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Q4QHI7

- Q4QHI7_LEIMA

UniProt

Q4QHI7 - Q4QHI7_LEIMA

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Protein

Isocitrate dehydrogenase [NADP]

Gene

LMJF_10_0290

Organism
Leishmania major
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031SubstrateUniRule annotation
Binding sitei108 – 1081NADPUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Binding sitei158 – 1581SubstrateUniRule annotation
Sitei165 – 1651Critical for catalysisUniRule annotation
Sitei236 – 2361Critical for catalysisUniRule annotation
Metal bindingi276 – 2761Magnesium or manganeseUniRule annotation
Binding sitei284 – 2841NADPUniRule annotation
Metal bindingi299 – 2991Magnesium or manganeseUniRule annotation
Binding sitei352 – 3521NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1033NADPUniRule annotation
Nucleotide bindingi334 – 3396NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:LMJF_10_0290Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000000542: Chromosome 10

Structurei

3D structure databases

ProteinModelPortaliQ4QHI7.
SMRiQ4QHI7. Positions 27-433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1267Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
InParanoidiQ4QHI7.
KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QHI7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRHVSAASA SSLVAARSFS STNVYLDKRI KVKNEVVDMD GDEMTRIIWS
60 70 80 90 100
FIKEKLILPY VDVPINYFDL SVTNRDATND KVTVEAAEAV KKCNVGIKCA
110 120 130 140 150
TITPDEARVK EFNLKKMWKS PNGTIRNILG GTVFREPIIV SNIPRIVPQW
160 170 180 190 200
HNPIVVGRHA FGDQYKATDA VLKPGKLQLV HTPADGSAPT TLDVYDFKGE
210 220 230 240 250
GVGLAMYNTK ESIEGFAKSC FQYALMRKYP LVLTTKNTIL KKYDGMFLQT
260 270 280 290 300
FQRMYDEQYK ADFEKAGITY NHRLIDDQVA QMIKGEGGFV WACKNYDGDV
310 320 330 340 350
QSDIVAQGFG SLGLMTSVLM CPDGKTIEAE AAHGTVTRHY RQHQQGKETS
360 370 380 390 400
TNSVASIYAW TRGLAHRGKL DGNSDLVKFS ETLERVVVKA IEDGHMTKDL
410 420 430
ALCVYGSSGV KREHYETTEQ FLDSVDTALK KAMSA
Length:435
Mass (Da):48,490
Last modified:July 19, 2005 - v1
Checksum:i685D1D34CB6A5CC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796406 Genomic DNA. Translation: CAJ02471.1.
RefSeqiXP_001681361.1. XM_001681309.1.

Genome annotation databases

EnsemblProtistsiLmjF.10.0290:mRNA; LmjF.10.0290:pep; LmjF.10.0290.
GeneIDi5649629.
KEGGilma:LMJF_10_0290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796406 Genomic DNA. Translation: CAJ02471.1 .
RefSeqi XP_001681361.1. XM_001681309.1.

3D structure databases

ProteinModelPortali Q4QHI7.
SMRi Q4QHI7. Positions 27-433.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi LmjF.10.0290:mRNA ; LmjF.10.0290:pep ; LmjF.10.0290 .
GeneIDi 5649629.
KEGGi lma:LMJF_10_0290.

Phylogenomic databases

HOGENOMi HOG000019858.
InParanoidi Q4QHI7.
KOi K00031.
OMAi KNTIMKV.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported.

Entry informationi

Entry nameiQ4QHI7_LEIMA
AccessioniPrimary (citable) accession number: Q4QHI7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3