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Protein
Submitted name:

ADP-ribosylation factor-like protein 1

Gene

ARL-1

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • protein targeting to lysosome Source: GeneDB
  • regulation of endocytosis Source: GeneDB
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ADP-ribosylation factor-like protein 1Imported
Gene namesi
Name:ARL-1Imported
ORF Names:LMJF_17_0070Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

  • trans-Golgi network Source: GeneDB
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 – 83InterchainCombined sources

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.17.0070.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X77X-ray2.10A/B1-187[»]
ProteinModelPortaliQ4QEJ1.
SMRiQ4QEJ1. Positions 19-183.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4QEJ1.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000163691.
InParanoidiQ4QEJ1.
KOiK07942.
OMAiGIVFTKL.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QEJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAWLASLKQ TLGLLPADRK IRVLMLGLDN AGKTSILYRL HLGDVVTTVP
60 70 80 90 100
TVGVNLETLQ YKNISFEVWD LGGQTGVRPY WRCYFSDTDA VIYVVDSTDR
110 120 130 140 150
DRMGVAKHEL YALLDEDELR KSLLLIFANK QDLPDAASEA EIAEQLGVSS
160 170 180
IMNRTWTIVK SSSKTGDGLV EGMDWLVERL REQGLGA
Length:187
Mass (Da):20,791
Last modified:July 19, 2005 - v1
Checksum:i3E1628C669EDA637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796413 Genomic DNA. Translation: CAJ03412.1.
RefSeqiXP_001682257.1. XM_001682205.1.

Genome annotation databases

EnsemblProtistsiLmjF.17.0070:mRNA; LmjF.17.0070:pep; LmjF.17.0070.
GeneIDi5650731.
KEGGilma:LMJF_17_0070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796413 Genomic DNA. Translation: CAJ03412.1.
RefSeqiXP_001682257.1. XM_001682205.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X77X-ray2.10A/B1-187[»]
ProteinModelPortaliQ4QEJ1.
SMRiQ4QEJ1. Positions 19-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.17.0070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.17.0070:mRNA; LmjF.17.0070:pep; LmjF.17.0070.
GeneIDi5650731.
KEGGilma:LMJF_17_0070.

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000163691.
InParanoidiQ4QEJ1.
KOiK07942.
OMAiGIVFTKL.

Miscellaneous databases

EvolutionaryTraceiQ4QEJ1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.
  2. "Crystal structure of Leishmania major ADP-ribosylation factor-like 1 and a classification of related GTPase family members in this Kinetoplastid."
    Fleming J.R., Dawson A., Hunter W.N.
    Mol. Biochem. Parasitol. 174:141-144(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), DISULFIDE BONDS.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.

Entry informationi

Entry nameiQ4QEJ1_LEIMA
AccessioniPrimary (citable) accession number: Q4QEJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 11, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.