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Protein

C-C motif chemokine 25

Gene

CCL25

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).By similarity

GO - Molecular functioni

  1. chemokine receptor binding Source: UniProtKB

GO - Biological processi

  1. cell chemotaxis Source: Ensembl
  2. G-protein coupled receptor signaling pathway Source: Ensembl
  3. immune response Source: InterPro
  4. inflammatory response Source: UniProtKB-KW
  5. leukocyte migration Source: Ensembl
  6. negative regulation of leukocyte tethering or rolling Source: Ensembl
  7. positive regulation of cell-matrix adhesion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_202825. G alpha (i) signalling events.
REACT_226269. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine ligand 25
Small-inducible cytokine A25
Gene namesi
Name:CCL25
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 2

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 151128C-C motif chemokine 25PRO_0000231040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014444.

Structurei

3D structure databases

ProteinModelPortaliQ4PR21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39655.
GeneTreeiENSGT00510000049257.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
InParanoidiQ4PR21.
KOiK13072.
OMAiQGVFEDC.
OrthoDBiEOG76MKB6.
TreeFamiTF353160.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4PR21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPWLLACLV ACFVGAWAPA IHAQGAFEDC CLAYHSHIKW RLLRRAHSYQ
60 70 80 90 100
RQDVSGSCNL PAVIFFFPQK DKMVCGKPGA KWVQFGMKIL DNRNKKDSKP
110 120 130 140 150
HHSGRRFFQG PQSGVRKLSS GTSRPLLLKF SGPTRSSKRK ASLLTTAIPG

P
Length:151
Mass (Da):16,878
Last modified:July 19, 2005 - v1
Checksum:i01E22AF59AFFAC57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ061157 mRNA. Translation: AAY67883.1.
RefSeqiNP_001020385.1. NM_001025214.1.
XP_005661315.1. XM_005661258.1.
XP_005661316.1. XM_005661259.1.
UniGeneiSsc.97249.

Genome annotation databases

EnsembliENSSSCT00000014845; ENSSSCP00000014444; ENSSSCG00000013593.
GeneIDi448799.
KEGGissc:448799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ061157 mRNA. Translation: AAY67883.1.
RefSeqiNP_001020385.1. NM_001025214.1.
XP_005661315.1. XM_005661258.1.
XP_005661316.1. XM_005661259.1.
UniGeneiSsc.97249.

3D structure databases

ProteinModelPortaliQ4PR21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014444.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000014845; ENSSSCP00000014444; ENSSSCG00000013593.
GeneIDi448799.
KEGGissc:448799.

Organism-specific databases

CTDi6370.

Phylogenomic databases

eggNOGiNOG39655.
GeneTreeiENSGT00510000049257.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
InParanoidiQ4PR21.
KOiK13072.
OMAiQGVFEDC.
OrthoDBiEOG76MKB6.
TreeFamiTF353160.

Enzyme and pathway databases

ReactomeiREACT_202825. G alpha (i) signalling events.
REACT_226269. Chemokine receptors bind chemokines.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sus scrofa chemokine (C-C motif) ligand 25 sequence."
    Berri M., Meurens F., Whale J., Brownlie R., Gerdts V., Chevaleyre C., Salmon H.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL25_PIG
AccessioniPrimary (citable) accession number: Q4PR21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 19, 2005
Last modified: March 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.