Q4Q6U5 (Q4Q6U5_LEIMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

ORF Names:

LMJF_30_3440 EMBL CAJ06835.1

Organism

Leishmania major [Reference proteome]

Taxonomic identifier

5664 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmaniinae › Leishmania › Leishmania › Leishmania major species complex

Protein attributes

Sequence length	681 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617 EMBL CAJ06835.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW lagging strand elongation Inferred from Biological aspect of Ancestor. Source: RefGenome nucleotide-excision repair Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	chromosome Inferred from Biological aspect of Ancestor. Source: RefGenome mitochondrion Inferred from Biological aspect of Ancestor. Source: RefGenome nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4Q6U5 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 2075DDC73808D120	FASTA	681	75,433
	10 20 30 40 50 60 MALVADVPPP TATSMAKLFQ ESSFDPVTTF EAVWLPPRVP AAPPTAGASE PVPFAAVVDV 70 80 90 100 110 120 LADISATGSR LECLKQLTFL LLAVIERCPE DLVPVMYLVI NKHAPQHEGV ELGIGDAVLV 130 140 150 160 170 180 KAVAECCGMT ETRAKEEYRQ SGDLAEIAQM HKQKQGTLMK PKPLSARSVF KTYKEIAMMS 190 200 210 220 230 240 GRDVMRRRSD LIKGLLRDAQ GPEVNLIVRG LQQKMRIGLA EPSALAAVGY AFALHFLGGA 250 260 270 280 290 300 QMHKMDEVQL QTLLNTGADS LARIFYEVPS LDVVLSAVLA NGFMTLVPGS SIAKQYAKDL 310 320 330 340 350 360 SIRPGLPVKP QLAYPTSSIT VILDRLQGKK FTSEYKYDGE RAQIHYDKDK GFHIFSRNSE 370 380 390 400 410 420 THTGKYPDVI SMLPKVFDPV EVQSFILDSE VVAVHSETGA LQAFQVLQHR GRKNIAEEDV 430 440 450 460 470 480 SIPVCVFVFD ILYFNGEPQL NKTLQQRREL LWRCIHPLPA KLSFATHLDS EKVEDVQTFL 490 500 510 520 530 540 ERSIADGCEG LMVKTLEEEA NYTPAKRSHY WLKLKKDYMD GVTDTLDLVP IAAFYGKGKR 550 560 570 580 590 600 TGVFGGFLLA CYDPKADEYQ SICKIGTGFQ DEELEKLTQS LKPFVVDEKP RYYRAGGEEP 610 620 630 640 650 660 DVWLTEAQVW EVKAADLSVS PVHQAAVGLV DPDKGIALRF PRYLRQREDK KPADATNARQ 670 680 VADMYKAQSL AAEHDANGDA E

References

[1]

"The genome of the kinetoplastid parasite, Leishmania major." Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G. , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J. Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MHOM/IL/81/Friedlin.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FR796426 Genomic DNA. Translation: CAJ06835.1.
RefSeq	XP_001684953.1. XM_001684901.1.
3D structure databases
ProteinModelPortal	Q4Q6U5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	LmjF.30.3440:mRNA; LmjF.30.3440:pep; LmjF.30.3440.
GeneID	5653894.
KEGG	lma:LMJF_30_3440.
Phylogenomic databases
HOGENOM	HOG000036006.
KO	K10747.
OMA	AQVACLY.
ProtClustDB	CLSZ2441791.
Family and domain databases
Gene3D	1.10.3260.10. 1 hit. 2.40.50.140. 1 hit.
InterPro	IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4Q6U5_LEIMA

Accession

Primary (citable) accession number: Q4Q6U5

Entry history

Integrated into UniProtKB/TrEMBL:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)