ID   CCL25_PIG               Reviewed;         151 AA.
AC   Q4PR21;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   24-JAN-2024, entry version 93.
DE   RecName: Full=C-C motif chemokine 25;
DE   AltName: Full=Chemokine ligand 25;
DE   AltName: Full=Small-inducible cytokine A25;
DE   Flags: Precursor;
GN   Name=CCL25;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Berri M., Meurens F., Whale J., Brownlie R., Gerdts V., Chevaleyre C.,
RA   Salmon H.;
RT   "Sus scrofa chemokine (C-C motif) ligand 25 sequence.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potentially involved in T-cell development. Recombinant
CC       protein shows chemotactic activity on thymocytes, macrophages, THP-1
CC       cells, and dendritics cells but is inactive on peripheral blood
CC       lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine
CC       receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2)
CC       to ACKR4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; DQ061157; AAY67883.1; -; mRNA.
DR   RefSeq; NP_001020385.1; NM_001025214.1.
DR   RefSeq; XP_005661315.1; XM_005661258.2.
DR   RefSeq; XP_005661316.1; XM_005661259.2.
DR   AlphaFoldDB; Q4PR21; -.
DR   SMR; Q4PR21; -.
DR   STRING; 9823.ENSSSCP00000069059; -.
DR   PaxDb; 9823-ENSSSCP00000014444; -.
DR   PeptideAtlas; Q4PR21; -.
DR   Ensembl; ENSSSCT00000047746.3; ENSSSCP00000045987.1; ENSSSCG00000013593.6.
DR   Ensembl; ENSSSCT00005033508.1; ENSSSCP00005020450.1; ENSSSCG00005021195.1.
DR   Ensembl; ENSSSCT00015089639.1; ENSSSCP00015036595.1; ENSSSCG00015066934.1.
DR   Ensembl; ENSSSCT00025021545.1; ENSSSCP00025008865.1; ENSSSCG00025016057.1.
DR   Ensembl; ENSSSCT00030010273.1; ENSSSCP00030004412.1; ENSSSCG00030007657.1.
DR   Ensembl; ENSSSCT00035105717.1; ENSSSCP00035045450.1; ENSSSCG00035077557.1.
DR   Ensembl; ENSSSCT00040005039.1; ENSSSCP00040001726.1; ENSSSCG00040003963.1.
DR   Ensembl; ENSSSCT00045058411.1; ENSSSCP00045040833.1; ENSSSCG00045034044.1.
DR   Ensembl; ENSSSCT00050068409.1; ENSSSCP00050029349.1; ENSSSCG00050050284.1.
DR   Ensembl; ENSSSCT00055024658.1; ENSSSCP00055019567.1; ENSSSCG00055012540.1.
DR   Ensembl; ENSSSCT00060024110.1; ENSSSCP00060010114.1; ENSSSCG00060017990.1.
DR   Ensembl; ENSSSCT00065077245.1; ENSSSCP00065033569.1; ENSSSCG00065056447.1.
DR   Ensembl; ENSSSCT00070051060.1; ENSSSCP00070043180.1; ENSSSCG00070025542.1.
DR   GeneID; 448799; -.
DR   KEGG; ssc:448799; -.
DR   CTD; 6370; -.
DR   VGNC; VGNC:99612; CCL25.
DR   eggNOG; ENOG502S8D1; Eukaryota.
DR   GeneTree; ENSGT01100000263557; -.
DR   HOGENOM; CLU_113773_0_0_1; -.
DR   InParanoid; Q4PR21; -.
DR   OMA; RAWAYRI; -.
DR   OrthoDB; 5355241at2759; -.
DR   TreeFam; TF353160; -.
DR   Reactome; R-SSC-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-SSC-418594; G alpha (i) signalling events.
DR   Proteomes; UP000008227; Chromosome 2.
DR   Proteomes; UP000314985; Chromosome 2.
DR   Proteomes; UP000694570; Unplaced.
DR   Proteomes; UP000694571; Unplaced.
DR   Proteomes; UP000694720; Unplaced.
DR   Proteomes; UP000694722; Unplaced.
DR   Proteomes; UP000694723; Unplaced.
DR   Proteomes; UP000694724; Unplaced.
DR   Proteomes; UP000694725; Unplaced.
DR   Proteomes; UP000694726; Unplaced.
DR   Proteomes; UP000694727; Unplaced.
DR   Proteomes; UP000694728; Unplaced.
DR   Bgee; ENSSSCG00000013593; Expressed in duodenum and 42 other cell types or tissues.
DR   ExpressionAtlas; Q4PR21; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0031735; F:CCR10 chemokine receptor binding; IEA:Ensembl.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0042379; F:chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:1903237; P:negative regulation of leukocyte tethering or rolling; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF70; C-C MOTIF CHEMOKINE 25; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   Genevisible; Q4PR21; SS.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..151
FT                   /note="C-C motif chemokine 25"
FT                   /id="PRO_0000231040"
FT   REGION          93..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        30..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..75
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   151 AA;  16878 MW;  01E22AF59AFFAC57 CRC64;
     MRPWLLACLV ACFVGAWAPA IHAQGAFEDC CLAYHSHIKW RLLRRAHSYQ RQDVSGSCNL
     PAVIFFFPQK DKMVCGKPGA KWVQFGMKIL DNRNKKDSKP HHSGRRFFQG PQSGVRKLSS
     GTSRPLLLKF SGPTRSSKRK ASLLTTAIPG P
//