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Protein
Submitted name:

Ascorbate peroxidase

Gene

APX

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Calcium 1Combined sources1
Metal bindingi69Calcium 2Combined sources1
Metal bindingi72Calcium 1Combined sources1
Metal bindingi72Calcium 2Combined sources1
Metal bindingi81Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi81Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi86Calcium 1Combined sources1
Metal bindingi92Calcium 1Combined sources1
Metal bindingi92Calcium 2Combined sources1
Metal bindingi192Iron (heme axial ligand); via tele nitrogenCombined sources1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: GeneDB
  • cytochrome-c peroxidase activity Source: GO_Central
  • heme binding Source: InterPro
  • iodide peroxidase activity Source: GeneDB
  • L-ascorbate oxidase activity Source: GeneDB
  • L-ascorbate peroxidase activity Source: GeneDB
  • metal ion binding Source: UniProtKB-KW
  • peroxidase activity Source: GeneDB

GO - Biological processi

  • calcium ion homeostasis Source: GeneDB
  • cellular response to oxidative stress Source: GO_Central
  • hydrogen peroxide catabolic process Source: GeneDB
  • negative regulation of apoptotic process Source: GeneDB
  • reactive oxygen species metabolic process Source: GeneDB
  • response to drug Source: GeneDB
  • response to reactive oxygen species Source: GeneDB
  • stabilization of membrane potential Source: GeneDB

Keywordsi

Molecular functionOxidoreductase, PeroxidaseImported
LigandCalciumCombined sources, HemeCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.11.1.11. 2950.

Protein family/group databases

PeroxiBasei2334. LmAPx-CcP.

Names & Taxonomyi

Protein namesi
Submitted name:
Ascorbate peroxidaseImported (EC:1.11.1.11Imported)
Gene namesi
Name:APXImported
ORF Names:LMJF_34_0070Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 34

Subcellular locationi

GO - Cellular componenti

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LMJF_16_1320Q4QEN52EBI-16019391,EBI-16019427

Protein-protein interaction databases

DIPiDIP-60328N.
IntActiQ4Q3K2. 1 interactor.
STRINGi5664.LmjF.34.0070.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RIVX-ray1.76A/B35-303[»]
3RIWX-ray2.37A/B35-303[»]
4GEDX-ray1.84A35-301[»]
5AL9X-ray1.37A35-303[»]
5ALAX-ray2.73A/B35-303[»]
5AMMX-ray2.09A/B35-303[»]
ProteinModelPortaliQ4Q3K2.
SMRiQ4Q3K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 303PEROXIDASE_4InterPro annotationAdd BLAST260

Sequence similaritiesi

Belongs to the peroxidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IF5T. Eukaryota.
COG0376. LUCA.
HOGENOMiHOG000189824.
InParanoidiQ4Q3K2.
KOiK00434.

Family and domain databases

InterProiView protein in InterPro
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR002207. Peroxidase_I.
IPR019794. Peroxidases_AS.
PfamiView protein in Pfam
PF00141. peroxidase. 1 hit.
PRINTSiPR00459. ASPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiView protein in PROSITE
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4Q3K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTSRRAKG LFTGIAVGTF VSGAMFVSCA SARVEEPPFD IRALRADIED
60 70 80 90 100
MISEKLELGP SLIRLAWHEA ASYDCFKKDG SPNSASMRFK PECLYAGNKG
110 120 130 140 150
LDIPRKALET LKKKYPQISY ADLWVLAAYV AIEYMGGPTI PFCWGRVDAK
160 170 180 190 200
DGSVCGPDGR LPDGSKTQSH VREVFRRLGF NDQETVALIG AHTCGECHIE
210 220 230 240 250
FSGYHGPWTH DKNGFDNSFF TQLLDEDWVL NPKVEQMQLM DRATTKLMML
260 270 280 290 300
PSDVCLLLDP SYRKYVELYA KDNDRFNKDF ANAFKKLTEL GTRNLHKAPA

SES
Length:303
Mass (Da):33,873
Last modified:July 19, 2005 - v1
Checksum:iB30DB35ACC26E8F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796430 Genomic DNA. Translation: CAJ07706.1.
RefSeqiXP_001686096.1. XM_001686044.1.

Genome annotation databases

EnsemblProtistsiLmjF.34.0070:mRNA; LmjF.34.0070:pep; LmjF.34.0070.
GeneDBiLmjF.34.0070:pep.
GeneIDi5654759.
KEGGilma:LMJF_34_0070.

Similar proteinsi

Entry informationi

Entry nameiQ4Q3K2_LEIMA
AccessioniPrimary (citable) accession number: Q4Q3K2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported