Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4Q3K2 (Q4Q3K2_LEIMA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
EC=1.11.1.11 EMBL CAJ07706.1
Gene names
Name:APX EMBL CAJ07706.1
ORF Names:LMJF_34_0070 EMBL CAJ07706.1
OrganismLeishmania major [Reference proteome]
Taxonomic identifier5664 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the peroxidase family. RuleBase RU004241

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding691Calcium
Metal binding691Magnesium PDB 4GED
Metal binding721Calcium
Metal binding721Magnesium PDB 4GED
Metal binding811Calcium; via carbonyl oxygen
Metal binding811Magnesium; via carbonyl oxygen PDB 4GED
Metal binding861Calcium
Metal binding861Magnesium PDB 4GED
Metal binding921Calcium
Metal binding921Magnesium PDB 4GED
Metal binding1921Iron (heme axial ligand); via tele nitrogen PDB 4GED PDB 3RIW PDB 3RIV
Metal binding1931Potassium PDB 4GED PDB 3RIW PDB 3RIV
Metal binding2091Potassium PDB 4GED PDB 3RIW PDB 3RIV
Metal binding2111Potassium; via carbonyl oxygen PDB 4GED PDB 3RIW PDB 3RIV
Metal binding2141Potassium; via carbonyl oxygen PDB 4GED PDB 3RIW PDB 3RIV
Metal binding2181Potassium PDB 4GED PDB 3RIW PDB 3RIV

Sequences

Sequence LengthMass (Da)Tools
Q4Q3K2 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: B30DB35ACC26E8F0

FASTA30333,873
        10         20         30         40         50         60 
MSGTSRRAKG LFTGIAVGTF VSGAMFVSCA SARVEEPPFD IRALRADIED MISEKLELGP 

        70         80         90        100        110        120 
SLIRLAWHEA ASYDCFKKDG SPNSASMRFK PECLYAGNKG LDIPRKALET LKKKYPQISY 

       130        140        150        160        170        180 
ADLWVLAAYV AIEYMGGPTI PFCWGRVDAK DGSVCGPDGR LPDGSKTQSH VREVFRRLGF 

       190        200        210        220        230        240 
NDQETVALIG AHTCGECHIE FSGYHGPWTH DKNGFDNSFF TQLLDEDWVL NPKVEQMQLM 

       250        260        270        280        290        300 
DRATTKLMML PSDVCLLLDP SYRKYVELYA KDNDRFNKDF ANAFKKLTEL GTRNLHKAPA 


SES 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the kinetoplastid parasite, Leishmania major."
Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G. expand/collapse author list , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MHOM/IL/81/Friedlin.
[2]"Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania."
Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A., Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C.
Genome Res. 21:2129-2142(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Friedlin EMBL CAJ07706.1.
[3]"Crystal structure of Leishmania major peroxidase and characterization of the compound i tryptophan radical."
Jasion V.S., Polanco J.A., Meharenna Y.T., Li H., Poulos T.L.
J. Biol. Chem. 286:24608-24615(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 35-303 IN COMPLEX WITH CALCIUM; HEME AND POTASSIUM.
[4]"Crystal structure of the Leishmania major peroxidase-cytochrome c complex."
Jasion V.S., Doukov T., Pineda S.H., Li H., Poulos T.L.
Proc. Natl. Acad. Sci. U.S.A. 109:18390-18394(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 35-301 IN COMPLEX WITH HEME; MAGNESIUM AND POTASSIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR796430 Genomic DNA. Translation: CAJ07706.1.
RefSeqXP_001686096.1. XM_001686044.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3RIVX-ray1.76A/B35-303[»]
3RIWX-ray2.37A/B35-303[»]
4GEDX-ray1.84A35-301[»]
ProteinModelPortalQ4Q3K2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60328N.

Protein family/group databases

PeroxiBase2334. LmAPx-CcP.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsLmjF.34.0070:mRNA; LmjF.34.0070:pep; LmjF.34.0070.
GeneID5654759.
KEGGlma:LMJF_34_0070.

Phylogenomic databases

HOGENOMHOG000189824.
KOK00434.
OMAHTCGECH.

Family and domain databases

InterProIPR002207. Asc_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSPR00459. ASPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMSSF48113. SSF48113. 1 hit.
PROSITEPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4Q3K2_LEIMA
AccessionPrimary (citable) accession number: Q4Q3K2
Entry history
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)