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Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2

Gene

Nkain2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2
Short name:
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2
Alternative name(s):
T-cell lymphoma breakpoint-associated target protein 1
Gene namesi
Name:Nkain2
Synonyms:Tcba1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1923447. Nkain2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 23HelicalSequence analysisAdd BLAST23
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002650891 – 208Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2Add BLAST208

Proteomic databases

PRIDEiQ4PNJ2.

PTM databases

PhosphoSitePlusiQ4PNJ2.

Expressioni

Tissue specificityi

Detected in the brain only and specifically in neurons; expressed in multiple regions such as cerebral cortex, thalamus, cerebellum, olfactory bulb and brainstem, but not in the hippocampus.1 Publication

Gene expression databases

CleanExiMM_NKAIN2.
ExpressionAtlasiQ4PNJ2. baseline and differential.
GenevisibleiQ4PNJ2. MM.

Interactioni

Subunit structurei

Interacts with ATP1B1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ4PNJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NKAIN family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000013699.
HOVERGENiHBG108190.
InParanoidiQ4PNJ2.
OMAiACYVVKL.
OrthoDBiEOG091G0X6F.
PhylomeDBiQ4PNJ2.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4PNJ2-1) [UniParc]FASTAAdd to basket
Also known as: Transcript variant 1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGYCSGRCTL IFICGMQLVC VLERQIFDFL GYQWAPILAN FVHIIIVILG
60 70 80 90 100
LFGTIQYRPR YVTGYAVWLV LWVTWNVFVI CFYLEAGDLS KETDLILTFN
110 120 130 140 150
ISMHRSWWME NGPGCMVTSV TPAPDWAPED HRYITVSGCF LDYQYIEVAH
160 170 180 190 200
SSLQIVLALA GFIYACYVVR CITEEEDSFD FIGGFDSYGY QGPQKTSHLQ

LQPMYMSK
Length:208
Mass (Da):23,895
Last modified:November 13, 2007 - v2
Checksum:i54EFBB877B43B54F
GO
Isoform 2 (identifier: Q4PNJ2-2) [UniParc]FASTAAdd to basket
Also known as: Transcript variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     159-208: LAGFIYACYV...LQLQPMYMSK → VSVDNKPLLL...LMWNVCGHFF

Show »
Length:196
Mass (Da):22,632
Checksum:i7675B8680DA09F1A
GO
Isoform 3 (identifier: Q4PNJ2-3) [UniParc]FASTAAdd to basket
Also known as: Transcript variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     206-208: MSK → IKFPWITTDSKFYISASSDMLNCKRRSK

Show »
Length:233
Mass (Da):26,854
Checksum:iD3971E64F667193A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73V → G in AAY68415 (PubMed:16145689).Curated1
Sequence conflicti73V → G in AAY68416 (PubMed:16145689).Curated1
Sequence conflicti111N → Y in AAX33293 (PubMed:15908570).Curated1
Sequence conflicti152S → P in AAX33293 (PubMed:15908570).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021903159 – 208LAGFI…MYMSK → VSVDNKPLLLVFLELFFLGK HCVQKDCMLMWNVCGHFF in isoform 2. 3 PublicationsAdd BLAST50
Alternative sequenceiVSP_029299206 – 208MSK → IKFPWITTDSKFYISASSDM LNCKRRSK in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ065606 mRNA. Translation: AAY68415.1.
DQ065607 mRNA. Translation: AAY68416.1.
AY940478 mRNA. Translation: AAX33293.1.
EF058049 mRNA. Translation: ABN51167.1.
EF058050 mRNA. Translation: ABN51168.1.
EF058051 mRNA. Translation: ABN51169.1.
BC141063 mRNA. Translation: AAI41064.1.
CCDSiCCDS78805.1. [Q4PNJ2-1]
RefSeqiNP_001013429.2. NM_001013411.2. [Q4PNJ2-1]
NP_001020457.2. NM_001025286.2. [Q4PNJ2-2]
UniGeneiMm.49665.

Genome annotation databases

EnsembliENSMUST00000191234; ENSMUSP00000140463; ENSMUSG00000069670. [Q4PNJ2-1]
GeneIDi432450.
KEGGimmu:432450.
UCSCiuc007etw.2. mouse. [Q4PNJ2-1]
uc007ety.2. mouse. [Q4PNJ2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ065606 mRNA. Translation: AAY68415.1.
DQ065607 mRNA. Translation: AAY68416.1.
AY940478 mRNA. Translation: AAX33293.1.
EF058049 mRNA. Translation: ABN51167.1.
EF058050 mRNA. Translation: ABN51168.1.
EF058051 mRNA. Translation: ABN51169.1.
BC141063 mRNA. Translation: AAI41064.1.
CCDSiCCDS78805.1. [Q4PNJ2-1]
RefSeqiNP_001013429.2. NM_001013411.2. [Q4PNJ2-1]
NP_001020457.2. NM_001025286.2. [Q4PNJ2-2]
UniGeneiMm.49665.

3D structure databases

ProteinModelPortaliQ4PNJ2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ4PNJ2.

Proteomic databases

PRIDEiQ4PNJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000191234; ENSMUSP00000140463; ENSMUSG00000069670. [Q4PNJ2-1]
GeneIDi432450.
KEGGimmu:432450.
UCSCiuc007etw.2. mouse. [Q4PNJ2-1]
uc007ety.2. mouse. [Q4PNJ2-2]

Organism-specific databases

CTDi154215.
MGIiMGI:1923447. Nkain2.

Phylogenomic databases

GeneTreeiENSGT00390000013699.
HOVERGENiHBG108190.
InParanoidiQ4PNJ2.
OMAiACYVVKL.
OrthoDBiEOG091G0X6F.
PhylomeDBiQ4PNJ2.

Miscellaneous databases

ChiTaRSiNkain2. mouse.
PROiQ4PNJ2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_NKAIN2.
ExpressionAtlasiQ4PNJ2. baseline and differential.
GenevisibleiQ4PNJ2. MM.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNKAI2_MOUSE
AccessioniPrimary (citable) accession number: Q4PNJ2
Secondary accession number(s): A6MHP5
, A6MHP6, A6MHP7, B2RUC0, Q4PNJ3, Q5BLW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.