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Protein

Adenylate kinase isoenzyme 6 homolog

Gene

LMJF_30_1890

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43AMPUniRule annotation1
Metal bindingi78ManganeseCombined sources1
Metal bindingi79Manganese; via carbonyl oxygenCombined sources1
Metal bindingi82Manganese; via tele nitrogenCombined sources1
Binding sitei87ATPUniRule annotation1
Binding sitei113ADPCombined sources1
Binding sitei113ATPUniRule annotation1
Binding sitei117ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 21ADPCombined sources6
Nucleotide bindingi16 – 21ATPUniRule annotation6
Nucleotide bindingi156 – 157ADPCombined sources2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, ManganeseCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6 homologUniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Dual activity adenylate kinase/ATPaseUniRule annotation
Gene namesi
ORF Names:LMJF_30_1890Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 30

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.30.1890.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y63X-ray1.70A1-180[»]
ProteinModelPortaliQ4Q7A6.
SMRiQ4Q7A6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4Q7A6.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 63NMPbindUniRule annotationAdd BLAST27
Regioni116 – 126LIDUniRule annotationAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili150 – 177Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
HOGENOMiHOG000224472.
InParanoidiQ4Q7A6.
KOiK18532.
OMAiQSWIVDE.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4Q7A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPKGINIL ITGTPGTGKT SMAEMIAAEL DGFQHLEVGK LVKENHFYTE
60 70 80 90 100
YDTELDTHII EEKDEDRLLD FMEPIMVSRG NHVVDYHSSE LFPERWFHMV
110 120 130 140 150
VVLHTSTEVL FERLTKRQYS EAKRAENMEA EIQCICEEEA RDAYEDDIVL
160 170 180
VRENDTLEQM AATVEEIRER VEVLKVERGL
Length:180
Mass (Da):20,934
Last modified:July 19, 2005 - v1
Checksum:i8FEE0A348E1B1661
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796426 Genomic DNA. Translation: CAJ06352.1.
RefSeqiXP_001684792.1. XM_001684740.1.

Genome annotation databases

EnsemblProtistsiLmjF.30.1890:mRNA; LmjF.30.1890:pep; LmjF.30.1890.
GeneDBiLmjF.30.1890:pep.
GeneIDi5653731.
KEGGilma:LMJF_30_1890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796426 Genomic DNA. Translation: CAJ06352.1.
RefSeqiXP_001684792.1. XM_001684740.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y63X-ray1.70A1-180[»]
ProteinModelPortaliQ4Q7A6.
SMRiQ4Q7A6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.30.1890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.30.1890:mRNA; LmjF.30.1890:pep; LmjF.30.1890.
GeneDBiLmjF.30.1890:pep.
GeneIDi5653731.
KEGGilma:LMJF_30_1890.

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
HOGENOMiHOG000224472.
InParanoidiQ4Q7A6.
KOiK18532.
OMAiQSWIVDE.

Miscellaneous databases

EvolutionaryTraceiQ4Q7A6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ4Q7A6_LEIMA
AccessioniPrimary (citable) accession number: Q4Q7A6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.