Q4PKS0 (HOG1_GIBIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitogen-activated protein kinase HOG1
Short name=MAP kinase HOG1
EC=2.7.11.24

Gene names

Name:

HOG1

Organism

Gibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum)

Taxonomic identifier

948311 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella › Fusarium fujikuroi complex

Protein attributes

Sequence length	200 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Enzyme regulation	Activated by tyrosine and threonine phosphorylation By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Domain	The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Post-translational modification	Dually phosphorylated on Thr-126 and Tyr-128, which activates the enzyme By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Activator Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›200	›200	Mitogen-activated protein kinase HOG1		PRO_0000289690
Regions
	Domain	‹1 – ›200	›200	Protein kinase
	Motif	126 – 128	3	TXY
Sites
	Active site	96	1	Proton acceptor By similarity
	Binding site	4	1	ATP By similarity
Amino acid modifications
	Modified residue	126	1	Phosphothreonine By similarity
	Modified residue	128	1	Phosphotyrosine By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	200	1

Sequences

	Sequence		Length	Mass (Da)
	Q4PKS0 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 733A6852DCA64CAF	FASTA	200	23,046
	10 20 30 40 50 60 VAVKKIMKPF STPVLAKRTY RELKLLKHLK HENVISLSDI FISPLEDIYF VTELLGTDLH 70 80 90 100 110 120 RLLTSRPLEK QFIQYFLYQI MRGLKYVHSA GVVHRDLKPS NILVNENCDL KICDFGLARI 130 140 150 160 170 180 QDPQMTGYVS TRYYRAPEIM LTWQKYDVEV DIWSAGCIFA EMLEGKPLFP GKDHVNQFSI 190 200 ITELLGTPPD DVINTIASEN

References

[1]	"Identification of new molecular hallmarks for YSAPK MAPKs: application for cloning strategies in different fungal filamentous species." Adam A.L., Kohut G., Laday M. Acta Phytopathol. Entomol. Hung. 40:233-249(2005) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ITEM 2287.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ071424 Genomic DNA. Translation: AAY82586.1.
3D structure databases
HSSP	HSSP built from PDB template 2BAJ based on UniProtKB Q16539.
ProteinModelPortal	Q4PKS0.
SMR	Q4PKS0. Positions 1-198.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR003527. MAP_kinase_CS. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS01351. MAPK. 1 hit. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HOG1_GIBIN

Accession

Primary (citable) accession number: Q4PKS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	July 19, 2005
Last modified:	March 6, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program