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Protein

DNA ligase

Gene

LMJF_30_3440

Organism
Leishmania major
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:LMJF_30_3440Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 30

Organism-specific databases

EuPathDBiTriTrypDB:LmjF.30.3440

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.30.3440

Structurei

3D structure databases

ProteinModelPortaliQ4Q6U5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini417 – 553DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
HOGENOMiHOG000036006
InParanoidiQ4Q6U5
KOiK10747
OMAiWIKYKRD

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q4Q6U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVADVPPP TATSMAKLFQ ESSFDPVTTF EAVWLPPRVP AAPPTAGASE
60 70 80 90 100
PVPFAAVVDV LADISATGSR LECLKQLTFL LLAVIERCPE DLVPVMYLVI
110 120 130 140 150
NKHAPQHEGV ELGIGDAVLV KAVAECCGMT ETRAKEEYRQ SGDLAEIAQM
160 170 180 190 200
HKQKQGTLMK PKPLSARSVF KTYKEIAMMS GRDVMRRRSD LIKGLLRDAQ
210 220 230 240 250
GPEVNLIVRG LQQKMRIGLA EPSALAAVGY AFALHFLGGA QMHKMDEVQL
260 270 280 290 300
QTLLNTGADS LARIFYEVPS LDVVLSAVLA NGFMTLVPGS SIAKQYAKDL
310 320 330 340 350
SIRPGLPVKP QLAYPTSSIT VILDRLQGKK FTSEYKYDGE RAQIHYDKDK
360 370 380 390 400
GFHIFSRNSE THTGKYPDVI SMLPKVFDPV EVQSFILDSE VVAVHSETGA
410 420 430 440 450
LQAFQVLQHR GRKNIAEEDV SIPVCVFVFD ILYFNGEPQL NKTLQQRREL
460 470 480 490 500
LWRCIHPLPA KLSFATHLDS EKVEDVQTFL ERSIADGCEG LMVKTLEEEA
510 520 530 540 550
NYTPAKRSHY WLKLKKDYMD GVTDTLDLVP IAAFYGKGKR TGVFGGFLLA
560 570 580 590 600
CYDPKADEYQ SICKIGTGFQ DEELEKLTQS LKPFVVDEKP RYYRAGGEEP
610 620 630 640 650
DVWLTEAQVW EVKAADLSVS PVHQAAVGLV DPDKGIALRF PRYLRQREDK
660 670 680
KPADATNARQ VADMYKAQSL AAEHDANGDA E
Length:681
Mass (Da):75,433
Last modified:July 19, 2005 - v1
Checksum:i2075DDC73808D120
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796426 Genomic DNA Translation: CAJ06835.1
RefSeqiXP_001684953.1, XM_001684901.1

Genome annotation databases

EnsemblProtistsiLmjF.30.3440:mRNA; LmjF.30.3440:pep; LmjF.30.3440
GeneDBiLmjF.30.3440:pep
GeneIDi5653894
KEGGilma:LMJF_30_3440

Similar proteinsi

Entry informationi

Entry nameiQ4Q6U5_LEIMA
AccessioniPrimary (citable) accession number: Q4Q6U5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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