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Q4Q6U5 (Q4Q6U5_LEIMA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617

EC=6.5.1.1 RuleBase RU000617
Gene names
ORF Names:LMJF_30_3440 EMBL CAJ06835.1
OrganismLeishmania major [Reference proteome]
Taxonomic identifier5664 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length681 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Sequences

Sequence LengthMass (Da)Tools
Q4Q6U5 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 2075DDC73808D120

FASTA68175,433
        10         20         30         40         50         60 
MALVADVPPP TATSMAKLFQ ESSFDPVTTF EAVWLPPRVP AAPPTAGASE PVPFAAVVDV 

        70         80         90        100        110        120 
LADISATGSR LECLKQLTFL LLAVIERCPE DLVPVMYLVI NKHAPQHEGV ELGIGDAVLV 

       130        140        150        160        170        180 
KAVAECCGMT ETRAKEEYRQ SGDLAEIAQM HKQKQGTLMK PKPLSARSVF KTYKEIAMMS 

       190        200        210        220        230        240 
GRDVMRRRSD LIKGLLRDAQ GPEVNLIVRG LQQKMRIGLA EPSALAAVGY AFALHFLGGA 

       250        260        270        280        290        300 
QMHKMDEVQL QTLLNTGADS LARIFYEVPS LDVVLSAVLA NGFMTLVPGS SIAKQYAKDL 

       310        320        330        340        350        360 
SIRPGLPVKP QLAYPTSSIT VILDRLQGKK FTSEYKYDGE RAQIHYDKDK GFHIFSRNSE 

       370        380        390        400        410        420 
THTGKYPDVI SMLPKVFDPV EVQSFILDSE VVAVHSETGA LQAFQVLQHR GRKNIAEEDV 

       430        440        450        460        470        480 
SIPVCVFVFD ILYFNGEPQL NKTLQQRREL LWRCIHPLPA KLSFATHLDS EKVEDVQTFL 

       490        500        510        520        530        540 
ERSIADGCEG LMVKTLEEEA NYTPAKRSHY WLKLKKDYMD GVTDTLDLVP IAAFYGKGKR 

       550        560        570        580        590        600 
TGVFGGFLLA CYDPKADEYQ SICKIGTGFQ DEELEKLTQS LKPFVVDEKP RYYRAGGEEP 

       610        620        630        640        650        660 
DVWLTEAQVW EVKAADLSVS PVHQAAVGLV DPDKGIALRF PRYLRQREDK KPADATNARQ 

       670        680 
VADMYKAQSL AAEHDANGDA E 

« Hide

References

[1]"The genome of the kinetoplastid parasite, Leishmania major."
Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G. expand/collapse author list , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MHOM/IL/81/Friedlin.
[2]"Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania."
Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A., Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C.
Genome Res. 21:2129-2142(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Friedlin EMBL CAJ06835.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR796426 Genomic DNA. Translation: CAJ06835.1.
RefSeqXP_001684953.1. XM_001684901.1.

3D structure databases

ProteinModelPortalQ4Q6U5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsLmjF.30.3440:mRNA; LmjF.30.3440:pep; LmjF.30.3440.
GeneID5653894.
KEGGlma:LMJF_30_3440.

Phylogenomic databases

HOGENOMHOG000036006.
KOK10747.
OMADKGGPSE.
ProtClustDBCLSZ2441791.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4Q6U5_LEIMA
AccessionPrimary (citable) accession number: Q4Q6U5
Entry history
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)