
AccessioniPrimary (citable) accession number: Q4QJ78
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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