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Protein

NADH-cytochrome b5 reductase

Gene

LMJF_15_0050

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.UniRule annotation

Cofactori

FADUniRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationImported

Keywords - Ligandi

FADUniRule annotationSAAS annotation, Flavoprotein, NADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-cytochrome b5 reductaseUniRule annotation (EC:1.6.2.2UniRule annotation)
Gene namesi
ORF Names:LMJF_15_0050Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 15

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.15.0050.

Structurei

3D structure databases

ProteinModelPortaliQ4QFH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 130105FAD-binding FR-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation
Contains 1 FAD-binding FR-type domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0534. Eukaryota.
COG0543. LUCA.
HOGENOMiHOG000175005.
InParanoidiQ4QFH9.
KOiK00326.
OMAiMPVASCI.

Family and domain databases

InterProiIPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR001834. NADH-Cyt_B5_reductase.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00406. CYTB5RDTASE.
PR00371. FPNCR.
SUPFAMiSSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QFH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSTRQQSER LAATCAKKPV DTFSPDAYKP FKLISSRYES HDTRRFYFAL
60 70 80 90 100
DSPDDSFYMP VASCIIAKYT DADGKDVARP YTPISSNSTK GHFELVVKKY
110 120 130 140 150
PKGKMGNYLF SMQPGDELLV KGPFEKFAYK PNMWKHVGMI AGGTGIAPMY
160 170 180 190 200
QVLRAVLENP RDKTNISLIY ANNQRRDILL ANELIEMQKV YTNFNMYLTL
210 220 230 240 250
LEVPHRWLGG IGYVNSAMVT TFMPKPGEKN TKILVCGPPP MMQAISGDKL
260 270
FEPGKPPQQG QVGGLLKTLG YTEEQVFKY
Length:279
Mass (Da):31,512
Last modified:July 19, 2005 - v1
Checksum:i134608CC3503B049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796411 Genomic DNA. Translation: CAJ03229.1.
RefSeqiXP_001681919.1. XM_001681867.1.

Genome annotation databases

EnsemblProtistsiLmjF.15.0050:mRNA; LmjF.15.0050:pep; LmjF.15.0050.
GeneIDi5650364.
KEGGilma:LMJF_15_0050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796411 Genomic DNA. Translation: CAJ03229.1.
RefSeqiXP_001681919.1. XM_001681867.1.

3D structure databases

ProteinModelPortaliQ4QFH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.15.0050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.15.0050:mRNA; LmjF.15.0050:pep; LmjF.15.0050.
GeneIDi5650364.
KEGGilma:LMJF_15_0050.

Phylogenomic databases

eggNOGiKOG0534. Eukaryota.
COG0543. LUCA.
HOGENOMiHOG000175005.
InParanoidiQ4QFH9.
KOiK00326.
OMAiMPVASCI.

Family and domain databases

InterProiIPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR001834. NADH-Cyt_B5_reductase.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00406. CYTB5RDTASE.
PR00371. FPNCR.
SUPFAMiSSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.

Entry informationi

Entry nameiQ4QFH9_LEIMA
AccessioniPrimary (citable) accession number: Q4QFH9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 6, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.