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Q4PR21

- CCL25_PIG

UniProt

Q4PR21 - CCL25_PIG

Protein

C-C motif chemokine 25

Gene

CCL25

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 By similarity.By similarity

    GO - Molecular functioni

    1. chemokine receptor binding Source: UniProtKB

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW
    4. leukocyte migration Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_202825. G alpha (i) signalling events.
    REACT_226269. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 25
    Alternative name(s):
    Chemokine ligand 25
    Small-inducible cytokine A25
    Gene namesi
    Name:CCL25
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 2

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 151128C-C motif chemokine 25PRO_0000231040Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 58By similarity
    Disulfide bondi31 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000014444.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4PR21.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39655.
    GeneTreeiENSGT00510000049257.
    HOGENOMiHOG000293281.
    HOVERGENiHBG050832.
    KOiK13072.
    OMAiAWAPAVH.
    OrthoDBiEOG76MKB6.
    TreeFamiTF353160.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4PR21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPWLLACLV ACFVGAWAPA IHAQGAFEDC CLAYHSHIKW RLLRRAHSYQ    50
    RQDVSGSCNL PAVIFFFPQK DKMVCGKPGA KWVQFGMKIL DNRNKKDSKP 100
    HHSGRRFFQG PQSGVRKLSS GTSRPLLLKF SGPTRSSKRK ASLLTTAIPG 150
    P 151
    Length:151
    Mass (Da):16,878
    Last modified:July 19, 2005 - v1
    Checksum:i01E22AF59AFFAC57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ061157 mRNA. Translation: AAY67883.1.
    RefSeqiNP_001020385.1. NM_001025214.1.
    XP_005661315.1. XM_005661258.1.
    XP_005661316.1. XM_005661259.1.
    UniGeneiSsc.97249.

    Genome annotation databases

    EnsembliENSSSCT00000014845; ENSSSCP00000014444; ENSSSCG00000013593.
    GeneIDi448799.
    KEGGissc:448799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ061157 mRNA. Translation: AAY67883.1 .
    RefSeqi NP_001020385.1. NM_001025214.1.
    XP_005661315.1. XM_005661258.1.
    XP_005661316.1. XM_005661259.1.
    UniGenei Ssc.97249.

    3D structure databases

    ProteinModelPortali Q4PR21.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000014444.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000014845 ; ENSSSCP00000014444 ; ENSSSCG00000013593 .
    GeneIDi 448799.
    KEGGi ssc:448799.

    Organism-specific databases

    CTDi 6370.

    Phylogenomic databases

    eggNOGi NOG39655.
    GeneTreei ENSGT00510000049257.
    HOGENOMi HOG000293281.
    HOVERGENi HBG050832.
    KOi K13072.
    OMAi AWAPAVH.
    OrthoDBi EOG76MKB6.
    TreeFami TF353160.

    Enzyme and pathway databases

    Reactomei REACT_202825. G alpha (i) signalling events.
    REACT_226269. Chemokine receptors bind chemokines.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sus scrofa chemokine (C-C motif) ligand 25 sequence."
      Berri M., Meurens F., Whale J., Brownlie R., Gerdts V., Chevaleyre C., Salmon H.
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL25_PIG
    AccessioniPrimary (citable) accession number: Q4PR21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3