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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

CYP4

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
Gene namesi
Name:CYP4Imported
ORF Names:LMJF_33_1630Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 33

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.33.1630.

Structurei

3D structure databases

ProteinModelPortaliQ4Q424.
SMRiQ4Q424. Positions 46-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 216167PPIase cyclophilin-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation
Contains 1 PPIase cyclophilin-type domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
InParanoidiQ4Q424.
KOiK01802.
OMAiVIPAFMC.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4Q424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSEALVISY FLRSCSLKVS LPPKMLRRTF LSAERRIPFY PINSNNPIVF
60 70 80 90 100
FDISIGSQPA GRVEMELFKD VVPKTAENFR ALCTGEKGVG RSGKPLWFKG
110 120 130 140 150
SRFHRVIPQF MCQGGDFTAG NGTGGESIYG HKFPDESFAG RAGRHFGPGT
160 170 180 190 200
LSMANAGPNT NGSQFFICTA PTDWLDGKHV VFGQVTKGYD VIMKVETQGS
210 220
QSGATRQPIT VTDCGEIKQE
Length:220
Mass (Da):24,091
Last modified:July 19, 2005 - v1
Checksum:i5F18D5ED77BDC35F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796429 Genomic DNA. Translation: CAJ06422.1.
RefSeqiXP_001685924.1. XM_001685872.1.

Genome annotation databases

EnsemblProtistsiLmjF.33.1630:mRNA; LmjF.33.1630:pep; LmjF.33.1630.
GeneIDi5654586.
KEGGilma:LMJF_33_1630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796429 Genomic DNA. Translation: CAJ06422.1.
RefSeqiXP_001685924.1. XM_001685872.1.

3D structure databases

ProteinModelPortaliQ4Q424.
SMRiQ4Q424. Positions 46-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.33.1630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.33.1630:mRNA; LmjF.33.1630:pep; LmjF.33.1630.
GeneIDi5654586.
KEGGilma:LMJF_33_1630.

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
InParanoidiQ4Q424.
KOiK01802.
OMAiVIPAFMC.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4Q424_LEIMA
AccessioniPrimary (citable) accession number: Q4Q424
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.