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Q4QHI7

- Q4QHI7_LEIMA

UniProt

Q4QHI7 - Q4QHI7_LEIMA

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Protein

Isocitrate dehydrogenase [NADP]

Gene
LMJF_10_0290
Organism
Leishmania major
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Substrate By similarity
Binding sitei108 – 1081NADP By similarityUniRule annotation
Binding sitei135 – 1351Substrate By similarity
Binding sitei158 – 1581Substrate By similarityUniRule annotation
Sitei165 – 1651Critical for catalysis By similarityUniRule annotation
Sitei236 – 2361Critical for catalysis By similarityUniRule annotation
Metal bindingi276 – 2761Magnesium or manganese By similarityUniRule annotation
Binding sitei284 – 2841NADP By similarityUniRule annotation
Metal bindingi299 – 2991Magnesium or manganese By similarityUniRule annotation
Binding sitei352 – 3521NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1033NADP By similarityUniRule annotation
Nucleotide bindingi334 – 3396NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:LMJF_10_0290Imported
OrganismiLeishmania major
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000000542: Chromosome 10

Structurei

3D structure databases

ProteinModelPortaliQ4QHI7.
SMRiQ4QHI7. Positions 27-433.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1267Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QHI7-1 [UniParc]FASTAAdd to Basket

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MFRHVSAASA SSLVAARSFS STNVYLDKRI KVKNEVVDMD GDEMTRIIWS    50
FIKEKLILPY VDVPINYFDL SVTNRDATND KVTVEAAEAV KKCNVGIKCA 100
TITPDEARVK EFNLKKMWKS PNGTIRNILG GTVFREPIIV SNIPRIVPQW 150
HNPIVVGRHA FGDQYKATDA VLKPGKLQLV HTPADGSAPT TLDVYDFKGE 200
GVGLAMYNTK ESIEGFAKSC FQYALMRKYP LVLTTKNTIL KKYDGMFLQT 250
FQRMYDEQYK ADFEKAGITY NHRLIDDQVA QMIKGEGGFV WACKNYDGDV 300
QSDIVAQGFG SLGLMTSVLM CPDGKTIEAE AAHGTVTRHY RQHQQGKETS 350
TNSVASIYAW TRGLAHRGKL DGNSDLVKFS ETLERVVVKA IEDGHMTKDL 400
ALCVYGSSGV KREHYETTEQ FLDSVDTALK KAMSA 435
Length:435
Mass (Da):48,490
Last modified:July 19, 2005 - v1
Checksum:i685D1D34CB6A5CC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796406 Genomic DNA. Translation: CAJ02471.1.
RefSeqiXP_001681361.1. XM_001681309.1.

Genome annotation databases

EnsemblProtistsiLmjF.10.0290:mRNA; LmjF.10.0290:pep; LmjF.10.0290.
GeneIDi5649629.
KEGGilma:LMJF_10_0290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796406 Genomic DNA. Translation: CAJ02471.1 .
RefSeqi XP_001681361.1. XM_001681309.1.

3D structure databases

ProteinModelPortali Q4QHI7.
SMRi Q4QHI7. Positions 27-433.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi LmjF.10.0290:mRNA ; LmjF.10.0290:pep ; LmjF.10.0290 .
GeneIDi 5649629.
KEGGi lma:LMJF_10_0290.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/Friedlin.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported.

Entry informationi

Entry nameiQ4QHI7_LEIMA
AccessioniPrimary (citable) accession number: Q4QHI7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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