ID   GPD_CANTR               Reviewed;         391 AA.
AC   Q4PNS1;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD+];
DE            EC=1.1.1.8;
GN   Name=GPD;
OS   Candida tropicalis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales;
OC   Candida.
OX   NCBI_TaxID=5482;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   He F., Chen Y.;
RT   "Isolation of the glycerol-3-phosphate dehydrogenase gene from Candida
RT   tropicalis and its application to gene expression in Saccharomyces
RT   cerevisiae.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD(+) = glycerone
CC       phosphate + NADH.
CC   -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate
CC       dehydrogenase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DQ064595; AAY63996.1; -; Genomic_DNA.
DR   BRENDA; 1.1.1.8; 1242.
DR   GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR   GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase (NAD+) a...; IEA:EC.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006168; NAD-dep_Gly3P_DH.
DR   InterPro; IPR017751; NAD-dep_Gly3P_DH_euk.
DR   InterPro; IPR011128; NAD-dep_Gly3P_DH_N.
DR   InterPro; IPR006109; NAD_Gly3P_DH_C.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   PANTHER; PTHR11728; NAD_Gly3P_DH; 1.
DR   Pfam; PF07479; NAD_Gly3P_dh_C; 1.
DR   Pfam; PF01210; NAD_Gly3P_dh_N; 1.
DR   PIRSF; PIRSF000114; Glycerol-3-P_dh; 1.
DR   PRINTS; PR00077; GPDHDRGNASE.
DR   ProDom; PD001278; NAD_Gly3P_C; 1.
DR   TIGRFAMs; TIGR03376; glycerol3P_DH; 1.
DR   PROSITE; PS00957; NAD_G3PDH; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN         1    391       Glycerol-3-phosphate dehydrogenase
FT                                [NAD+].
FT                                /FTId=PRO_0000138088.
FT   NP_BIND      46     51       NAD (By similarity).
FT   REGION      315    316       Substrate binding (By similarity).
FT   ACT_SITE    250    250       Proton acceptor (By similarity).
FT   BINDING     134    134       NAD (By similarity).
FT   BINDING     157    157       NAD; via amide nitrogen (By similarity).
FT   BINDING     157    157       Substrate (By similarity).
FT   BINDING     190    190       NAD; via amide nitrogen (By similarity).
FT   BINDING     315    315       NAD (By similarity).
FT   BINDING     344    344       NAD (By similarity).
SQ   SEQUENCE   391 AA;  42536 MW;  B409DA55F000945D CRC64;
     MCTSANNRLD QLTQILHPEN LLNPTNASHP ESSLRPDHPF KIAVVGSGNW GTTIAKIVSE
     NAVARPHLFS HFVNMWVFEE KIDGTNLTEI INTRHENIKY LPGVKLPKNL IAVPDIVKAV
     KGADLIVFNL PHQFLPRILK QLKGHVPKTT RAISCLKGLE VNANGCKLLS TVIEEELGIA
     CGALSGANLA PEIARGNWSE TTVAYRVPAD YRGPGKDIDK LVLKALFHRP YFHVNVIDDV
     AGVSIAGALK NVVALAVGFV EGLGWGDNAK AAVMRVGLLE TIKFAKLFFN DAEIDTFTGE
     SAGVADLITT CSGGRNVKVG RYMAETGCAA EEAEKKLLNG QSSQGIVTTK EVHEFLTNVN
     KLEEFPLFEA TYQITFGSES IENLPNLLNN Y
//