ID   Q4QGT7_LEIMA            Unreviewed;       192 AA.
AC   Q4QGT7;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 99.
DE   SubName: Full=Ribonuclease mar1 {ECO:0000313|EMBL:CAJ02379.1};
GN   Name=MAR1 {ECO:0000313|EMBL:CAJ02379.1};
GN   ORFNames=LMJF_12_0060 {ECO:0000313|EMBL:CAJ02379.1};
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02379.1, ECO:0000313|Proteomes:UP000000542};
RN   [1] {ECO:0007829|PDB:1XN4}
RP   X-RAY CRYSTALLOGRAPHY (3.80 ANGSTROMS).
RX   PubMed=16199669; DOI=10.1110/ps.051783005;
RA   Caruthers J., Zucker F., Worthey E., Myler P.J., Buckner F.,
RA   Van Voorhuis W., Mehlin C., Boni E., Feist T., Luft J., Gulde S.,
RA   Lauricella A., Kaluzhniy O., Anderson L., Le Trong I., Holmes M.A.,
RA   Earnest T., Soltis M., Hodgson K.O., Hol W.G., Merritt E.A.;
RT   "Crystal structures and proposed structural/functional classification of
RT   three protozoan proteins from the isochorismatase superfamily.";
RL   Protein Sci. 14:2887-2894(2005).
RN   [2] {ECO:0000313|EMBL:CAJ02379.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA   Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA   De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA   Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA   Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA   Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA   Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA   Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA   Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA   Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA   Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA   Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA   Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA   Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA   Barrell B., Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
RN   [3] {ECO:0000313|EMBL:CAJ02379.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SIMILARITY: Belongs to the isochorismatase family.
CC       {ECO:0000256|ARBA:ARBA00006336}.
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DR   EMBL; FR796408; CAJ02379.1; -; Genomic_DNA.
DR   RefSeq; XP_001681611.1; XM_001681559.1.
DR   PDB; 1XN4; X-ray; 3.80 A; A=1-192.
DR   PDBsum; 1XN4; -.
DR   AlphaFoldDB; Q4QGT7; -.
DR   SMR; Q4QGT7; -.
DR   STRING; 5664.Q4QGT7; -.
DR   EnsemblProtists; CAJ02379; CAJ02379; LMJF_12_0060.
DR   GeneID; 5649891; -.
DR   KEGG; lma:LMJF_12_0060; -.
DR   VEuPathDB; TriTrypDB:LmjF.12.0060; -.
DR   VEuPathDB; TriTrypDB:LMJFC_120005900; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_120005700; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_120006500; -.
DR   eggNOG; KOG4044; Eukaryota.
DR   HOGENOM; CLU_066901_0_1_1; -.
DR   InParanoid; Q4QGT7; -.
DR   OMA; LRHIGCT; -.
DR   EvolutionaryTrace; Q4QGT7; -.
DR   Proteomes; UP000000542; Chromosome 12.
DR   Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   PANTHER; PTHR14119; HYDROLASE; 1.
DR   PANTHER; PTHR14119:SF3; ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:1XN4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT   DOMAIN          13..159
FT                   /note="Isochorismatase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00857"
SQ   SEQUENCE   192 AA;  21586 MW;  1E6B0E8CF0813E98 CRC64;
     MSRLMPHYSK GKTAFLCVDL QEAFSKRIEN FANCVFVANR LARLHELVPE NTKYIVTEHY
     PKGLGRIVPG ITLPQTAHLI EKTRFSCIVP QVEELLEDVD NAVVFGIEGH ACILQTVADL
     LDMNKRVFLP KDGLGSQKKT DFKAAMKLMG SWSPNCEITT SESILLQMTK DAMDPNFKKI
     SKLLKEEPPI PL
//