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Q4QBD1

- Q4QBD1_LEIMA

UniProt

Q4QBD1 - Q4QBD1_LEIMA

Protein

Aldose 1-epimerase

Gene

LMJF_23_0430

Organism
Leishmania major
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.UniRule annotation

    Catalytic activityi

    Alpha-D-glucose = beta-D-glucose.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. aldose 1-epimerase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. hexose metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationImported

    Keywords - Biological processi

    Carbohydrate metabolismUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldose 1-epimeraseUniRule annotation (EC:5.1.3.3UniRule annotation)
    Alternative name(s):
    Galactose mutarotaseUniRule annotation
    Gene namesi
    ORF Names:LMJF_23_0430Imported
    OrganismiLeishmania majorImported
    Taxonomic identifieri5664 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
    ProteomesiUP000000542: Chromosome 23

    PTM / Processingi

    Proteomic databases

    PRIDEiQ4QBD1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4QBD1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldose epimerase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000257432.
    KOiK01785.
    OMAiLMRIRNT.

    Family and domain databases

    Gene3Di2.70.98.10. 1 hit.
    InterProiIPR018052. Ald1_epimerase_CS.
    IPR015443. Aldose_1-epimerase.
    IPR008183. Aldose_1/G6P_1-epimerase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    [Graphical view]
    PfamiPF01263. Aldose_epim. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005096. GALM. 1 hit.
    SUPFAMiSSF74650. SSF74650. 1 hit.
    PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4QBD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADTQPVPAT VTSAHGAHAE AFGESFIVTL SSENLRVQLL SHGAALNSVQ    50
    VRKPHPAASA TASASATAEQ DDEWLEVCLG YTNPEEALSA DAVIGHTIGR 100
    YAGRIANGEF EIANTTYTLA KNFGPHNLHG GPVGFQHQEW KYLLSDGRDE 150
    TGVAFHLVSP HMDQGFPGEL FVTATYSIIK SAPVPTLKYV LQASLSDNTP 200
    VDMTVINLTN HAYWNLNGVP RPAAADAVAP LPRSIANHYL QLQSKYFAVT 250
    DELSIPNGDM RPVEGTPHDY SALRCVAEGM EATKEEGRDG GGYDDPVALE 300
    TWDSTLREAA LVYSPATKLR MQVCTTNPAI VVYTANHLPA DASGSKGQRF 350
    QQHSAICLEC QYFPNSPNVR AFPSTVLKKG EAYNETTIHA FQFMNADITP 400
    EEKLLRRQ 408
    Length:408
    Mass (Da):44,236
    Last modified:July 19, 2005 - v1
    Checksum:iE52AF10BD23E4D94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR796419 Genomic DNA. Translation: CAJ04105.1.
    RefSeqiXP_001683367.1. XM_001683315.1.

    Genome annotation databases

    EnsemblProtistsiLmjF.23.0430:mRNA; LmjF.23.0430:pep; LmjF.23.0430.
    GeneIDi5652003.
    KEGGilma:LMJF_23_0430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR796419 Genomic DNA. Translation: CAJ04105.1 .
    RefSeqi XP_001683367.1. XM_001683315.1.

    3D structure databases

    ProteinModelPortali Q4QBD1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q4QBD1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi LmjF.23.0430:mRNA ; LmjF.23.0430:pep ; LmjF.23.0430 .
    GeneIDi 5652003.
    KEGGi lma:LMJF_23_0430.

    Phylogenomic databases

    HOGENOMi HOG000257432.
    KOi K01785.
    OMAi LMRIRNT.

    Enzyme and pathway databases

    UniPathwayi UPA00242 .

    Family and domain databases

    Gene3Di 2.70.98.10. 1 hit.
    InterProi IPR018052. Ald1_epimerase_CS.
    IPR015443. Aldose_1-epimerase.
    IPR008183. Aldose_1/G6P_1-epimerase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    [Graphical view ]
    Pfami PF01263. Aldose_epim. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005096. GALM. 1 hit.
    SUPFAMi SSF74650. SSF74650. 1 hit.
    PROSITEi PS00545. ALDOSE_1_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the kinetoplastid parasite, Leishmania major."
      Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
      , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
      Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MHOM/IL/81/FriedlinImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FriedlinImported.

    Entry informationi

    Entry nameiQ4QBD1_LEIMA
    AccessioniPrimary (citable) accession number: Q4QBD1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3