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Q4Q3K2

- Q4Q3K2_LEIMA

UniProt

Q4Q3K2 - Q4Q3K2_LEIMA

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Protein
Submitted name:

Ascorbate peroxidase

Gene

APX

Organism
Leishmania major
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691CalciumImported
Metal bindingi69 – 691MagnesiumImported
Metal bindingi72 – 721CalciumImported
Metal bindingi72 – 721MagnesiumImported
Metal bindingi81 – 811Calcium; via carbonyl oxygenImported
Metal bindingi81 – 811Magnesium; via carbonyl oxygenImported
Metal bindingi86 – 861CalciumImported
Metal bindingi86 – 861MagnesiumImported
Metal bindingi92 – 921CalciumImported
Metal bindingi92 – 921MagnesiumImported
Metal bindingi192 – 1921Iron (heme axial ligand); via tele nitrogenImported

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: GeneDB_Lmajor
  2. heme binding Source: InterPro
  3. iodide peroxidase activity Source: GeneDB_Lmajor
  4. L-ascorbate oxidase activity Source: GeneDB_Lmajor
  5. L-ascorbate peroxidase activity Source: GeneDB_Lmajor
  6. metal ion binding Source: UniProtKB-KW
  7. peroxidase activity Source: GeneDB_Lmajor

GO - Biological processi

  1. calcium ion homeostasis Source: GeneDB_Lmajor
  2. hydrogen ion transmembrane transport Source: GOC
  3. hydrogen peroxide catabolic process Source: GeneDB_Lmajor
  4. negative regulation of apoptotic process Source: GeneDB_Lmajor
  5. reactive oxygen species metabolic process Source: GeneDB_Lmajor
  6. response to drug Source: GeneDB_Lmajor
  7. response to reactive oxygen species Source: GeneDB_Lmajor
  8. stabilization of membrane potential Source: GeneDB_Lmajor
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, PeroxidaseImported

Keywords - Ligandi

CalciumImported, HemeImported, Iron, MagnesiumImported, Metal-binding

Protein family/group databases

PeroxiBasei2334. LmAPx-CcP.

Names & Taxonomyi

Protein namesi
Submitted name:
Ascorbate peroxidaseImported (EC:1.11.1.11Imported)
Gene namesi
Name:APXImported
ORF Names:LMJF_34_0070Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000000542: Chromosome 34

Subcellular locationi

GO - Cellular componenti

  1. intrinsic component of mitochondrial inner membrane Source: GeneDB_Lmajor
Complete GO annotation...

Interactioni

Protein-protein interaction databases

DIPiDIP-60328N.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RIVX-ray1.76A/B35-303[»]
3RIWX-ray2.37A/B35-303[»]
4GEDX-ray1.84A35-301[»]
ProteinModelPortaliQ4Q3K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000189824.
InParanoidiQ4Q3K2.
KOiK00434.
OMAiHTCGECH.

Family and domain databases

InterProiIPR002207. Asc_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00459. ASPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4Q3K2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTSRRAKG LFTGIAVGTF VSGAMFVSCA SARVEEPPFD IRALRADIED
60 70 80 90 100
MISEKLELGP SLIRLAWHEA ASYDCFKKDG SPNSASMRFK PECLYAGNKG
110 120 130 140 150
LDIPRKALET LKKKYPQISY ADLWVLAAYV AIEYMGGPTI PFCWGRVDAK
160 170 180 190 200
DGSVCGPDGR LPDGSKTQSH VREVFRRLGF NDQETVALIG AHTCGECHIE
210 220 230 240 250
FSGYHGPWTH DKNGFDNSFF TQLLDEDWVL NPKVEQMQLM DRATTKLMML
260 270 280 290 300
PSDVCLLLDP SYRKYVELYA KDNDRFNKDF ANAFKKLTEL GTRNLHKAPA

SES
Length:303
Mass (Da):33,873
Last modified:July 19, 2005 - v1
Checksum:iB30DB35ACC26E8F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796430 Genomic DNA. Translation: CAJ07706.1.
RefSeqiXP_001686096.1. XM_001686044.1.

Genome annotation databases

EnsemblProtistsiLmjF.34.0070:mRNA; LmjF.34.0070:pep; LmjF.34.0070.
GeneIDi5654759.
KEGGilma:LMJF_34_0070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR796430 Genomic DNA. Translation: CAJ07706.1 .
RefSeqi XP_001686096.1. XM_001686044.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RIV X-ray 1.76 A/B 35-303 [» ]
3RIW X-ray 2.37 A/B 35-303 [» ]
4GED X-ray 1.84 A 35-301 [» ]
ProteinModelPortali Q4Q3K2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60328N.

Protein family/group databases

PeroxiBasei 2334. LmAPx-CcP.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi LmjF.34.0070:mRNA ; LmjF.34.0070:pep ; LmjF.34.0070 .
GeneIDi 5654759.
KEGGi lma:LMJF_34_0070.

Phylogenomic databases

HOGENOMi HOG000189824.
InParanoidi Q4Q3K2.
KOi K00434.
OMAi HTCGECH.

Family and domain databases

InterProi IPR002207. Asc_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view ]
Pfami PF00141. peroxidase. 1 hit.
[Graphical view ]
PRINTSi PR00459. ASPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MHOM/IL/81/FriedlinImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported.
  3. "Crystal structure of Leishmania major peroxidase and characterization of the compound i tryptophan radical."
    Jasion V.S., Polanco J.A., Meharenna Y.T., Li H., Poulos T.L.
    J. Biol. Chem. 286:24608-24615(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 35-303 IN COMPLEX WITH CALCIUM AND HEME.
  4. "Crystal structure of the Leishmania major peroxidase-cytochrome c complex."
    Jasion V.S., Doukov T., Pineda S.H., Li H., Poulos T.L.
    Proc. Natl. Acad. Sci. U.S.A. 109:18390-18394(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 35-301 IN COMPLEX WITH HEME AND MAGNESIUM.

Entry informationi

Entry nameiQ4Q3K2_LEIMA
AccessioniPrimary (citable) accession number: Q4Q3K2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3