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Q4QHG4 (GPDA_LEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal

EC=1.1.1.8
Gene names
Name:GPD
ORF Names:LmjF10.0510, LmjF_10_0510
OrganismLeishmania major [Reference proteome]
Taxonomic identifier5664 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH. HAMAP-Rule MF_00394

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00394

Subcellular location

Glycosome By similarity HAMAP-Rule MF_00394.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal HAMAP-Rule MF_00394
PRO_0000262291

Regions

Nucleotide binding23 – 286NAD By similarity
Region275 – 2762Substrate binding By similarity
Motif365 – 3673Microbody targeting signal Potential

Sites

Active site2111Proton acceptor Potential
Binding site981NAD By similarity
Binding site1261Substrate By similarity
Binding site1581NAD; via amide nitrogen By similarity
Binding site2751NAD By similarity
Binding site2971NAD; via amide nitrogen By similarity
Binding site3011NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4QHG4 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 49F47113F30B5657

FASTA36739,299
        10         20         30         40         50         60 
MISTKRHINT NELLHLSKAV VFGSGAFGTA LAMVLSKKCR EVCVWHIKEE EARLVNEKRE 

        70         80         90        100        110        120 
NDLYLRGVQL ASNIIFTSDV DEAYKGAELI LFVIPTQFLR GFFQKSGGNL IAYAKARQVP 

       130        140        150        160        170        180 
VLVCTKGIER STLKFPAQIV GEFFPSNLLS VLAGPSFAIE VATGVFTCVS VASADINVAR 

       190        200        210        220        230        240 
RLQRIMTTGD RSFVCWATTD TVGCEVASAV KNVLAIGSGV ANGLGMGLNA RAALITRGLL 

       250        260        270        280        290        300 
EIRDLTAALG GDGSAIFGLA GFGDLQLTCS SELSRNFTVG KKLGKGLSLE EIQRTSKAVA 

       310        320        330        340        350        360 
EGVATAEPLV RLAQQLKVTM PLCQQIYEVV YKKKNPRAAI ADLLSCGLQD EGLPPLFKKS 


AATPSKL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR796406 Genomic DNA. Translation: CAJ02624.1.
RefSeqXP_001681384.1. XM_001681332.1.

3D structure databases

ProteinModelPortalQ4QHG4.
SMRQ4QHG4. Positions 11-358.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5649653.
KEGGlma:LMJF_10_0510.

Phylogenomic databases

HOGENOMHOG000246853.
KOK00006.
OMACHRAFLP.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00394. NAD_Glyc3P_dehydrog.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPDA_LEIMA
AccessionPrimary (citable) accession number: Q4QHG4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families