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Protein

Mevalonate kinase

Gene

LMJF_31_0560

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.UniRule annotation

Pathwayi: isopentenyl diphosphate biosynthesis via mevalonate pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Mevalonate kinase (LMJF_31_0560)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate, the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway and in Isoprenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesisUniRule annotation, Sterol metabolism

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.36. 2950.
UniPathwayiUPA00057; UER00098.

Names & Taxonomyi

Protein namesi
Recommended name:
Mevalonate kinaseUniRule annotation (EC:2.7.1.36UniRule annotation)
Short name:
MKUniRule annotation
Gene namesi
ORF Names:LMJF_31_0560Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 31

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.31.0560.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HFSX-ray1.75A/B1-329[»]
2HFUX-ray2.00A/B1-329[»]
ProteinModelPortaliQ4Q6K7.
SMRiQ4Q6K7. Positions 1-326.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4Q6K7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 16359GHMP_kinases_NInterPro annotationAdd
BLAST
Domaini230 – 31182GHMP_kinases_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1511. Eukaryota.
COG1577. LUCA.
HOGENOMiHOG000080810.
InParanoidiQ4Q6K7.
KOiK00869.
OMAiYECKMAN.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006205. Mev_gal_kin.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSiPR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00549. mevalon_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4Q6K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPVKSKTT GKNIGYGKVI LFGEHFVVHG AEAIVAGISE YTECRLEINP
60 70 80 90 100
GVPGLQVDDQ RPAIPGYIAQ KRDEQIKAHQ LVLDHLKVDL SGDGLKMFIG
110 120 130 140 150
GPLVPSSGIG ASASDVVAFS RALSELYQLN LTDEEVNLSA FVGEGGYHGT
160 170 180 190 200
PSGADNTAAT YGGLILYRRQ NGKSVFKPIA FQQRLYLVVV GTGINASTAK
210 220 230 240 250
VVNDVHKMKQ QQPVQFKRLY DNYTHIVSQA REALQKGDLQ RLGQLMNANH
260 270 280 290 300
DLCRQIDVSC RELESIVQTC RTYGALGAKL SGTGRGGIAV ALAASSDQRD
310 320
AIVKGLKAKC PEAKFIWRYT VQPSAASNL
Length:329
Mass (Da):35,485
Last modified:July 19, 2005 - v1
Checksum:i844F8F76C992D0CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796427 Genomic DNA. Translation: CAJ08243.1.
RefSeqiXP_001685041.1. XM_001684989.1.

Genome annotation databases

EnsemblProtistsiLmjF.31.0560:mRNA; LmjF.31.0560:pep; LmjF.31.0560.
GeneIDi5653982.
KEGGilma:LMJF_31_0560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796427 Genomic DNA. Translation: CAJ08243.1.
RefSeqiXP_001685041.1. XM_001684989.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HFSX-ray1.75A/B1-329[»]
2HFUX-ray2.00A/B1-329[»]
ProteinModelPortaliQ4Q6K7.
SMRiQ4Q6K7. Positions 1-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.31.0560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.31.0560:mRNA; LmjF.31.0560:pep; LmjF.31.0560.
GeneIDi5653982.
KEGGilma:LMJF_31_0560.

Phylogenomic databases

eggNOGiKOG1511. Eukaryota.
COG1577. LUCA.
HOGENOMiHOG000080810.
InParanoidiQ4Q6K7.
KOiK00869.
OMAiYECKMAN.

Enzyme and pathway databases

UniPathwayiUPA00057; UER00098.
BRENDAi2.7.1.36. 2950.

Miscellaneous databases

EvolutionaryTraceiQ4Q6K7.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006205. Mev_gal_kin.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSiPR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00549. mevalon_kin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ4Q6K7_LEIMA
AccessioniPrimary (citable) accession number: Q4Q6K7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.