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Q4QBD1

- Q4QBD1_LEIMA

UniProt

Q4QBD1 - Q4QBD1_LEIMA

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Protein
Aldose 1-epimerase
Gene
LMJF_23_0430
Organism
Leishmania major
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.UniRule annotation

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. aldose 1-epimerase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimeraseUniRule annotation (EC:5.1.3.3UniRule annotation)
Alternative name(s):
Galactose mutarotase
Gene namesi
ORF Names:LMJF_23_0430Imported
OrganismiLeishmania major
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000000542: Chromosome 23

PTM / Processingi

Proteomic databases

PRIDEiQ4QBD1.

Structurei

3D structure databases

ProteinModelPortaliQ4QBD1.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldose epimerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257432.
KOiK01785.
OMAiLMRIRNT.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QBD1-1 [UniParc]FASTAAdd to Basket

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MADTQPVPAT VTSAHGAHAE AFGESFIVTL SSENLRVQLL SHGAALNSVQ    50
VRKPHPAASA TASASATAEQ DDEWLEVCLG YTNPEEALSA DAVIGHTIGR 100
YAGRIANGEF EIANTTYTLA KNFGPHNLHG GPVGFQHQEW KYLLSDGRDE 150
TGVAFHLVSP HMDQGFPGEL FVTATYSIIK SAPVPTLKYV LQASLSDNTP 200
VDMTVINLTN HAYWNLNGVP RPAAADAVAP LPRSIANHYL QLQSKYFAVT 250
DELSIPNGDM RPVEGTPHDY SALRCVAEGM EATKEEGRDG GGYDDPVALE 300
TWDSTLREAA LVYSPATKLR MQVCTTNPAI VVYTANHLPA DASGSKGQRF 350
QQHSAICLEC QYFPNSPNVR AFPSTVLKKG EAYNETTIHA FQFMNADITP 400
EEKLLRRQ 408
Length:408
Mass (Da):44,236
Last modified:July 19, 2005 - v1
Checksum:iE52AF10BD23E4D94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796419 Genomic DNA. Translation: CAJ04105.1.
RefSeqiXP_001683367.1. XM_001683315.1.

Genome annotation databases

EnsemblProtistsiLmjF.23.0430:mRNA; LmjF.23.0430:pep; LmjF.23.0430.
GeneIDi5652003.
KEGGilma:LMJF_23_0430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796419 Genomic DNA. Translation: CAJ04105.1 .
RefSeqi XP_001683367.1. XM_001683315.1.

3D structure databases

ProteinModelPortali Q4QBD1.
ModBasei Search...

Proteomic databases

PRIDEi Q4QBD1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi LmjF.23.0430:mRNA ; LmjF.23.0430:pep ; LmjF.23.0430 .
GeneIDi 5652003.
KEGGi lma:LMJF_23_0430.

Phylogenomic databases

HOGENOMi HOG000257432.
KOi K01785.
OMAi LMRIRNT.

Enzyme and pathway databases

UniPathwayi UPA00242 .

Family and domain databases

Gene3Di 2.70.98.10. 1 hit.
InterProi IPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view ]
Pfami PF01263. Aldose_epim. 1 hit.
[Graphical view ]
PIRSFi PIRSF005096. GALM. 1 hit.
SUPFAMi SSF74650. SSF74650. 1 hit.
PROSITEi PS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/Friedlin.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported.

Entry informationi

Entry nameiQ4QBD1_LEIMA
AccessioniPrimary (citable) accession number: Q4QBD1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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