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Q4QBD1 (Q4QBD1_LEIMA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Aldose 1-epimerase PIRNR PIRNR005096

EC=5.1.3.3 PIRNR PIRNR005096
Alternative name(s):
Galactose mutarotase PIRNR PIRNR005096
Gene names
ORF Names:LMJF_23_0430 EMBL CAJ04105.1
OrganismLeishmania major [Reference proteome]
Taxonomic identifier5664 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity. PIRNR PIRNR005096

Catalytic activity

Alpha-D-glucose = beta-D-glucose. PIRNR PIRNR005096

Pathway

Carbohydrate metabolism; hexose metabolism. PIRNR PIRNR005096

Sequence similarities

Belongs to the aldose epimerase family. PIRNR PIRNR005096

Ontologies

Keywords
   Biological processCarbohydrate metabolism PIRNR PIRNR005096
   Molecular functionIsomerase PIRNR PIRNR005096 EMBL CAJ04105.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhexose metabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionaldose 1-epimerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q4QBD1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: E52AF10BD23E4D94

FASTA40844,236
        10         20         30         40         50         60 
MADTQPVPAT VTSAHGAHAE AFGESFIVTL SSENLRVQLL SHGAALNSVQ VRKPHPAASA 

        70         80         90        100        110        120 
TASASATAEQ DDEWLEVCLG YTNPEEALSA DAVIGHTIGR YAGRIANGEF EIANTTYTLA 

       130        140        150        160        170        180 
KNFGPHNLHG GPVGFQHQEW KYLLSDGRDE TGVAFHLVSP HMDQGFPGEL FVTATYSIIK 

       190        200        210        220        230        240 
SAPVPTLKYV LQASLSDNTP VDMTVINLTN HAYWNLNGVP RPAAADAVAP LPRSIANHYL 

       250        260        270        280        290        300 
QLQSKYFAVT DELSIPNGDM RPVEGTPHDY SALRCVAEGM EATKEEGRDG GGYDDPVALE 

       310        320        330        340        350        360 
TWDSTLREAA LVYSPATKLR MQVCTTNPAI VVYTANHLPA DASGSKGQRF QQHSAICLEC 

       370        380        390        400 
QYFPNSPNVR AFPSTVLKKG EAYNETTIHA FQFMNADITP EEKLLRRQ 

« Hide

References

[1]"The genome of the kinetoplastid parasite, Leishmania major."
Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G. expand/collapse author list , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MHOM/IL/81/Friedlin.
[2]"Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania."
Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A., Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C.
Genome Res. 21:2129-2142(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Friedlin EMBL CAJ04105.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR796419 Genomic DNA. Translation: CAJ04105.1.
RefSeqXP_001683367.1. XM_001683315.1.

3D structure databases

ProteinModelPortalQ4QBD1.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ4QBD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsLmjF.23.0430:mRNA; LmjF.23.0430:pep; LmjF.23.0430.
GeneID5652003.
KEGGlma:LMJF_23_0430.

Phylogenomic databases

HOGENOMHOG000257432.
KOK01785.
OMALMRIRNT.

Enzyme and pathway databases

UniPathwayUPA00242.

Family and domain databases

Gene3D2.70.98.10. 1 hit.
InterProIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFPIRSF005096. GALM. 1 hit.
SUPFAMSSF74650. SSF74650. 1 hit.
PROSITEPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4QBD1_LEIMA
AccessionPrimary (citable) accession number: Q4QBD1
Entry history
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)