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Q4PR21

- CCL25_PIG

UniProt

Q4PR21 - CCL25_PIG

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Protein
C-C motif chemokine 25
Gene
CCL25
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 By similarity.

GO - Molecular functioni

  1. chemokine receptor binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
  4. leukocyte migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_202825. G alpha (i) signalling events.
REACT_226269. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine ligand 25
Small-inducible cytokine A25
Gene namesi
Name:CCL25
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 2

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 151128C-C motif chemokine 25
PRO_0000231040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 58 By similarity
Disulfide bondi31 ↔ 75 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014444.

Structurei

3D structure databases

ProteinModelPortaliQ4PR21.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39655.
GeneTreeiENSGT00510000049257.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
KOiK13072.
OMAiAWAPAVH.
OrthoDBiEOG76MKB6.
TreeFamiTF353160.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4PR21-1 [UniParc]FASTAAdd to Basket

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MRPWLLACLV ACFVGAWAPA IHAQGAFEDC CLAYHSHIKW RLLRRAHSYQ    50
RQDVSGSCNL PAVIFFFPQK DKMVCGKPGA KWVQFGMKIL DNRNKKDSKP 100
HHSGRRFFQG PQSGVRKLSS GTSRPLLLKF SGPTRSSKRK ASLLTTAIPG 150
P 151
Length:151
Mass (Da):16,878
Last modified:July 19, 2005 - v1
Checksum:i01E22AF59AFFAC57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ061157 mRNA. Translation: AAY67883.1.
RefSeqiNP_001020385.1. NM_001025214.1.
XP_005661315.1. XM_005661258.1.
XP_005661316.1. XM_005661259.1.
UniGeneiSsc.97249.

Genome annotation databases

EnsembliENSSSCT00000014845; ENSSSCP00000014444; ENSSSCG00000013593.
GeneIDi448799.
KEGGissc:448799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ061157 mRNA. Translation: AAY67883.1 .
RefSeqi NP_001020385.1. NM_001025214.1.
XP_005661315.1. XM_005661258.1.
XP_005661316.1. XM_005661259.1.
UniGenei Ssc.97249.

3D structure databases

ProteinModelPortali Q4PR21.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000014444.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000014845 ; ENSSSCP00000014444 ; ENSSSCG00000013593 .
GeneIDi 448799.
KEGGi ssc:448799.

Organism-specific databases

CTDi 6370.

Phylogenomic databases

eggNOGi NOG39655.
GeneTreei ENSGT00510000049257.
HOGENOMi HOG000293281.
HOVERGENi HBG050832.
KOi K13072.
OMAi AWAPAVH.
OrthoDBi EOG76MKB6.
TreeFami TF353160.

Enzyme and pathway databases

Reactomei REACT_202825. G alpha (i) signalling events.
REACT_226269. Chemokine receptors bind chemokines.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sus scrofa chemokine (C-C motif) ligand 25 sequence."
    Berri M., Meurens F., Whale J., Brownlie R., Gerdts V., Chevaleyre C., Salmon H.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL25_PIG
AccessioniPrimary (citable) accession number: Q4PR21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 19, 2005
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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