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Q4QBH1 (Q4QBH1_LEIMA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase RuleBase RU000493

EC=5.2.1.8 RuleBase RU000493
Gene names
Name:CYP11 EMBL CAJ03831.1
ORF Names:LMJF_23_0050 EMBL CAJ03831.1
OrganismLeishmania major [Reference proteome]
Taxonomic identifier5664 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins By similarity. RuleBase RU000493

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity. RuleBase RU004223

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0). RuleBase RU000493 SAAS SAAS002130

Sequence similarities

Belongs to the cyclophilin-type PPIase family.

Contains 1 PPIase cyclophilin-type domain. RuleBase RU003420

Contains PPIase cyclophilin-type domain. SAAS SAAS020892

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site741Phosphate PDB 2HQJ

Sequences

Sequence LengthMass (Da)Tools
Q4QBH1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 69AAC0FBD9533143

FASTA29531,497
        10         20         30         40         50         60 
MSRTSVPPKV GQRPGIGVEK TTNPKVFFDI SIDNKAAGRI VMELYADTVP KTAENFRALC 

        70         80         90        100        110        120 
TGEKGKGRSG KPLHYKSSVF HRVIPNFMIQ GGDFTRGNGT GGESIYGTTF RDESFSGKAG 

       130        140        150        160        170        180 
RHTGLGCLSM ANAGPNTNGS QFFICTAATP WLDGKHVVFG RVIDGLDVVK KVERLGSSSG 

       190        200        210        220        230        240 
KTRSRIVVSD CGEVAADKSK GQRPPQQQHQ PAKASADMKR AADKKAVAEK LLASSPAAEG 

       250        260        270        280        290 
QKALSAKKET PPQVAAPSEA KKRMRAVDEE ETRLARLREK KAKLAALRSS AAGNE 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the kinetoplastid parasite, Leishmania major."
Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G. expand/collapse author list , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MHOM/IL/81/Friedlin.
[2]"Cyclophilin from Leishmania major."
Arakaki T.L., Merritt E.A.
Submitted (JUL-2006) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 22-199 IN COMPLEX WITH PHOSPHATE.
[3]"Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania."
Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A., Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C.
Genome Res. 21:2129-2142(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Friedlin EMBL CAJ03831.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR796419 Genomic DNA. Translation: CAJ03831.1.
RefSeqXP_001683327.1. XM_001683275.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2HQJX-ray2.00A22-199[»]
ProteinModelPortalQ4QBH1.
SMRQ4QBH1. Positions 22-199.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsLmjF.23.0050:mRNA; LmjF.23.0050:pep; LmjF.23.0050.
GeneID5651954.
KEGGlma:LMJF_23_0050.

Phylogenomic databases

HOGENOMHOG000065980.
KOK01802.
OMALGCLSMA.

Family and domain databases

Gene3D2.40.100.10. 1 hit.
InterProIPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSPR00153. CSAPPISMRASE.
SUPFAMSSF50891. SSF50891. 1 hit.
PROSITEPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ4QBH1.

Entry information

Entry nameQ4QBH1_LEIMA
AccessionPrimary (citable) accession number: Q4QBH1
Entry history
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)