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Protein

Adenylate kinase isoenzyme 6 homolog

Gene

LMJF_30_1890

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431AMPUniRule annotation
Metal bindingi78 – 781ManganeseCombined sources
Metal bindingi79 – 791Manganese; via carbonyl oxygenCombined sources
Metal bindingi82 – 821Manganese; via tele nitrogenCombined sources
Binding sitei87 – 871ATPUniRule annotation
Binding sitei113 – 1131ADPCombined sources
Binding sitei113 – 1131ATPUniRule annotation
Binding sitei117 – 1171ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 216ADPCombined sources
Nucleotide bindingi16 – 216ATPUniRule annotation
Nucleotide bindingi156 – 1572ADPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, ManganeseCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6 homologUniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Dual activity adenylate kinase/ATPaseUniRule annotation
Gene namesi
ORF Names:LMJF_30_1890Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 30

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.30.1890.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y63X-ray1.70A1-180[»]
ProteinModelPortaliQ4Q7A6.
SMRiQ4Q7A6. Positions 2-175.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4Q7A6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 6327NMPbindUniRule annotationAdd
BLAST
Regioni116 – 12611LIDUniRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili150 – 17728Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
HOGENOMiHOG000224472.
InParanoidiQ4Q7A6.
KOiK18532.
OMAiDNVQCEI.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4Q7A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPKGINIL ITGTPGTGKT SMAEMIAAEL DGFQHLEVGK LVKENHFYTE
60 70 80 90 100
YDTELDTHII EEKDEDRLLD FMEPIMVSRG NHVVDYHSSE LFPERWFHMV
110 120 130 140 150
VVLHTSTEVL FERLTKRQYS EAKRAENMEA EIQCICEEEA RDAYEDDIVL
160 170 180
VRENDTLEQM AATVEEIRER VEVLKVERGL
Length:180
Mass (Da):20,934
Last modified:July 19, 2005 - v1
Checksum:i8FEE0A348E1B1661
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796426 Genomic DNA. Translation: CAJ06352.1.
RefSeqiXP_001684792.1. XM_001684740.1.

Genome annotation databases

EnsemblProtistsiLmjF.30.1890:mRNA; LmjF.30.1890:pep; LmjF.30.1890.
GeneIDi5653731.
KEGGilma:LMJF_30_1890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796426 Genomic DNA. Translation: CAJ06352.1.
RefSeqiXP_001684792.1. XM_001684740.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y63X-ray1.70A1-180[»]
ProteinModelPortaliQ4Q7A6.
SMRiQ4Q7A6. Positions 2-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.30.1890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.30.1890:mRNA; LmjF.30.1890:pep; LmjF.30.1890.
GeneIDi5653731.
KEGGilma:LMJF_30_1890.

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
HOGENOMiHOG000224472.
InParanoidiQ4Q7A6.
KOiK18532.
OMAiDNVQCEI.

Miscellaneous databases

EvolutionaryTraceiQ4Q7A6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Crystal structural analysis of a probable kinase from Leishmania major Friedlin."
    Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
    Robien M.A., Hol W.G.J.
    Submitted (DEC-2004) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH ADP AND MANGANESE.
  2. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.

Entry informationi

Entry nameiQ4Q7A6_LEIMA
AccessioniPrimary (citable) accession number: Q4Q7A6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.