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Q4PJW2

- NCOA1_PIG

UniProt

Q4PJW2 - NCOA1_PIG

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Protein

Nuclear receptor coactivator 1

Gene

NCOA1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: InterPro
  3. signal transducer activity Source: InterPro
  4. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Receptor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 1 (EC:2.3.1.48)
Short name:
NCoA-1
Alternative name(s):
Steroid receptor coactivator 1
Short name:
SRC-1
Gene namesi
Name:NCOA1
Synonyms:SRC1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 14401439Nuclear receptor coactivator 1PRO_0000300687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei372 – 3721PhosphoserineBy similarity
Modified residuei395 – 3951PhosphoserineBy similarity
Modified residuei517 – 5171PhosphoserineBy similarity
Modified residuei569 – 5691PhosphoserineBy similarity
Modified residuei698 – 6981PhosphoserineBy similarity
Cross-linki732 – 732Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki774 – 774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei1033 – 10331PhosphoserineBy similarity
Modified residuei1179 – 11791PhosphothreonineBy similarity
Modified residuei1185 – 11851PhosphoserineBy similarity

Post-translational modificationi

Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein (By similarity).By similarity
Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with COPS5, NR3C1, PCAF and TTLL5/STAMP. Interacts with the histone acetyltransferases EP300 and CREBBP, and the methyltransferase CARM1. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6. Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts in a ligand-dependent fashion with RXRA (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4PJW2.
SMRiQ4PJW2. Positions 259-367, 920-974.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 8058bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini109 – 18072PASPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni361 – 567207Interaction with STAT3By similarityAdd
BLAST
Regioni781 – 988208Interaction with CREBBPBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 505LXXLL motif 1By similarity
Motifi112 – 1165LXXLL motif 2By similarity
Motifi633 – 6375LXXLL motif 3By similarity
Motifi690 – 6945LXXLL motif 4By similarity
Motifi749 – 7535LXXLL motif 5By similarity
Motifi913 – 9175LXXLL motif 6By similarity
Motifi1434 – 14385LXXLL motif 7By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi389 – 682294Ser-richAdd
BLAST
Compositional biasi1053 – 113886Gln-richAdd
BLAST

Domaini

The C-terminal (1107-1447) part mediates the histone acetyltransferase (HAT) activity.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG315556.
HOVERGENiHBG052583.
InParanoidiQ4PJW2.
KOiK09101.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR028819. NCOA1.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF1. PTHR10684:SF1. 1 hit.
PfamiPF07469. DUF1518. 2 hits.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4PJW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL
60 70 80 90 100
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDEVQKSDIS
110 120 130 140 150
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE
160 170 180 190 200
LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG VPWPQEATRR NSHTFNCRML
210 220 230 240 250
IHPPDEPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ SCLICIARRL
260 270 280 290 300
PRPPAIMGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWEE FMRKCIYAFF
310 320 330 340 350
QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ
360 370 380 390 400
SPDMQPFIMG IHIIDREHSG LSPQDDTNSG MSIPRVNPPV NPSISPAHGV
410 420 430 440 450
ARSSSLPPSN SNMVSTRVNR QQSSDLHSSS HSNSSNSQGS FGCSPGNQIV
460 470 480 490 500
AGVALNQGQA SSQSTNPPLN LNNSPMEGTG ISLAQFMSPR RQVSSGLATR
510 520 530 540 550
PRMPNNSFPP NIPTLNSPVS MTSTACNNSN RSYSNIPVTS LQSMNEGPNN
560 570 580 590 600
SVGFSAGSPV LRQMSSQNSP SRLNIQPAKA ESKDNKETAS ILNEMIQSDN
610 620 630 640 650
SSNDGKPLDS GLLHNNDRLS DGDNKYSQTS HKLVQLLTTT AEQQLRHADI
660 670 680 690 700
DTSCKEVLSC TGTSSSASAN SSSGSCPSSH SSLTERHKIL HRLLQEGSPS
710 720 730 740 750
DITTLSVEPD KKDSASTSVS VTGQVPGNSG IKLELDASKK KESKDHQLLR
760 770 780 790 800
YLLDKDEKDL RSTPNLSLDD VKVKVEKKEQ MDPCNTNPTP MTKPPPEEIK
810 820 830 840 850
LESQSQFTAD LDQFDQLLPT LEKAAQLPGL CETERMDGAV TSVTIKSEIL
860 870 880 890 900
PATLQSTTAR PTSRLNRLPE LELEAIDNQF GQPGTGDQIP WANNTVTAVN
910 920 930 940 950
QNKPEDQCIS SQLDELLCPP TTVEGRNDEK ALLEQLVSFL SGKDETELAE
960 970 980 990 1000
LDRALGIDKL VQGGGLDVLS ERFPPQQATP PLMMEERPNL YSQPYSSPSP
1010 1020 1030 1040 1050
TANLSGPFQG MVRQKPSLGT MPVQVTPPRG AFSPGMGMQP RQTLNRPPAA
1060 1070 1080 1090 1100
PNQLRLQLQQ RLQGQQQLIH QNRQAILNQF AANAPVGINM RSGMQQQITP
1110 1120 1130 1140 1150
QPPLNAQMLA QRQRELYSQQ HRRRQLIQQQ RAMLMRQQSF GNNLPPSSGL
1160 1170 1180 1190 1200
PVPMGNPRLP QGAPQQFPYP PNYGTNPGTP PASTSPFSQL AENPEATLGN
1210 1220 1230 1240 1250
RNSMVNRGMT GNMGGQFGTG INPQMQQNVF QYPGSGMVPQ GEANFAPSLS
1260 1270 1280 1290 1300
PGSSMVPMPI PPPQSSLLQQ TPPASGYQSP DMKAWQQGAM GNNNVFSQAV
1310 1320 1330 1340 1350
QNQPTPAQPG VYNNMSITVS MAGGNTNVQN MNPMMGQMQM SSLQMPGMNT
1360 1370 1380 1390 1400
VCPEQINDPA LRHTGLYCNQ LSSTDLLKTE ADGTQVQQVQ VFADVQCTVN
1410 1420 1430 1440
LVGGDPYLNQ PGPLGTQKPT AGPQTPQAQQ KSLLQQLLTE
Length:1,440
Mass (Da):156,925
Last modified:July 19, 2005 - v1
Checksum:i79B850ED7958AF50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ078269 mRNA. Translation: AAY82453.1.
RefSeqiNP_001020399.1. NM_001025228.1.
UniGeneiSsc.24299.

Genome annotation databases

GeneIDi574068.
KEGGissc:574068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ078269 mRNA. Translation: AAY82453.1 .
RefSeqi NP_001020399.1. NM_001025228.1.
UniGenei Ssc.24299.

3D structure databases

ProteinModelPortali Q4PJW2.
SMRi Q4PJW2. Positions 259-367, 920-974.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 574068.
KEGGi ssc:574068.

Organism-specific databases

CTDi 8648.

Phylogenomic databases

eggNOGi NOG315556.
HOVERGENi HBG052583.
InParanoidi Q4PJW2.
KOi K09101.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProi IPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR028819. NCOA1.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view ]
PANTHERi PTHR10684. PTHR10684. 1 hit.
PTHR10684:SF1. PTHR10684:SF1. 1 hit.
Pfami PF07469. DUF1518. 2 hits.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view ]
PIRSFi PIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTi SM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of nuclear receptor coactivator-1 gene in pig."
    Yu D., Mneg H., Bai C., Zhao W., Wang Q.S., Pan Y.
    DNA Seq. 17:79-82(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNCOA1_PIG
AccessioniPrimary (citable) accession number: Q4PJW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3