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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

CYP4

Organism
Leishmania major
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
Gene namesi
Name:CYP4Imported
ORF Names:LMJF_33_1630Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 33

Organism-specific databases

EuPathDBiTriTrypDB:LmjF.33.1630

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.33.1630

Structurei

3D structure databases

ProteinModelPortaliQ4Q424
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 216PPIase cyclophilin-typeInterPro annotationAdd BLAST167

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
HOGENOMiHOG000065981
InParanoidiQ4Q424
KOiK01802
OMAiVPFHRVM

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4Q424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSEALVISY FLRSCSLKVS LPPKMLRRTF LSAERRIPFY PINSNNPIVF
60 70 80 90 100
FDISIGSQPA GRVEMELFKD VVPKTAENFR ALCTGEKGVG RSGKPLWFKG
110 120 130 140 150
SRFHRVIPQF MCQGGDFTAG NGTGGESIYG HKFPDESFAG RAGRHFGPGT
160 170 180 190 200
LSMANAGPNT NGSQFFICTA PTDWLDGKHV VFGQVTKGYD VIMKVETQGS
210 220
QSGATRQPIT VTDCGEIKQE
Length:220
Mass (Da):24,091
Last modified:July 19, 2005 - v1
Checksum:i5F18D5ED77BDC35F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796429 Genomic DNA Translation: CAJ06422.1
RefSeqiXP_001685924.1, XM_001685872.1

Genome annotation databases

EnsemblProtistsiLmjF.33.1630:mRNA; LmjF.33.1630:pep; LmjF.33.1630
GeneDBiLmjF.33.1630:pep
GeneIDi5654586
KEGGilma:LMJF_33_1630

Similar proteinsi

Entry informationi

Entry nameiQ4Q424_LEIMA
AccessioniPrimary (citable) accession number: Q4Q424
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health