Q4QGN9 (Q4QGN9_LEIMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase RuleBase RU000612
EC=5.3.1.9 RuleBase RU000612

Gene names

Name:	PGI EMBL CAJ02649.1
Synonyms:	pgi EMBL CAF05845.1
ORF Names:	LMJF_12_0530 EMBL CAJ02649.1

Organism

Leishmania major

Taxonomic identifier

5664 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	605 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. RuleBase RU000612
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. RuleBase RU000612
Subcellular location	Cytoplasm By similarity RuleBase RU003642.
Sequence similarities	Belongs to the GPI family. RuleBase RU000612

Ontologies

Keywords
Biological process	Gluconeogenesis RuleBase RU000612 Glycolysis RuleBase RU000612
Molecular function	Isomerase RuleBase RU000612 EMBL CAJ02649.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4QGN9 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 2E0D47A5C163B487	FASTA	605	67,169
	10 20 30 40 50 60 MSDYLSKLKE YVLESTEVNG CAPSMATSTF NAPYEVARRT KMLGATDSSL LSLPAWKRLQ 70 80 90 100 110 120 SLYEKHGNES ILSHFESDHQ RFGRYSIEVG LHSEDNFLFL DYSKSHINDE IKDALVALAE 130 140 150 160 170 180 ERGVRAFAKA MFDGQRVNST EDRAVLHVAL RNRSNRPIIV DGKDVMTDVN NVLAQMKNFT 190 200 210 220 230 240 EKVRSGEWKG QTGKSISNIV NIGIGGSDLG PVMVTEALKP FSKRDMHCFF VSNVDGTHMA 250 260 270 280 290 300 EVLKQVNLEE TIFIIASKTF TTQETLTNAM SARNALMDYL KAHNISTDGA VAKHFVALST 310 320 330 340 350 360 NTEKVREFGI DTVNMFVFWD WVGGRYSVWS AIGLSVMLSI GYDNFVEFLT GAHVMDNHFA 370 380 390 400 410 420 STPTEQNLPM MLALVGIWYN NFFGAETEAV LPYDQYLWRL PAYLQQLDME SNGKGVTKKS 430 440 450 460 470 480 AAVAVQTGSI IFGEAGTNGQ HAFYQLIHQG TKIIPCDFIG CVQTQNRVGD HHRILMSNFF 490 500 510 520 530 540 AQTEALMVGK SAEEVRQELV KSGMSGEAME RMIPHKTFTG NRPSNSILVN ALTPRALGAI 550 560 570 580 590 600 IAMYEHKVLV QGAIWGINSY DQWGVELGKV LAKSILPQLK SGNIVSDHDG STNGLINMFN TRAHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the kinetoplastid parasite, Leishmania major." Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G. , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J. Science 309:436-442(2005) [PubMed: 16020728] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Friedlin and MHOM/IL/81/Friedlin.
[2]	"Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD)." Mauricio I.L., Yeo M., Baghaei M., Doto D., Pratlong F., Zemanova E., Dedet J.P., Lukes J., Miles M.A. Int. J. Parasitol. 36:757-769(2006) [PubMed: 16725143] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MHOM/SU/1973/5-ASKH EMBL CAF05845.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ620646 Genomic DNA. Translation: CAF05845.1. FR796408 Genomic DNA. Translation: CAJ02649.1.
RefSeq	XP_001681659.1. XM_001681607.1.
3D structure databases
ProteinModelPortal	Q4QGN9.
SMR	Q4QGN9. Positions 49-604.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	LmjF.12.0530:mRNA; LmjF.12.0530:pep; LmjF.12.0530.
GeneID	5649944.
GenomeReviews	Gene locus PGI in contig FR796408_GR.
KEGG	lma:LmjF12.0530.
Organism-specific databases
EuPathDB	EupathDB:LmjF.12.0530.
Phylogenomic databases
HOGENOM	HBG352954.
OMA	GPKIVSQ.
PhylomeDB	Q4QGN9.
ProtClustDB	CLSZ2430346.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4QGN9_LEIMA

Accession

Primary (citable) accession number: Q4QGN9
Secondary accession number(s): Q2PDC9

Entry history

Integrated into UniProtKB/TrEMBL:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)