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Q4PJW2

- NCOA1_PIG

UniProt

Q4PJW2 - NCOA1_PIG

Protein

Nuclear receptor coactivator 1

Gene

NCOA1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. ligand-dependent nuclear receptor transcription coactivator activity Source: InterPro
    3. signal transducer activity Source: InterPro
    4. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Receptor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor coactivator 1 (EC:2.3.1.48)
    Short name:
    NCoA-1
    Alternative name(s):
    Steroid receptor coactivator 1
    Short name:
    SRC-1
    Gene namesi
    Name:NCOA1
    Synonyms:SRC1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 14401439Nuclear receptor coactivator 1PRO_0000300687Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei372 – 3721PhosphoserineBy similarity
    Modified residuei395 – 3951PhosphoserineBy similarity
    Modified residuei517 – 5171PhosphoserineBy similarity
    Modified residuei569 – 5691PhosphoserineBy similarity
    Modified residuei698 – 6981PhosphoserineBy similarity
    Cross-linki732 – 732Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Cross-linki774 – 774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Modified residuei1033 – 10331PhosphoserineBy similarity
    Modified residuei1179 – 11791PhosphothreonineBy similarity
    Modified residuei1185 – 11851PhosphoserineBy similarity

    Post-translational modificationi

    Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein By similarity.By similarity
    Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites By similarity.By similarity

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Interactioni

    Subunit structurei

    Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with COPS5, NR3C1, PCAF and TTLL5/STAMP. Interacts with the histone acetyltransferases EP300 and CREBBP, and the methyltransferase CARM1. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6. Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts in a ligand-dependent fashion with RXRA By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ4PJW2.
    SMRiQ4PJW2. Positions 259-367, 920-974.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 8058bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini109 – 18072PASPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni361 – 567207Interaction with STAT3By similarityAdd
    BLAST
    Regioni781 – 988208Interaction with CREBBPBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 505LXXLL motif 1By similarity
    Motifi112 – 1165LXXLL motif 2By similarity
    Motifi633 – 6375LXXLL motif 3By similarity
    Motifi690 – 6945LXXLL motif 4By similarity
    Motifi749 – 7535LXXLL motif 5By similarity
    Motifi913 – 9175LXXLL motif 6By similarity
    Motifi1434 – 14385LXXLL motif 7By similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi389 – 682294Ser-richAdd
    BLAST
    Compositional biasi1053 – 113886Gln-richAdd
    BLAST

    Domaini

    The C-terminal (1107-1447) part mediates the histone acetyltransferase (HAT) activity.By similarity

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG315556.
    HOVERGENiHBG052583.
    KOiK09101.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    4.10.630.10. 2 hits.
    InterProiIPR011598. bHLH_dom.
    IPR010011. DUF1518.
    IPR028819. NCOA1.
    IPR009110. Nuc_rcpt_coact.
    IPR014920. Nuc_rcpt_coact_Ncoa-typ.
    IPR017426. Nuclear_rcpt_coactivator.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR014935. SRC-1.
    IPR008955. Src1_rcpt_coact.
    [Graphical view]
    PANTHERiPTHR10684. PTHR10684. 1 hit.
    PTHR10684:SF1. PTHR10684:SF1. 1 hit.
    PfamiPF07469. DUF1518. 2 hits.
    PF08815. Nuc_rec_co-act. 1 hit.
    PF00989. PAS. 1 hit.
    PF08832. SRC-1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
    SMARTiSM00353. HLH. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    SSF69125. SSF69125. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4PJW2-1 [UniParc]FASTAAdd to Basket

