Reviewed, UniProtKB/Swiss-Prot Q4PNS1 (GPD_CANTR)

Names and origin

Protein names

Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD+]
    EC=1.1.1.8

Gene names

Name:

GPD

Organism

Candida tropicalis (Yeast)

Taxonomic identifier

5482 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.
Sequence similarities	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glycerol-3-phosphate catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: EC protein homodimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Glycerol-3-phosphate dehydrogenase [NAD+]		PRO_0000138088
Regions
	Nucleotide binding	46 – 51	6	NAD By similarity
	Region	315 – 316	2	Substrate binding By similarity
Sites
	Active site	250	1	Proton acceptor By similarity
	Binding site	134	1	NAD By similarity
	Binding site	157	1	NAD; via amide nitrogen By similarity
	Binding site	157	1	Substrate By similarity
	Binding site	190	1	NAD; via amide nitrogen By similarity
	Binding site	315	1	NAD By similarity
	Binding site	344	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4PNS1-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: B409DA55F000945D	FASTA	391	42,536
	10 20 30 40 50 60 MCTSANNRLD QLTQILHPEN LLNPTNASHP ESSLRPDHPF KIAVVGSGNW GTTIAKIVSE 70 80 90 100 110 120 NAVARPHLFS HFVNMWVFEE KIDGTNLTEI INTRHENIKY LPGVKLPKNL IAVPDIVKAV 130 140 150 160 170 180 KGADLIVFNL PHQFLPRILK QLKGHVPKTT RAISCLKGLE VNANGCKLLS TVIEEELGIA 190 200 210 220 230 240 CGALSGANLA PEIARGNWSE TTVAYRVPAD YRGPGKDIDK LVLKALFHRP YFHVNVIDDV 250 260 270 280 290 300 AGVSIAGALK NVVALAVGFV EGLGWGDNAK AAVMRVGLLE TIKFAKLFFN DAEIDTFTGE 310 320 330 340 350 360 SAGVADLITT CSGGRNVKVG RYMAETGCAA EEAEKKLLNG QSSQGIVTTK EVHEFLTNVN 370 380 390 KLEEFPLFEA TYQITFGSES IENLPNLLNN Y

References

[1]	"Isolation of the glycerol-3-phosphate dehydrogenase gene from Candida tropicalis and its application to gene expression in Saccharomyces cerevisiae." He F., Chen Y. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ064595 Genomic DNA. Translation: AAY63996.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.8. 1242.
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. IPR006168. NAD-dep_Gly3P_DH. IPR017751. NAD-dep_Gly3P_DH_euk. IPR011128. NAD-dep_Gly3P_DH_N. IPR006109. NAD_Gly3P_DH_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR11728. NAD_Gly3P_DH. 1 hit.
Pfam	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PIRSF	PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTS	PR00077. GPDHDRGNASE.
ProDom	PD001278. NAD_Gly3P_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03376. glycerol3P_DH. 1 hit.
PROSITE	PS00957. NAD_G3PDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPD_CANTR

Accession

Primary (citable) accession number: Q4PNS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	July 19, 2005
Last modified:	September 22, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)