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Protein

C-C motif chemokine 25

Gene

CCL25

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-SSC-380108. Chemokine receptors bind chemokines.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine ligand 25
Small-inducible cytokine A25
Gene namesi
Name:CCL25
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000023104024 – 151C-C motif chemokine 25Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ4PR21.
PeptideAtlasiQ4PR21.
PRIDEiQ4PR21.

Expressioni

Gene expression databases

GenevisibleiQ4PR21. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014444.

Structurei

3D structure databases

ProteinModelPortaliQ4PR21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J09B. Eukaryota.
ENOG410Z7F2. LUCA.
GeneTreeiENSGT00860000133912.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
InParanoidiQ4PR21.
KOiK13072.
OMAiAWAPAVH.
OrthoDBiEOG091G0VC0.
TreeFamiTF353160.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4PR21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPWLLACLV ACFVGAWAPA IHAQGAFEDC CLAYHSHIKW RLLRRAHSYQ
60 70 80 90 100
RQDVSGSCNL PAVIFFFPQK DKMVCGKPGA KWVQFGMKIL DNRNKKDSKP
110 120 130 140 150
HHSGRRFFQG PQSGVRKLSS GTSRPLLLKF SGPTRSSKRK ASLLTTAIPG

P
Length:151
Mass (Da):16,878
Last modified:July 19, 2005 - v1
Checksum:i01E22AF59AFFAC57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ061157 mRNA. Translation: AAY67883.1.
RefSeqiNP_001020385.1. NM_001025214.1.
XP_005661315.1. XM_005661258.2.
XP_005661316.1. XM_005661259.2.
UniGeneiSsc.97249.

Genome annotation databases

EnsembliENSSSCT00000014845; ENSSSCP00000014444; ENSSSCG00000013593.
GeneIDi448799.
KEGGissc:448799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ061157 mRNA. Translation: AAY67883.1.
RefSeqiNP_001020385.1. NM_001025214.1.
XP_005661315.1. XM_005661258.2.
XP_005661316.1. XM_005661259.2.
UniGeneiSsc.97249.

3D structure databases

ProteinModelPortaliQ4PR21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014444.

Proteomic databases

PaxDbiQ4PR21.
PeptideAtlasiQ4PR21.
PRIDEiQ4PR21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000014845; ENSSSCP00000014444; ENSSSCG00000013593.
GeneIDi448799.
KEGGissc:448799.

Organism-specific databases

CTDi6370.

Phylogenomic databases

eggNOGiENOG410J09B. Eukaryota.
ENOG410Z7F2. LUCA.
GeneTreeiENSGT00860000133912.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
InParanoidiQ4PR21.
KOiK13072.
OMAiAWAPAVH.
OrthoDBiEOG091G0VC0.
TreeFamiTF353160.

Enzyme and pathway databases

ReactomeiR-SSC-380108. Chemokine receptors bind chemokines.
R-SSC-418594. G alpha (i) signalling events.

Gene expression databases

GenevisibleiQ4PR21. SS.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCL25_PIG
AccessioniPrimary (citable) accession number: Q4PR21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.