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Q4PNS1

- GPD_CANTR

UniProt

Q4PNS1 - GPD_CANTR

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Protein
Glycerol-3-phosphate dehydrogenase [NAD(+)]
Gene
GPD
Organism
Candida tropicalis (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341NAD By similarity
Binding sitei157 – 1571NAD; via amide nitrogen By similarity
Binding sitei157 – 1571Substrate By similarity
Binding sitei190 – 1901NAD; via amide nitrogen By similarity
Active sitei250 – 2501Proton acceptor By similarity
Binding sitei315 – 3151NAD By similarity
Binding sitei344 – 3441NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 516NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:GPD
OrganismiCandida tropicalis (Yeast)
Taxonomic identifieri5482 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Glycerol-3-phosphate dehydrogenase [NAD(+)]
PRO_0000138088Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4PNS1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni315 – 3162Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4PNS1-1 [UniParc]FASTAAdd to Basket

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MCTSANNRLD QLTQILHPEN LLNPTNASHP ESSLRPDHPF KIAVVGSGNW    50
GTTIAKIVSE NAVARPHLFS HFVNMWVFEE KIDGTNLTEI INTRHENIKY 100
LPGVKLPKNL IAVPDIVKAV KGADLIVFNL PHQFLPRILK QLKGHVPKTT 150
RAISCLKGLE VNANGCKLLS TVIEEELGIA CGALSGANLA PEIARGNWSE 200
TTVAYRVPAD YRGPGKDIDK LVLKALFHRP YFHVNVIDDV AGVSIAGALK 250
NVVALAVGFV EGLGWGDNAK AAVMRVGLLE TIKFAKLFFN DAEIDTFTGE 300
SAGVADLITT CSGGRNVKVG RYMAETGCAA EEAEKKLLNG QSSQGIVTTK 350
EVHEFLTNVN KLEEFPLFEA TYQITFGSES IENLPNLLNN Y 391
Length:391
Mass (Da):42,536
Last modified:July 19, 2005 - v1
Checksum:iB409DA55F000945D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ064595 Genomic DNA. Translation: AAY63996.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ064595 Genomic DNA. Translation: AAY63996.1 .

3D structure databases

ProteinModelPortali Q4PNS1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of the glycerol-3-phosphate dehydrogenase gene from Candida tropicalis and its application to gene expression in Saccharomyces cerevisiae."
    He F., Chen Y.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGPD_CANTR
AccessioniPrimary (citable) accession number: Q4PNS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 19, 2005
Last modified: October 16, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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