Reviewed,
UniProtKB/Swiss-Prot Q4PRC2 (DCE2_CANFA)
Last modified
October 13, 2009.
Version 39.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glutamate decarboxylase 2 EC=4.1.1.15 Alternative name(s): Glutamate decarboxylase 65 kDa isoform 65 kDa glutamic acid decarboxylase GAD-65 | ||||
| Gene names |
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| Organism | Canis familiaris (Dog) | ||||
| Taxonomic identifier | 9615 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis |
Protein attributes
| Sequence length | 585 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the production of GABA. |
| Catalytic activity | L-glutamate = 4-aminobutanoate + CO2. |
| Cofactor | Pyridoxal phosphate. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm › cytosol By similarity. Cytoplasmic vesicle By similarity. Cell junction › synapse › presynaptic cell membrane; Lipid-anchor By similarity. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters By similarity. |
| Post-translational modification | Phosphorylated; which does not affect kinetic parameters or subcellular location By similarity. Palmitoylated; which is required for presynaptic clustering By similarity. |
| Sequence similarities | Belongs to the group II decarboxylase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 585 | 585 | Glutamate decarboxylase 2 | PRO_0000231042 | |||||
Regions | |||||||||
| Region | 181 – 183 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 558 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 3 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 6 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 10 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 13 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 396 | 1 | N6-(pyridoxal phosphate)lysine By similarity | ||||||
| Lipidation | 30 | 1 | S-palmitoyl cysteine By similarity | ||||||
| Lipidation | 45 | 1 | S-palmitoyl cysteine By similarity | ||||||
Sequences
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References
| [1] | "Autoantibodies to recombinant canine GAD65 in canine diabetes mellitus." Davison L.J., Weenink S.M., Christie M.R., Herrtage M.E., Catchpole B. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Sequences of canine glutamate decarboxylase (GAD) 1 and GAD2 genes, and variation of their genetic polymorphisms among five dog breeds." Arata S., Hashizume C., Kikusui T., Takeuchi Y., Mori Y. J. Vet. Med. Sci. 70:1107-1110(2008) [PubMed: 18981669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| DQ060442 mRNA. Translation: AAY59421.1. AB261623 mRNA. Translation: BAF37948.1. | |
| RefSeq | NP_001070907.1. |
| UniGene | Cfa.24099 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q4PRC2. |
Genome annotation databases | |
| Ensembl | ENSCAFT00000006929; ENSCAFP00000006413; ENSCAFG00000004299; Canis familiaris. [Genome view] |
| GeneID | 487107. |
| KEGG | cfa:487107. |
Organism-specific databases | |
| CTD | 487107. |
Phylogenomic databases | |
| HOVERGEN | Q4PRC2. |
Enzyme and pathway databases | |
| BRENDA | 4.1.1.15. 463. |
Family and domain databases | |
| InterPro | IPR002129. PyrdxlP-dep_de-COase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view] |
| Gene3D | G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. |
| PANTHER | PTHR11999. Pyridoxal_deC. 1 hit. |
| Pfam | PF00282. Pyridoxal_deC. 1 hit. [Graphical view] |
| PROSITE | PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DCE2_CANFA | ||||||||
| Accession | Primary (citable) accession number: Q4PRC2 Secondary accession number(s): A0PA84 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
