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Protein

DNA ligase

Gene

LMJF_30_3440

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotationImported)
Gene namesi
ORF Names:LMJF_30_3440Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000000542 Componenti: Chromosome 30

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.30.3440.

Structurei

3D structure databases

ProteinModelPortaliQ4Q6U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiQ4Q6U5.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4Q6U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVADVPPP TATSMAKLFQ ESSFDPVTTF EAVWLPPRVP AAPPTAGASE
60 70 80 90 100
PVPFAAVVDV LADISATGSR LECLKQLTFL LLAVIERCPE DLVPVMYLVI
110 120 130 140 150
NKHAPQHEGV ELGIGDAVLV KAVAECCGMT ETRAKEEYRQ SGDLAEIAQM
160 170 180 190 200
HKQKQGTLMK PKPLSARSVF KTYKEIAMMS GRDVMRRRSD LIKGLLRDAQ
210 220 230 240 250
GPEVNLIVRG LQQKMRIGLA EPSALAAVGY AFALHFLGGA QMHKMDEVQL
260 270 280 290 300
QTLLNTGADS LARIFYEVPS LDVVLSAVLA NGFMTLVPGS SIAKQYAKDL
310 320 330 340 350
SIRPGLPVKP QLAYPTSSIT VILDRLQGKK FTSEYKYDGE RAQIHYDKDK
360 370 380 390 400
GFHIFSRNSE THTGKYPDVI SMLPKVFDPV EVQSFILDSE VVAVHSETGA
410 420 430 440 450
LQAFQVLQHR GRKNIAEEDV SIPVCVFVFD ILYFNGEPQL NKTLQQRREL
460 470 480 490 500
LWRCIHPLPA KLSFATHLDS EKVEDVQTFL ERSIADGCEG LMVKTLEEEA
510 520 530 540 550
NYTPAKRSHY WLKLKKDYMD GVTDTLDLVP IAAFYGKGKR TGVFGGFLLA
560 570 580 590 600
CYDPKADEYQ SICKIGTGFQ DEELEKLTQS LKPFVVDEKP RYYRAGGEEP
610 620 630 640 650
DVWLTEAQVW EVKAADLSVS PVHQAAVGLV DPDKGIALRF PRYLRQREDK
660 670 680
KPADATNARQ VADMYKAQSL AAEHDANGDA E
Length:681
Mass (Da):75,433
Last modified:July 19, 2005 - v1
Checksum:i2075DDC73808D120
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796426 Genomic DNA. Translation: CAJ06835.1.
RefSeqiXP_001684953.1. XM_001684901.1.

Genome annotation databases

EnsemblProtistsiLmjF.30.3440:mRNA; LmjF.30.3440:pep; LmjF.30.3440.
GeneIDi5653894.
KEGGilma:LMJF_30_3440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796426 Genomic DNA. Translation: CAJ06835.1.
RefSeqiXP_001684953.1. XM_001684901.1.

3D structure databases

ProteinModelPortaliQ4Q6U5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.30.3440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.30.3440:mRNA; LmjF.30.3440:pep; LmjF.30.3440.
GeneIDi5653894.
KEGGilma:LMJF_30_3440.

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiQ4Q6U5.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported.

Entry informationi

Entry nameiQ4Q6U5_LEIMA
AccessioniPrimary (citable) accession number: Q4Q6U5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 22, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.