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Q4PKS0 (HOG1_GIBIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase HOG1

Short name=MAP kinase HOG1
EC=2.7.11.24
Gene names
Name:HOG1
OrganismGibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum)
Taxonomic identifier948311 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaemitosporic NectriaceaeFusariumFusarium fujikuroi species complex

Protein attributes

Sequence length200 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-126 and Tyr-128, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›200›200Mitogen-activated protein kinase HOG1
PRO_0000289690

Regions

Domain‹1 – ›200›200Protein kinase
Motif126 – 1283TXY

Sites

Active site961Proton acceptor By similarity
Binding site41ATP By similarity

Amino acid modifications

Modified residue1261Phosphothreonine By similarity
Modified residue1281Phosphotyrosine By similarity

Experimental info

Non-terminal residue11
Non-terminal residue2001

Sequences

Sequence LengthMass (Da)Tools
Q4PKS0 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 733A6852DCA64CAF

FASTA20023,046
        10         20         30         40         50         60 
VAVKKIMKPF STPVLAKRTY RELKLLKHLK HENVISLSDI FISPLEDIYF VTELLGTDLH 

        70         80         90        100        110        120 
RLLTSRPLEK QFIQYFLYQI MRGLKYVHSA GVVHRDLKPS NILVNENCDL KICDFGLARI 

       130        140        150        160        170        180 
QDPQMTGYVS TRYYRAPEIM LTWQKYDVEV DIWSAGCIFA EMLEGKPLFP GKDHVNQFSI 

       190        200 
ITELLGTPPD DVINTIASEN 

« Hide

References

[1]"Identification of new molecular hallmarks for YSAPK MAPKs: application for cloning strategies in different fungal filamentous species."
Adam A.L., Kohut G., Laday M.
Acta Phytopathol. Entomol. Hung. 40:233-249(2005)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ITEM 2287.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ071424 Genomic DNA. Translation: AAY82586.1.

3D structure databases

ProteinModelPortalQ4PKS0.
SMRQ4PKS0. Positions 1-198.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOG1_GIBIN
AccessionPrimary (citable) accession number: Q4PKS0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families