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Q4Q7X6 (Q4Q7X6_LEIMA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase RuleBase RU003405
EC=1.1.1.37 RuleBase RU003405
Gene names
Name:cMDH EMBL CAJ05744.1
ORF Names:LMJF_28_2860 EMBL CAJ05744.1
OrganismLeishmania major [Reference proteome]
Taxonomic identifier5664 [NCBI]
Taxonomic lineageEukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmaniinae › Leishmania ›

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. RuleBase RU003405

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family.

Sequences

Sequence LengthMass (Da)Tools
Q4Q7X6 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 0915AD2FF0BC7B67

FASTA32434,155
        10         20         30         40         50         60 
MSAVKVAVTG AAGQIGYALV PLIARGALLG PTTPVELRLL DIEPALKALA GVEAELEDCA 

        70         80         90        100        110        120 
FPLLDKVVVT ADPRVAFDGV AIAIMCGAFP RKAGMERKDL LEMNARIFKE QGEAIAAVAA 

       130        140        150        160        170        180 
SDCRVVVVGN PANTNALILL KSAQGKLNPR HVTAMTRLDH NRALSLLARK AGVPVSQVRN 

       190        200        210        220        230        240 
VIIWGNHSST QVPDTDSAVI GTTPAREAIK DDALDDDFVQ VVRGRGAEII QLRGLSSAMS 

       250        260        270        280        290        300 
AAKAAVDHVH DWIHGTPEGV YVSMGVYSDE NPYGVPSGLI FSFPCTCHAG EWTVVSGKLN 

       310        320 
GDLGKQRLAS TIAELQEERA QAGL

« Hide

References

« Hide 'large scale' references
[1]"The genome of the kinetoplastid parasite, Leishmania major."
Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G. expand/collapse author list , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MHOM/IL/81/Friedlin.
[2]"Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin."
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Abendroth J., Sankaran B., Staker B.L., Stewart L.J., Myler P.
Submitted (SEP-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS).
[3]"Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin in complex with NAD."
SSGCID, Abendroth J., Edwards T.E., Myler P.
Submitted (NOV-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FR796424 Genomic DNA. Translation: CAJ05744.1.
RefSeqXP_001684572.1. XM_001684520.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4H7PX-ray1.30A/B1-324[»]
4I1IX-ray1.50A/B1-324[»]
ProteinModelPortalQ4Q7X6.
SMRQ4Q7X6. Positions 3-320.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsLmjF.28.2860:mRNA; LmjF.28.2860:pep; LmjF.28.2860.
GeneID5653501.
KEGGlma:LMJF_28_2860.

Phylogenomic databases

HOGENOMHOG000220953.
KOK00025.
OMANCLIASK.
ProtClustDBCLSZ2437838.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23382. PTHR23382. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4Q7X6_LEIMA
AccessionPrimary (citable) accession number: Q4Q7X6
Entry history
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info