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Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2

Gene

Nkain2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2
Short name:
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2
Alternative name(s):
T-cell lymphoma breakpoint-associated target protein 1
Gene namesi
Name:Nkain2
Synonyms:Tcba1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1923447. Nkain2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 23HelicalSequence analysisAdd BLAST23
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002650891 – 208Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2Add BLAST208

Proteomic databases

PRIDEiQ4PNJ2.

PTM databases

PhosphoSitePlusiQ4PNJ2.

Expressioni

Tissue specificityi

Detected in the brain only and specifically in neurons; expressed in multiple regions such as cerebral cortex, thalamus, cerebellum, olfactory bulb and brainstem, but not in the hippocampus.1 Publication

Gene expression databases

BgeeiENSMUSG00000069670.
CleanExiMM_NKAIN2.
ExpressionAtlasiQ4PNJ2. baseline and differential.
GenevisibleiQ4PNJ2. MM.

Interactioni

Subunit structurei

Interacts with ATP1B1.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the NKAIN family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000013699.
HOVERGENiHBG108190.
InParanoidiQ4PNJ2.
OMAiACYVVKL.
OrthoDBiEOG091G0X6F.
PhylomeDBiQ4PNJ2.

Family and domain databases

InterProiView protein in InterPro
IPR008516. Na/K-Atpase_Interacting.
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiView protein in Pfam
PF05640. NKAIN. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4PNJ2-1) [UniParc]FASTAAdd to basket
Also known as: Transcript variant 1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGYCSGRCTL IFICGMQLVC VLERQIFDFL GYQWAPILAN FVHIIIVILG
60 70 80 90 100
LFGTIQYRPR YVTGYAVWLV LWVTWNVFVI CFYLEAGDLS KETDLILTFN
110 120 130 140 150
ISMHRSWWME NGPGCMVTSV TPAPDWAPED HRYITVSGCF LDYQYIEVAH
160 170 180 190 200
SSLQIVLALA GFIYACYVVR CITEEEDSFD FIGGFDSYGY QGPQKTSHLQ

LQPMYMSK
Length:208
Mass (Da):23,895
Last modified:November 13, 2007 - v2
Checksum:i54EFBB877B43B54F
GO
Isoform 2 (identifier: Q4PNJ2-2) [UniParc]FASTAAdd to basket
Also known as: Transcript variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     159-208: LAGFIYACYV...LQLQPMYMSK → VSVDNKPLLL...LMWNVCGHFF

Show »
Length:196
Mass (Da):22,632
Checksum:i7675B8680DA09F1A
GO
Isoform 3 (identifier: Q4PNJ2-3) [UniParc]FASTAAdd to basket
Also known as: Transcript variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     206-208: MSK → IKFPWITTDSKFYISASSDMLNCKRRSK

Show »
Length:233
Mass (Da):26,854
Checksum:iD3971E64F667193A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73V → G in AAY68415 (PubMed:16145689).Curated1
Sequence conflicti73V → G in AAY68416 (PubMed:16145689).Curated1
Sequence conflicti111N → Y in AAX33293 (PubMed:15908570).Curated1
Sequence conflicti152S → P in AAX33293 (PubMed:15908570).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021903159 – 208LAGFI…MYMSK → VSVDNKPLLLVFLELFFLGK HCVQKDCMLMWNVCGHFF in isoform 2. 3 PublicationsAdd BLAST50
Alternative sequenceiVSP_029299206 – 208MSK → IKFPWITTDSKFYISASSDM LNCKRRSK in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ065606 mRNA. Translation: AAY68415.1.
DQ065607 mRNA. Translation: AAY68416.1.
AY940478 mRNA. Translation: AAX33293.1.
EF058049 mRNA. Translation: ABN51167.1.
EF058050 mRNA. Translation: ABN51168.1.
EF058051 mRNA. Translation: ABN51169.1.
BC141063 mRNA. Translation: AAI41064.1.
CCDSiCCDS78805.1. [Q4PNJ2-1]
RefSeqiNP_001013429.2. NM_001013411.2. [Q4PNJ2-1]
NP_001020457.2. NM_001025286.2. [Q4PNJ2-2]
UniGeneiMm.49665.

Genome annotation databases

EnsembliENSMUST00000191234; ENSMUSP00000140463; ENSMUSG00000069670. [Q4PNJ2-1]
ENSMUST00000219125; ENSMUSP00000151959; ENSMUSG00000069670. [Q4PNJ2-2]
GeneIDi432450.
KEGGimmu:432450.
UCSCiuc007etw.2. mouse. [Q4PNJ2-1]
uc007ety.2. mouse. [Q4PNJ2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNKAI2_MOUSE
AccessioniPrimary (citable) accession number: Q4PNJ2
Secondary accession number(s): A6MHP5
, A6MHP6, A6MHP7, B2RUC0, Q4PNJ3, Q5BLW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 13, 2007
Last modified: August 30, 2017
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families