Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4QDX3 (CISY_LEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable citrate synthase, mitochondrial

EC=2.3.3.16
Gene names
ORF Names:LmjF18.0680, LmjF_18_0680
OrganismLeishmania major [Reference proteome]
Taxonomic identifier5664 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 470Probable citrate synthase, mitochondrialPRO_0000291606

Sites

Active site2971 By similarity
Active site3511 By similarity
Active site4061 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4QDX3 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 5257C02EC31A2E0A

FASTA47052,329
        10         20         30         40         50         60 
MRAVRCSLIR GVAGLRMASS ALDEMKEQML RRWKEDQKKI DDLRKKHGHE KLCDATIDAV 

        70         80         90        100        110        120 
YGGMRGITGL VYEPSLLDPA EGIRFRGLTI LECQEMLPKA PGGKEPLPEA MFWLLMTGEV 

       130        140        150        160        170        180 
PTEEQVRGLN AELHRRADPE AIAAAQKAIA ALPRNAHPMT AFSVGVLALQ SYSKFAAAYA 

       190        200        210        220        230        240 
AGKSNKKTYW EYALEDSLDM LARTPTVAAM IYNRETKGQV ELAAPSNSDL DWAANFAKMM 

       250        260        270        280        290        300 
GYQDEEFWEC MRLYLSVHAD HEGGNVSAHT TTLVASALSD PYLAFSAGLN GLAGPLHGLA 

       310        320        330        340        350        360 
NQEVLNYLLS MQERVKADGV NMHDEAALEK ALSNYTWELL NSGQVVPGYG HAVLRKVDPR 

       370        380        390        400        410        420 
YTCQRNFCLR HKFDDDLFKL VNTIYSIMPG ILKEHGKTKN PYPNVDAHSG VLLQHYGLTE 

       430        440        450        460        470 
QNYYTVLFGL SRQMGVLAGV VWDRLQGRPL ERPKSITTEM LAKKYLCNSL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR796414 Genomic DNA. Translation: CAJ03695.1.
RefSeqXP_001682475.1. XM_001682423.1.

3D structure databases

ProteinModelPortalQ4QDX3.
SMRQ4QDX3. Positions 24-463.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5650994.
KEGGlma:LMJF_18_0680.

Phylogenomic databases

HOGENOMHOG000130831.
KOK01647.
OMAELIYEDC.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_LEIMA
AccessionPrimary (citable) accession number: Q4QDX3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways