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Protein
Submitted name:

NACHT

Gene

Nlrp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
NACHTImported
Submitted name:
Protein Nlrp2Imported
Gene namesi
Name:Nlrp2Imported
Synonyms:Nalp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3041206. Nlrp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045077.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini180 – 387208NACHTInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains NACHT domain.SAAS annotation
Contains pyrin domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IM14. Eukaryota.
ENOG410ZI5C. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000294064.
HOVERGENiHBG103856.
KOiK19409.
OMAiCESISCT.
OrthoDBiEOG7P5T07.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 3 hits.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4PLS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHFDPLGFN LKDVLRKLDK TELNNFKRTL RSCSLPDTMK QINKLTMDLA
60 70 80 90 100
NGAQLAEILT DHCPSAWIKR VTVQILEEIN RVDLAELVVK QIEEAVLKVP
110 120 130 140 150
EEKVSSKPRE PSGTLTFPWN FVQGAKRPED KQKEEWKTRY TAKWKQNFWP
160 170 180 190 200
KCNKEIYVVT ESYKTLLALC NPKIETPFAH AIVLHGPPGS GKTTMAKQLM
210 220 230 240 250
LEWSESKQAQ IFSCAFYISC REVNNTKPCT FAHLLSMDNP SWRDCVIRDL
260 270 280 290 300
ILGKEFLFVV DGFDELTFPA GALIRDLCGD WNTVKPVEVL LGSLLKRKMA
310 320 330 340 350
PHATLLVTTR TQSLHQIFVM MDQPLLVETL GFLEQEKQEY FQKYFEDEEG
360 370 380 390 400
EEEDKGEGKA LRALKEVRCN ADLYQMASLP TACGIFCLCL ELRMKKGEDL
410 420 430 440 450
SLTCQTYTSM FLNFLCEVFS SETCEDHLNE EFQILFKKIC ILAANSLLEQ
460 470 480 490 500
VPILCEEDFL TLKLNLNNLH PMVCRHILFK DSSSTHCLSF ICLGIQQLLA
510 520 530 540 550
AIIFVQELGQ ESKGVSKYSI QNMLSREARL KNPDLSGLLP FVFGLLNETR
560 570 580 590 600
IQELKTTFGC QISTEVKRKF LECESGENKP LLLLMNMQEI LSCLYESQEE
610 620 630 640 650
GFVKEAMVLF EDISLHLKTS TDLIHASFCL KNSQNLQTMS LKVEKAVFPE
660 670 680 690 700
NVAALESTAK HQRSPDEQRM LTFWTDFCDT FNSNKKLVFL DIHESFLNSS
710 720 730 740 750
ALEILCEKLP SASCCLQKVV LKNISPDDAY EKLCLIFNGY KTISHLILQG
760 770 780 790 800
GNLDSMHHSL CEVLKNPACN LKFLSLGSCS TAAQKWDDFF PVLKVNQSLI
810 820 830 840 850
FLDLTDNSLL DKSAKLLCNI WKEPKCILQR VSLENCQLTE ACCKDLSSVL
860 870 880 890 900
MVSRTLTHLS LANNKLGDNG VKNLCESISC TECNLQTLVL WSCNITNAGC
910 920 930 940 950
HYLSKMLKQT LSLKHLDLGL NRIGTKGAKF LCEALKNPKS KLKSLWLCGC
960 970 980 990 1000
SITPLNCQDF SETLRSNKSL NTLDLSQNVL GTDAIKTFCE ALKLQICPLQ
1010 1020 1030 1040
MLRLKFDEAK PSIQNLIQEM KVSHPQLRIS SDQVDLKNPP LPHFIF
Length:1,046
Mass (Da):118,641
Last modified:July 19, 2005 - v1
Checksum:iC504DCA8693D02C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155171 Genomic DNA. No translation available.
DQ066881 mRNA. Translation: AAY68479.1.
RefSeqiNP_808358.2. NM_177690.3.
UniGeneiMm.246598.

Genome annotation databases

EnsembliENSMUST00000045022; ENSMUSP00000045077; ENSMUSG00000035177.
GeneIDi232827.
KEGGimmu:232827.
UCSCiuc009fae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155171 Genomic DNA. No translation available.
DQ066881 mRNA. Translation: AAY68479.1.
RefSeqiNP_808358.2. NM_177690.3.
UniGeneiMm.246598.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045077.

Protocols and materials databases

DNASUi232827.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045022; ENSMUSP00000045077; ENSMUSG00000035177.
GeneIDi232827.
KEGGimmu:232827.
UCSCiuc009fae.1. mouse.

Organism-specific databases

CTDi55655.
MGIiMGI:3041206. Nlrp2.

Phylogenomic databases

eggNOGiENOG410IM14. Eukaryota.
ENOG410ZI5C. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000294064.
HOVERGENiHBG103856.
KOiK19409.
OMAiCESISCT.
OrthoDBiEOG7P5T07.

Miscellaneous databases

NextBioi381262.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 3 hits.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Zhang X., Ding X., Zhu Z., Ren J., Liu K., Ma R.Z.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ4PLS0_MOUSE
AccessioniPrimary (citable) accession number: Q4PLS0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.