SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4Q6U5

- Q4Q6U5_LEIMA

UniProt

Q4Q6U5 - Q4Q6U5_LEIMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
DNA ligase
Gene
LMJF_30_3440
Organism
Leishmania major
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome

GO - Biological processi

  1. DNA ligation Source: RefGenome
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. lagging strand elongation Source: RefGenome
  5. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:LMJF_30_3440Imported
OrganismiLeishmania major
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000000542: Chromosome 30

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
  2. mitochondrion Source: RefGenome
  3. nucleus Source: RefGenome
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ4Q6U5.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006.
KOiK10747.
OMAiLDPSGYN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4Q6U5-1 [UniParc]FASTAAdd to Basket

« Hide

MALVADVPPP TATSMAKLFQ ESSFDPVTTF EAVWLPPRVP AAPPTAGASE    50
PVPFAAVVDV LADISATGSR LECLKQLTFL LLAVIERCPE DLVPVMYLVI 100
NKHAPQHEGV ELGIGDAVLV KAVAECCGMT ETRAKEEYRQ SGDLAEIAQM 150
HKQKQGTLMK PKPLSARSVF KTYKEIAMMS GRDVMRRRSD LIKGLLRDAQ 200
GPEVNLIVRG LQQKMRIGLA EPSALAAVGY AFALHFLGGA QMHKMDEVQL 250
QTLLNTGADS LARIFYEVPS LDVVLSAVLA NGFMTLVPGS SIAKQYAKDL 300
SIRPGLPVKP QLAYPTSSIT VILDRLQGKK FTSEYKYDGE RAQIHYDKDK 350
GFHIFSRNSE THTGKYPDVI SMLPKVFDPV EVQSFILDSE VVAVHSETGA 400
LQAFQVLQHR GRKNIAEEDV SIPVCVFVFD ILYFNGEPQL NKTLQQRREL 450
LWRCIHPLPA KLSFATHLDS EKVEDVQTFL ERSIADGCEG LMVKTLEEEA 500
NYTPAKRSHY WLKLKKDYMD GVTDTLDLVP IAAFYGKGKR TGVFGGFLLA 550
CYDPKADEYQ SICKIGTGFQ DEELEKLTQS LKPFVVDEKP RYYRAGGEEP 600
DVWLTEAQVW EVKAADLSVS PVHQAAVGLV DPDKGIALRF PRYLRQREDK 650
KPADATNARQ VADMYKAQSL AAEHDANGDA E 681
Length:681
Mass (Da):75,433
Last modified:July 19, 2005 - v1
Checksum:i2075DDC73808D120
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796426 Genomic DNA. Translation: CAJ06835.1.
RefSeqiXP_001684953.1. XM_001684901.1.

Genome annotation databases

EnsemblProtistsiLmjF.30.3440:mRNA; LmjF.30.3440:pep; LmjF.30.3440.
GeneIDi5653894.
KEGGilma:LMJF_30_3440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796426 Genomic DNA. Translation: CAJ06835.1 .
RefSeqi XP_001684953.1. XM_001684901.1.

3D structure databases

ProteinModelPortali Q4Q6U5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi LmjF.30.3440:mRNA ; LmjF.30.3440:pep ; LmjF.30.3440 .
GeneIDi 5653894.
KEGGi lma:LMJF_30_3440.

Phylogenomic databases

HOGENOMi HOG000036006.
KOi K10747.
OMAi LDPSGYN.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/Friedlin.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported.

Entry informationi

Entry nameiQ4Q6U5_LEIMA
AccessioniPrimary (citable) accession number: Q4Q6U5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi