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Q4PR21 (CCL25_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine ligand 25
Small-inducible cytokine A25
Gene names
Name:CCL25
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

leukocyte migration

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionchemokine receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 151128C-C motif chemokine 25
PRO_0000231040

Amino acid modifications

Disulfide bond30 ↔ 58 By similarity
Disulfide bond31 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4PR21 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 01E22AF59AFFAC57

FASTA15116,878
        10         20         30         40         50         60 
MRPWLLACLV ACFVGAWAPA IHAQGAFEDC CLAYHSHIKW RLLRRAHSYQ RQDVSGSCNL 

        70         80         90        100        110        120 
PAVIFFFPQK DKMVCGKPGA KWVQFGMKIL DNRNKKDSKP HHSGRRFFQG PQSGVRKLSS 

       130        140        150 
GTSRPLLLKF SGPTRSSKRK ASLLTTAIPG P 

« Hide

References

[1]"Sus scrofa chemokine (C-C motif) ligand 25 sequence."
Berri M., Meurens F., Whale J., Brownlie R., Gerdts V., Chevaleyre C., Salmon H.
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ061157 mRNA. Translation: AAY67883.1.
RefSeqNP_001020385.1. NM_001025214.1.
XP_005661315.1. XM_005661258.1.
XP_005661316.1. XM_005661259.1.
UniGeneSsc.97249.

3D structure databases

ProteinModelPortalQ4PR21.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000014444.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000014845; ENSSSCP00000014444; ENSSSCG00000013593.
GeneID448799.
KEGGssc:448799.

Organism-specific databases

CTD6370.

Phylogenomic databases

eggNOGNOG39655.
GeneTreeENSGT00510000049257.
HOGENOMHOG000293281.
HOVERGENHBG050832.
KOK13072.
OMAQGVFEDC.
OrthoDBEOG76MKB6.
TreeFamTF353160.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCCL25_PIG
AccessionPrimary (citable) accession number: Q4PR21
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 19, 2005
Last modified: March 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families