Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitogen-activated protein kinase HOG1

Gene

HOG1

Organism
Fusarium culmorum
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei4ATPPROSITE-ProRule annotation1
Active sitei96Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase HOG1 (EC:2.7.11.24)
Short name:
MAP kinase HOG1
Gene namesi
Name:HOG1
OrganismiFusarium culmorum
Taxonomic identifieri5516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000289689‹1 – ›207Mitogen-activated protein kinase HOG1Add BLAST›207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphothreonineBy similarity1
Modified residuei128PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-126 and Tyr-128, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4PNJ1

Structurei

3D structure databases

ProteinModelPortaliQ4PNJ1
SMRiQ4PNJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – ›207Protein kinasePROSITE-ProRule annotationAdd BLAST›207

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 128TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR038783 MAPK_Sty1/Hog1
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24055:SF247 PTHR24055:SF247, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Fragment.

Q4PNJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VAVKKIMKPF STPVLAKRTY RELKLLKHLK HENVISLSDI FISPLEDIYF
60 70 80 90 100
VTELLGTDLH RLLTSRPLEK QFIQYFLYQI MRGLKYVHSA GVVHRDLKPS
110 120 130 140 150
NILVNENCDL KICDFGLARI QDPQMTGYVS TRYYRAPEIM LTWQKYDVEV
160 170 180 190 200
DIWSAGCIFA EMLEGKPLFP GKDHVNQFSI ITELLGTPPD DVINTIASEN

TLRFVKS
Length:207
Mass (Da):23,878
Last modified:July 19, 2005 - v1
Checksum:i5604D60D7FC09623
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2071

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ065608 Genomic DNA Translation: AAY63969.1

Similar proteinsi

Entry informationi

Entry nameiHOG1_FUSCU
AccessioniPrimary (citable) accession number: Q4PNJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health