SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4PKS0

- HOG1_GIBIN

UniProt

Q4PKS0 - HOG1_GIBIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mitogen-activated protein kinase HOG1
Gene
HOG1
Organism
Gibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4 – 41ATP By similarity
Active sitei96 – 961Proton acceptor By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase HOG1 (EC:2.7.11.24)
Short name:
MAP kinase HOG1
Gene namesi
Name:HOG1
OrganismiGibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum)
Taxonomic identifieri948311 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium fujikuroi species complex

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›200›200Mitogen-activated protein kinase HOG1
PRO_0000289690Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei126 – 1261Phosphothreonine By similarity
Modified residuei128 – 1281Phosphotyrosine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-126 and Tyr-128, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ4PKS0.
SMRiQ4PKS0. Positions 1-198.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – ›200›200Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 1283TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4PKS0-1 [UniParc]FASTAAdd to Basket

« Hide

VAVKKIMKPF STPVLAKRTY RELKLLKHLK HENVISLSDI FISPLEDIYF    50
VTELLGTDLH RLLTSRPLEK QFIQYFLYQI MRGLKYVHSA GVVHRDLKPS 100
NILVNENCDL KICDFGLARI QDPQMTGYVS TRYYRAPEIM LTWQKYDVEV 150
DIWSAGCIFA EMLEGKPLFP GKDHVNQFSI ITELLGTPPD DVINTIASEN 200
Length:200
Mass (Da):23,046
Last modified:July 19, 2005 - v1
Checksum:i733A6852DCA64CAF
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei200 – 2001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ071424 Genomic DNA. Translation: AAY82586.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ071424 Genomic DNA. Translation: AAY82586.1 .

3D structure databases

ProteinModelPortali Q4PKS0.
SMRi Q4PKS0. Positions 1-198.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of new molecular hallmarks for YSAPK MAPKs: application for cloning strategies in different fungal filamentous species."
    Adam A.L., Kohut G., Laday M.
    Acta Phytopathol. Entomol. Hung. 40:233-249(2005)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ITEM 2287.

Entry informationi

Entry nameiHOG1_GIBIN
AccessioniPrimary (citable) accession number: Q4PKS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 19, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi