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Q4PJW2

- NCOA1_PIG

UniProt

Q4PJW2 - NCOA1_PIG

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Protein
Nuclear receptor coactivator 1
Gene
NCOA1, SRC1
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: InterPro
  3. signal transducer activity Source: InterPro
  4. transcription coactivator activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Receptor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 1 (EC:2.3.1.48)
Short name:
NCoA-1
Alternative name(s):
Steroid receptor coactivator 1
Short name:
SRC-1
Gene namesi
Name:NCOA1
Synonyms:SRC1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 14401439Nuclear receptor coactivator 1
PRO_0000300687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei22 – 221Phosphoserine By similarity
Modified residuei372 – 3721Phosphoserine By similarity
Modified residuei395 – 3951Phosphoserine By similarity
Modified residuei517 – 5171Phosphoserine By similarity
Modified residuei569 – 5691Phosphoserine By similarity
Modified residuei698 – 6981Phosphoserine By similarity
Cross-linki732 – 732Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Cross-linki774 – 774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei1033 – 10331Phosphoserine By similarity
Modified residuei1179 – 11791Phosphothreonine By similarity
Modified residuei1185 – 11851Phosphoserine By similarity

Post-translational modificationi

Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein By similarity.
Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites By similarity.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with COPS5, NR3C1, PCAF and TTLL5/STAMP. Interacts with the histone acetyltransferases EP300 and CREBBP, and the methyltransferase CARM1. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6. Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts in a ligand-dependent fashion with RXRA By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ4PJW2.
SMRiQ4PJW2. Positions 259-367, 920-974.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 8058bHLH
Add
BLAST
Domaini109 – 18072PAS
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni361 – 567207Interaction with STAT3 By similarity
Add
BLAST
Regioni781 – 988208Interaction with CREBBP By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 505LXXLL motif 1 By similarity
Motifi112 – 1165LXXLL motif 2 By similarity
Motifi633 – 6375LXXLL motif 3 By similarity
Motifi690 – 6945LXXLL motif 4 By similarity
Motifi749 – 7535LXXLL motif 5 By similarity
Motifi913 – 9175LXXLL motif 6 By similarity
Motifi1434 – 14385LXXLL motif 7 By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi389 – 682294Ser-rich
Add
BLAST
Compositional biasi1053 – 113886Gln-rich
Add
BLAST

Domaini

The C-terminal (1107-1447) part mediates the histone acetyltransferase (HAT) activity By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG315556.
HOVERGENiHBG052583.
KOiK09101.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR028819. NCOA1.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF1. PTHR10684:SF1. 1 hit.
PfamiPF07469. DUF1518. 2 hits.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4PJW2-1 [UniParc]FASTAAdd to Basket

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MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL     50
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDEVQKSDIS 100
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE 150
LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG VPWPQEATRR NSHTFNCRML 200
IHPPDEPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ SCLICIARRL 250
PRPPAIMGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWEE FMRKCIYAFF 300
QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ 350
SPDMQPFIMG IHIIDREHSG LSPQDDTNSG MSIPRVNPPV NPSISPAHGV 400
ARSSSLPPSN SNMVSTRVNR QQSSDLHSSS HSNSSNSQGS FGCSPGNQIV 450
AGVALNQGQA SSQSTNPPLN LNNSPMEGTG ISLAQFMSPR RQVSSGLATR 500
PRMPNNSFPP NIPTLNSPVS MTSTACNNSN RSYSNIPVTS LQSMNEGPNN 550
SVGFSAGSPV LRQMSSQNSP SRLNIQPAKA ESKDNKETAS ILNEMIQSDN 600
SSNDGKPLDS GLLHNNDRLS DGDNKYSQTS HKLVQLLTTT AEQQLRHADI 650
DTSCKEVLSC TGTSSSASAN SSSGSCPSSH SSLTERHKIL HRLLQEGSPS 700
DITTLSVEPD KKDSASTSVS VTGQVPGNSG IKLELDASKK KESKDHQLLR 750
YLLDKDEKDL RSTPNLSLDD VKVKVEKKEQ MDPCNTNPTP MTKPPPEEIK 800
LESQSQFTAD LDQFDQLLPT LEKAAQLPGL CETERMDGAV TSVTIKSEIL 850
PATLQSTTAR PTSRLNRLPE LELEAIDNQF GQPGTGDQIP WANNTVTAVN 900
QNKPEDQCIS SQLDELLCPP TTVEGRNDEK ALLEQLVSFL SGKDETELAE 950
LDRALGIDKL VQGGGLDVLS ERFPPQQATP PLMMEERPNL YSQPYSSPSP 1000
TANLSGPFQG MVRQKPSLGT MPVQVTPPRG AFSPGMGMQP RQTLNRPPAA 1050
PNQLRLQLQQ RLQGQQQLIH QNRQAILNQF AANAPVGINM RSGMQQQITP 1100
QPPLNAQMLA QRQRELYSQQ HRRRQLIQQQ RAMLMRQQSF GNNLPPSSGL 1150
PVPMGNPRLP QGAPQQFPYP PNYGTNPGTP PASTSPFSQL AENPEATLGN 1200
RNSMVNRGMT GNMGGQFGTG INPQMQQNVF QYPGSGMVPQ GEANFAPSLS 1250
PGSSMVPMPI PPPQSSLLQQ TPPASGYQSP DMKAWQQGAM GNNNVFSQAV 1300
QNQPTPAQPG VYNNMSITVS MAGGNTNVQN MNPMMGQMQM SSLQMPGMNT 1350
VCPEQINDPA LRHTGLYCNQ LSSTDLLKTE ADGTQVQQVQ VFADVQCTVN 1400
LVGGDPYLNQ PGPLGTQKPT AGPQTPQAQQ KSLLQQLLTE 1440
Length:1,440
Mass (Da):156,925
Last modified:July 19, 2005 - v1
Checksum:i79B850ED7958AF50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ078269 mRNA. Translation: AAY82453.1.
RefSeqiNP_001020399.1. NM_001025228.1.
UniGeneiSsc.24299.

Genome annotation databases

GeneIDi574068.
KEGGissc:574068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ078269 mRNA. Translation: AAY82453.1 .
RefSeqi NP_001020399.1. NM_001025228.1.
UniGenei Ssc.24299.

3D structure databases

ProteinModelPortali Q4PJW2.
SMRi Q4PJW2. Positions 259-367, 920-974.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 574068.
KEGGi ssc:574068.

Organism-specific databases

CTDi 8648.

Phylogenomic databases

eggNOGi NOG315556.
HOVERGENi HBG052583.
KOi K09101.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProi IPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR028819. NCOA1.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view ]
PANTHERi PTHR10684. PTHR10684. 1 hit.
PTHR10684:SF1. PTHR10684:SF1. 1 hit.
Pfami PF07469. DUF1518. 2 hits.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view ]
PIRSFi PIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTi SM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of nuclear receptor coactivator-1 gene in pig."
    Yu D., Mneg H., Bai C., Zhao W., Wang Q.S., Pan Y.
    DNA Seq. 17:79-82(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNCOA1_PIG
AccessioniPrimary (citable) accession number: Q4PJW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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