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Protein

Probable citrate synthase, mitochondrial

Gene

LmjF18.0680

Organism
Leishmania major
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable citrate synthase, mitochondrial (LmjF18.0680)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei297PROSITE-ProRule annotation1
Active sitei351PROSITE-ProRule annotation1
Active sitei406PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
ORF Names:LmjF18.0680, LmjF_18_0680
OrganismiLeishmania major
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiTriTrypDB:LmjF.18.0680

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000291606? – 470Probable citrate synthase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5664.LmjF.18.0680

Structurei

3D structure databases

ProteinModelPortaliQ4QDX3
SMRiQ4QDX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2617 Eukaryota
COG0372 LUCA
HOGENOMiHOG000130831
InParanoidiQ4QDX3
KOiK01647
OMAiTVGWCAQ

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 2 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR010109 Citrate_synthase_euk
IPR036969 Citrate_synthase_sf
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
TIGRFAMsiTIGR01793 cit_synth_euk, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QDX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVRCSLIR GVAGLRMASS ALDEMKEQML RRWKEDQKKI DDLRKKHGHE
60 70 80 90 100
KLCDATIDAV YGGMRGITGL VYEPSLLDPA EGIRFRGLTI LECQEMLPKA
110 120 130 140 150
PGGKEPLPEA MFWLLMTGEV PTEEQVRGLN AELHRRADPE AIAAAQKAIA
160 170 180 190 200
ALPRNAHPMT AFSVGVLALQ SYSKFAAAYA AGKSNKKTYW EYALEDSLDM
210 220 230 240 250
LARTPTVAAM IYNRETKGQV ELAAPSNSDL DWAANFAKMM GYQDEEFWEC
260 270 280 290 300
MRLYLSVHAD HEGGNVSAHT TTLVASALSD PYLAFSAGLN GLAGPLHGLA
310 320 330 340 350
NQEVLNYLLS MQERVKADGV NMHDEAALEK ALSNYTWELL NSGQVVPGYG
360 370 380 390 400
HAVLRKVDPR YTCQRNFCLR HKFDDDLFKL VNTIYSIMPG ILKEHGKTKN
410 420 430 440 450
PYPNVDAHSG VLLQHYGLTE QNYYTVLFGL SRQMGVLAGV VWDRLQGRPL
460 470
ERPKSITTEM LAKKYLCNSL
Length:470
Mass (Da):52,329
Last modified:July 19, 2005 - v1
Checksum:i5257C02EC31A2E0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796414 Genomic DNA Translation: CAJ03695.1
RefSeqiXP_001682475.1, XM_001682423.1

Genome annotation databases

GeneDBiLmjF.18.0680:pep
GeneIDi5650994
KEGGilma:LMJF_18_0680

Similar proteinsi

Entry informationi

Entry nameiCISY_LEIMA
AccessioniPrimary (citable) accession number: Q4QDX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health