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    MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL     50
    SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDEVQKSDIS 100
    SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE 150
    LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG VPWPQEATRR NSHTFNCRML 200
    IHPPDEPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ SCLICIARRL 250
    PRPPAIMGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWEE FMRKCIYAFF 300
    QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ 350
    SPDMQPFIMG IHIIDREHSG LSPQDDTNSG MSIPRVNPPV NPSISPAHGV 400
    ARSSSLPPSN SNMVSTRVNR QQSSDLHSSS HSNSSNSQGS FGCSPGNQIV 450
    AGVALNQGQA SSQSTNPPLN LNNSPMEGTG ISLAQFMSPR RQVSSGLATR 500
    PRMPNNSFPP NIPTLNSPVS MTSTACNNSN RSYSNIPVTS LQSMNEGPNN 550
    SVGFSAGSPV LRQMSSQNSP SRLNIQPAKA ESKDNKETAS ILNEMIQSDN 600
    SSNDGKPLDS GLLHNNDRLS DGDNKYSQTS HKLVQLLTTT AEQQLRHADI 650
    DTSCKEVLSC TGTSSSASAN SSSGSCPSSH SSLTERHKIL HRLLQEGSPS 700
    DITTLSVEPD KKDSASTSVS VTGQVPGNSG IKLELDASKK KESKDHQLLR 750
    YLLDKDEKDL RSTPNLSLDD VKVKVEKKEQ MDPCNTNPTP MTKPPPEEIK 800
    LESQSQFTAD LDQFDQLLPT LEKAAQLPGL CETERMDGAV TSVTIKSEIL 850
    PATLQSTTAR PTSRLNRLPE LELEAIDNQF GQPGTGDQIP WANNTVTAVN 900
    QNKPEDQCIS SQLDELLCPP TTVEGRNDEK ALLEQLVSFL SGKDETELAE 950
    LDRALGIDKL VQGGGLDVLS ERFPPQQATP PLMMEERPNL YSQPYSSPSP 1000
    TANLSGPFQG MVRQKPSLGT MPVQVTPPRG AFSPGMGMQP RQTLNRPPAA 1050
    PNQLRLQLQQ RLQGQQQLIH QNRQAILNQF AANAPVGINM RSGMQQQITP 1100
    QPPLNAQMLA QRQRELYSQQ HRRRQLIQQQ RAMLMRQQSF GNNLPPSSGL 1150
    PVPMGNPRLP QGAPQQFPYP PNYGTNPGTP PASTSPFSQL AENPEATLGN 1200
    RNSMVNRGMT GNMGGQFGTG INPQMQQNVF QYPGSGMVPQ GEANFAPSLS 1250
    PGSSMVPMPI PPPQSSLLQQ TPPASGYQSP DMKAWQQGAM GNNNVFSQAV 1300
    QNQPTPAQPG VYNNMSITVS MAGGNTNVQN MNPMMGQMQM SSLQMPGMNT 1350
    VCPEQINDPA LRHTGLYCNQ LSSTDLLKTE ADGTQVQQVQ VFADVQCTVN 1400
    LVGGDPYLNQ PGPLGTQKPT AGPQTPQAQQ KSLLQQLLTE 1440
    Length:1,440
    Mass (Da):156,925
    Last modified:July 19, 2005 - v1
    Checksum:i79B850ED7958AF50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ078269 mRNA. Translation: AAY82453.1.
    RefSeqiNP_001020399.1. NM_001025228.1.
    UniGeneiSsc.24299.

    Genome annotation databases

    GeneIDi574068.
    KEGGissc:574068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ078269 mRNA. Translation: AAY82453.1 .
    RefSeqi NP_001020399.1. NM_001025228.1.
    UniGenei Ssc.24299.

    3D structure databases

    ProteinModelPortali Q4PJW2.
    SMRi Q4PJW2. Positions 259-367, 920-974.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 574068.
    KEGGi ssc:574068.

    Organism-specific databases

    CTDi 8648.

    Phylogenomic databases

    eggNOGi NOG315556.
    HOVERGENi HBG052583.
    KOi K09101.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    4.10.630.10. 2 hits.
    InterProi IPR011598. bHLH_dom.
    IPR010011. DUF1518.
    IPR028819. NCOA1.
    IPR009110. Nuc_rcpt_coact.
    IPR014920. Nuc_rcpt_coact_Ncoa-typ.
    IPR017426. Nuclear_rcpt_coactivator.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR014935. SRC-1.
    IPR008955. Src1_rcpt_coact.
    [Graphical view ]
    PANTHERi PTHR10684. PTHR10684. 1 hit.
    PTHR10684:SF1. PTHR10684:SF1. 1 hit.
    Pfami PF07469. DUF1518. 2 hits.
    PF08815. Nuc_rec_co-act. 1 hit.
    PF00989. PAS. 1 hit.
    PF08832. SRC-1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038181. Nuclear_receptor_coactivator. 1 hit.
    SMARTi SM00353. HLH. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    SSF69125. SSF69125. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of nuclear receptor coactivator-1 gene in pig."
      Yu D., Mneg H., Bai C., Zhao W., Wang Q.S., Pan Y.
      DNA Seq. 17:79-82(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiNCOA1_PIG
    AccessioniPrimary (citable) accession number: Q4PJW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3