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Q4QBD1

- Q4QBD1_LEIMA

UniProt

Q4QBD1 - Q4QBD1_LEIMA

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Protein

Aldose 1-epimerase

Gene

LMJF_23_0430

Organism
Leishmania major
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.UniRule annotation

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. aldose 1-epimerase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro

GO - Biological processi

  1. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimeraseUniRule annotation (EC:5.1.3.3UniRule annotation)
Alternative name(s):
Galactose mutarotaseUniRule annotation
Gene namesi
ORF Names:LMJF_23_0430Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000000542: Chromosome 23

PTM / Processingi

Proteomic databases

PRIDEiQ4QBD1.

Structurei

3D structure databases

ProteinModelPortaliQ4QBD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldose epimerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257432.
InParanoidiQ4QBD1.
KOiK01785.
OMAiLMRIRNT.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QBD1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADTQPVPAT VTSAHGAHAE AFGESFIVTL SSENLRVQLL SHGAALNSVQ
60 70 80 90 100
VRKPHPAASA TASASATAEQ DDEWLEVCLG YTNPEEALSA DAVIGHTIGR
110 120 130 140 150
YAGRIANGEF EIANTTYTLA KNFGPHNLHG GPVGFQHQEW KYLLSDGRDE
160 170 180 190 200
TGVAFHLVSP HMDQGFPGEL FVTATYSIIK SAPVPTLKYV LQASLSDNTP
210 220 230 240 250
VDMTVINLTN HAYWNLNGVP RPAAADAVAP LPRSIANHYL QLQSKYFAVT
260 270 280 290 300
DELSIPNGDM RPVEGTPHDY SALRCVAEGM EATKEEGRDG GGYDDPVALE
310 320 330 340 350
TWDSTLREAA LVYSPATKLR MQVCTTNPAI VVYTANHLPA DASGSKGQRF
360 370 380 390 400
QQHSAICLEC QYFPNSPNVR AFPSTVLKKG EAYNETTIHA FQFMNADITP

EEKLLRRQ
Length:408
Mass (Da):44,236
Last modified:July 19, 2005 - v1
Checksum:iE52AF10BD23E4D94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796419 Genomic DNA. Translation: CAJ04105.1.
RefSeqiXP_001683367.1. XM_001683315.1.

Genome annotation databases

EnsemblProtistsiLmjF.23.0430:mRNA; LmjF.23.0430:pep; LmjF.23.0430.
GeneIDi5652003.
KEGGilma:LMJF_23_0430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796419 Genomic DNA. Translation: CAJ04105.1 .
RefSeqi XP_001683367.1. XM_001683315.1.

3D structure databases

ProteinModelPortali Q4QBD1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q4QBD1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi LmjF.23.0430:mRNA ; LmjF.23.0430:pep ; LmjF.23.0430 .
GeneIDi 5652003.
KEGGi lma:LMJF_23_0430.

Phylogenomic databases

HOGENOMi HOG000257432.
InParanoidi Q4QBD1.
KOi K01785.
OMAi LMRIRNT.

Enzyme and pathway databases

UniPathwayi UPA00242 .

Family and domain databases

Gene3Di 2.70.98.10. 1 hit.
InterProi IPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view ]
Pfami PF01263. Aldose_epim. 1 hit.
[Graphical view ]
PIRSFi PIRSF005096. GALM. 1 hit.
SUPFAMi SSF74650. SSF74650. 1 hit.
PROSITEi PS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported.

Entry informationi

Entry nameiQ4QBD1_LEIMA
AccessioniPrimary (citable) accession number: Q4QBD1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3